Molecules 2013, 18(2), 2018-2028; doi:10.3390/molecules18022018
Article

The Degradation Mechanism of Toxic Atractyloside in Herbal Medicines by Decoction

Received: 12 December 2012; in revised form: 31 January 2013 / Accepted: 1 February 2013 / Published: 5 February 2013
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Atractyloside (ATR) is found in many Asteraceae plants that are commonly used as medicinal herbs in China and other eastern Asian countries. ATR binds specifically to the adenine nucleotide translocator in the inner mitochondrial membrane and competitively inhibits ADP and ATP transport. The toxicity of ATR in medical herbs can be reduced by hydrothermal processing, but the mechanisms of ATR degradation are not well understood. In this study, GC-MS coupled with SPE and TMS derivatisation was used to detect ATR levels in traditional Chinese medicinal herbs. Our results suggest that ATR molecules were disrupted by decomposition, hydrolysis and saponification after heating with water (decoction) for a long period of time. Hydrothermal processing could decompose the endogenous toxic compounds and also facilitate the detoxification of raw materials used in the Chinese medicine industry.
Keywords: atractyloside; decoction; herbal medicines
PDF Full-text Download PDF Full-Text [1465 KB, uploaded 18 June 2014 20:01 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Chen, L.-Y.; Hu, A.; Chang, C.-J. The Degradation Mechanism of Toxic Atractyloside in Herbal Medicines by Decoction. Molecules 2013, 18, 2018-2028.

AMA Style

Chen L-Y, Hu A, Chang C-J. The Degradation Mechanism of Toxic Atractyloside in Herbal Medicines by Decoction. Molecules. 2013; 18(2):2018-2028.

Chicago/Turabian Style

Chen, Liang-Yu; Hu, Anren; Chang, Chih-Jui. 2013. "The Degradation Mechanism of Toxic Atractyloside in Herbal Medicines by Decoction." Molecules 18, no. 2: 2018-2028.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert