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Molecules 2013, 18(2), 2018-2028; doi:10.3390/molecules18022018
Article

The Degradation Mechanism of Toxic Atractyloside in Herbal Medicines by Decoction

1,* , 2 and 3,*
1 Department of Biotechnology, Ming-Chuan University, Guishan, Taoyuan 333, Taiwan 2 Department of Laboratory Medicine and Biotechnology, Tzu-Chi University, Hualien 970, Taiwan 3 Department of Molecular Biology and Human Genetics, Tzu-Chi University, Hualien 970, Taiwan
* Authors to whom correspondence should be addressed.
Received: 12 December 2012 / Revised: 31 January 2013 / Accepted: 1 February 2013 / Published: 5 February 2013
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Abstract

Atractyloside (ATR) is found in many Asteraceae plants that are commonly used as medicinal herbs in China and other eastern Asian countries. ATR binds specifically to the adenine nucleotide translocator in the inner mitochondrial membrane and competitively inhibits ADP and ATP transport. The toxicity of ATR in medical herbs can be reduced by hydrothermal processing, but the mechanisms of ATR degradation are not well understood. In this study, GC-MS coupled with SPE and TMS derivatisation was used to detect ATR levels in traditional Chinese medicinal herbs. Our results suggest that ATR molecules were disrupted by decomposition, hydrolysis and saponification after heating with water (decoction) for a long period of time. Hydrothermal processing could decompose the endogenous toxic compounds and also facilitate the detoxification of raw materials used in the Chinese medicine industry.
Keywords: atractyloside; decoction; herbal medicines atractyloside; decoction; herbal medicines
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chen, L.-Y.; Hu, A.; Chang, C.-J. The Degradation Mechanism of Toxic Atractyloside in Herbal Medicines by Decoction. Molecules 2013, 18, 2018-2028.

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