Molecules 2013, 18(12), 15051-15063; doi:10.3390/molecules181215051
Article

Synthesis and Pharmacological Activities of Some New Triazolo- and Tetrazolopyrimidine Derivatives

1, 2,3,* email, 3,4, 3 and 3,5
Received: 27 September 2013; in revised form: 21 November 2013 / Accepted: 29 November 2013 / Published: 6 December 2013
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A new series of fused triazolo- and tetrazolopyrimidine derivatives 214 were synthesized and their anti-inflammatory and ulcerogenic activities were evaluated. The pharmacological screening showed that many of these obtained compounds have good anti-inflammatory activities, comparable to the reference drug. The toxicity of the compounds was also assayed via the determination of their LD50 values. The structures of newly synthesized compounds were confirmed by IR, 1H-NMR, MS spectral data and elemental analysis.
Keywords: pyrazolopyrimidines; thienopyrimidines; triazolo- and tetrazolopyrimidines; anti-inflammatory and ulcerogenic activities
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MDPI and ACS Style

Bahashwan, S.A.; Fayed, A.A.; Amr, A.E.-G.; Flefel, E.M.; Kalmouch, A. Synthesis and Pharmacological Activities of Some New Triazolo- and Tetrazolopyrimidine Derivatives. Molecules 2013, 18, 15051-15063.

AMA Style

Bahashwan SA, Fayed AA, Amr AE-G, Flefel EM, Kalmouch A. Synthesis and Pharmacological Activities of Some New Triazolo- and Tetrazolopyrimidine Derivatives. Molecules. 2013; 18(12):15051-15063.

Chicago/Turabian Style

Bahashwan, Saleh A.; Fayed, Ahmed A.; Amr, Abd E.-G.; Flefel, Eman M.; Kalmouch, Atef. 2013. "Synthesis and Pharmacological Activities of Some New Triazolo- and Tetrazolopyrimidine Derivatives." Molecules 18, no. 12: 15051-15063.

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