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Three New Ursane-Type Triterpenoids from the Stems of Saprosma merrillii
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China
Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210046, Jiangsu, China
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 25 September 2013; in revised form: 13 November 2013 / Accepted: 14 November 2013 / Published: 25 November 2013
Abstract: Three new ursane-type triterpenoids, 3α,6α,30-trihydroxy-ursan-28-oic acid (1), 3α,30-dihydroxy-6-oxo-ursan-28-oic acid (2) and 3α,6α,7α,30-tetrahydroxy-ursan-28-oic acid (3), together with one known triterpenoid, betulinic acid (4), one known anthraquinone, 1,7-dihydroxy-2-methylanthraquinone (5), four known phenols, 1,3,5-trimethoxybenzene (6), p-hydroxybenzoic acid (7), syringic acid (8), isovanillin (9), two steroids, sitosterol (10) and daucosterol (11), were isolated from the ethanol extract of the stems of S. merrillii. Their structures were elucidated on the basis of physical and spectral techniques, besides comparison with literature data. Compounds 1–3 showed inhibitory activities against the A549, HEPG2, and B16F10 cell lines.
Keywords: Saprosma merrillii; bioassay-guided fractionation; triterpenoid; antineoplastic activity
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Zhang, D.; Chen, W.; Chen, W.; Song, X.; Han, C.; Wang, Y.; Chen, G. Three New Ursane-Type Triterpenoids from the Stems of Saprosma merrillii. Molecules 2013, 18, 14496-14504.
Zhang D, Chen W, Chen W, Song X, Han C, Wang Y, Chen G. Three New Ursane-Type Triterpenoids from the Stems of Saprosma merrillii. Molecules. 2013; 18(12):14496-14504.
Zhang, Dashuai; Chen, Wenhao; Chen, Wenxing; Song, Xiaoping; Han, Changri; Wang, Yan; Chen, Guangying. 2013. "Three New Ursane-Type Triterpenoids from the Stems of Saprosma merrillii." Molecules 18, no. 12: 14496-14504.