Molecules 2013, 18(12), 14496-14504; doi:10.3390/molecules181214496

Three New Ursane-Type Triterpenoids from the Stems of Saprosma merrillii

1 Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China 2 Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210046, Jiangsu, China These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 25 September 2013; in revised form: 13 November 2013 / Accepted: 14 November 2013 / Published: 25 November 2013
(This article belongs to the Section Natural Products)
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Abstract: Three new ursane-type triterpenoids, 3α,6α,30-trihydroxy-ursan-28-oic acid (1), 3α,30-dihydroxy-6-oxo-ursan-28-oic acid (2) and 3α,6α,7α,30-tetrahydroxy-ursan-28-oic acid (3), together with one known triterpenoid, betulinic acid (4), one known anthraquinone, 1,7-dihydroxy-2-methylanthraquinone (5), four known phenols, 1,3,5-trimethoxybenzene (6), p-hydroxybenzoic acid (7), syringic acid (8), isovanillin (9), two steroids, sitosterol (10) and daucosterol (11), were isolated from the ethanol extract of the stems of S. merrillii. Their structures were elucidated on the basis of physical and spectral techniques, besides comparison with literature data. Compounds 13 showed inhibitory activities against the A549, HEPG2, and B16F10 cell lines.
Keywords: Saprosma merrillii; bioassay-guided fractionation; triterpenoid; antineoplastic activity

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MDPI and ACS Style

Zhang, D.; Chen, W.; Chen, W.; Song, X.; Han, C.; Wang, Y.; Chen, G. Three New Ursane-Type Triterpenoids from the Stems of Saprosma merrillii. Molecules 2013, 18, 14496-14504.

AMA Style

Zhang D, Chen W, Chen W, Song X, Han C, Wang Y, Chen G. Three New Ursane-Type Triterpenoids from the Stems of Saprosma merrillii. Molecules. 2013; 18(12):14496-14504.

Chicago/Turabian Style

Zhang, Dashuai; Chen, Wenhao; Chen, Wenxing; Song, Xiaoping; Han, Changri; Wang, Yan; Chen, Guangying. 2013. "Three New Ursane-Type Triterpenoids from the Stems of Saprosma merrillii." Molecules 18, no. 12: 14496-14504.

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