Abstract: Three new ursane-type triterpenoids, 3α,6α,30-trihydroxy-ursan-28-oic acid (1), 3α,30-dihydroxy-6-oxo-ursan-28-oic acid (2) and 3α,6α,7α,30-tetrahydroxy-ursan-28-oic acid (3), together with one known triterpenoid, betulinic acid (4), one known anthraquinone, 1,7-dihydroxy-2-methylanthraquinone (5), four known phenols, 1,3,5-trimethoxybenzene (6), p-hydroxybenzoic acid (7), syringic acid (8), isovanillin (9), two steroids, sitosterol (10) and daucosterol (11), were isolated from the ethanol extract of the stems of S. merrillii. Their structures were elucidated on the basis of physical and spectral techniques, besides comparison with literature data. Compounds 1–3 showed inhibitory activities against the A549, HEPG2, and B16F10 cell lines.
Keywords: Saprosma merrillii; bioassay-guided fractionation; triterpenoid; antineoplastic activity
Export to BibTeX
MDPI and ACS Style
Zhang, D.; Chen, W.; Chen, W.; Song, X.; Han, C.; Wang, Y.; Chen, G. Three New Ursane-Type Triterpenoids from the Stems of Saprosma merrillii. Molecules 2013, 18, 14496-14504.
Zhang D, Chen W, Chen W, Song X, Han C, Wang Y, Chen G. Three New Ursane-Type Triterpenoids from the Stems of Saprosma merrillii. Molecules. 2013; 18(12):14496-14504.
Zhang, Dashuai; Chen, Wenhao; Chen, Wenxing; Song, Xiaoping; Han, Changri; Wang, Yan; Chen, Guangying. 2013. "Three New Ursane-Type Triterpenoids from the Stems of Saprosma merrillii." Molecules 18, no. 12: 14496-14504.