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Molecules 2013, 18(12), 15182-15192; doi:10.3390/molecules181215182

Efficient PPA-SiO2-catalyzed Synthesis of β-enaminones Under Solvent-Free Conditions

1
Institute of Chemical Sciences, University of Peshawar, Peshawar-25120, Pakistan
2
Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
3
Department of Pharmacy, Kohat University of Science and Technology, Kohat-26000, Pakistan
4
The Patent Office, Karachi 74400, Pakistan
5
Institute of Advanced Technology, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
6
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
*
Authors to whom correspondence should be addressed.
Received: 30 September 2013 / Revised: 14 November 2013 / Accepted: 14 November 2013 / Published: 10 December 2013
(This article belongs to the Section Organic Synthesis)
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Abstract

An efficient method has been developed for the synthesis of β-enaminones under solvent-free reaction conditions using PPA-SiO2 as catalyst. The reaction yields were good to excellent (up to 90%). This methodology affords high selectivity and good tolerance of a variety of different functional groups present on both aromatic and aliphatic amines. In addition, the methodology is environmentally benign and cost-effective due to absence of solvent and easy work-up.
Keywords: solvent free; 5,5-dimethylcyclohexan-1,3-dione; PPA-SiO2; β-enaminones solvent free; 5,5-dimethylcyclohexan-1,3-dione; PPA-SiO2; β-enaminones
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Nisar, M.; Ali, I.; Shah, M.R.; Qayum, M.; Zia-Ul-Haq, M.; Rashid, U.; Islam, M.S. Efficient PPA-SiO2-catalyzed Synthesis of β-enaminones Under Solvent-Free Conditions. Molecules 2013, 18, 15182-15192.

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