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Efficient PPA-SiO2-catalyzed Synthesis of β-enaminones Under Solvent-Free Conditions
Institute of Chemical Sciences, University of Peshawar, Peshawar-25120, Pakistan
Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
Department of Pharmacy, Kohat University of Science and Technology, Kohat-26000, Pakistan
The Patent Office, Karachi 74400, Pakistan
Institute of Advanced Technology, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
* Authors to whom correspondence should be addressed.
Received: 30 September 2013; in revised form: 14 November 2013 / Accepted: 14 November 2013 / Published: 10 December 2013
Abstract: An efficient method has been developed for the synthesis of β-enaminones under solvent-free reaction conditions using PPA-SiO2 as catalyst. The reaction yields were good to excellent (up to 90%). This methodology affords high selectivity and good tolerance of a variety of different functional groups present on both aromatic and aliphatic amines. In addition, the methodology is environmentally benign and cost-effective due to absence of solvent and easy work-up.
Keywords: solvent free; 5,5-dimethylcyclohexan-1,3-dione; PPA-SiO2; β-enaminones
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MDPI and ACS Style
Nisar, M.; Ali, I.; Shah, M.R.; Qayum, M.; Zia-Ul-Haq, M.; Rashid, U.; Islam, M.S. Efficient PPA-SiO2-catalyzed Synthesis of β-enaminones Under Solvent-Free Conditions. Molecules 2013, 18, 15182-15192.
Nisar M, Ali I, Shah MR, Qayum M, Zia-Ul-Haq M, Rashid U, Islam MS. Efficient PPA-SiO2-catalyzed Synthesis of β-enaminones Under Solvent-Free Conditions. Molecules. 2013; 18(12):15182-15192.
Nisar, Muhammad; Ali, Ihsan; Shah, Muhammad R.; Qayum, Mughal; Zia-Ul-Haq, Muhammad; Rashid, Umer; Islam, Md. S. 2013. "Efficient PPA-SiO2-catalyzed Synthesis of β-enaminones Under Solvent-Free Conditions." Molecules 18, no. 12: 15182-15192.