Next Article in Journal
Facile Creation of 3-Substituted-3-Hydroxy-2-Oxindoles by Arginine-Catalyzed Aldol Reactions of α,β-Unsaturated Ketones with Isatins
Previous Article in Journal
Cytochrome P450 Family 1 Inhibitors and Structure-Activity Relationships
Correction published on 13 November 2014, see Molecules 2014, 19(11), 18618-18619.

Molecules 2013, 18(12), 14496-14504; doi:10.3390/molecules181214496

Three New Ursane-Type Triterpenoids from the Stems of Saprosma merrillii

1,†, 1,†, 2, 1, 1, 1 and 1,*
1 Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, Hainan, China 2 Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210046, Jiangsu, China These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 25 September 2013 / Revised: 13 November 2013 / Accepted: 14 November 2013 / Published: 25 November 2013
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [330 KB, uploaded 18 June 2014]   |  


Three new ursane-type triterpenoids, 3α,6α,30-trihydroxy-ursan-28-oic acid (1), 3α,30-dihydroxy-6-oxo-ursan-28-oic acid (2) and 3α,6α,7α,30-tetrahydroxy-ursan-28-oic acid (3), together with one known triterpenoid, betulinic acid (4), one known anthraquinone, 1,7-dihydroxy-2-methylanthraquinone (5), four known phenols, 1,3,5-trimethoxybenzene (6), p-hydroxybenzoic acid (7), syringic acid (8), isovanillin (9), two steroids, sitosterol (10) and daucosterol (11), were isolated from the ethanol extract of the stems of S. merrillii. Their structures were elucidated on the basis of physical and spectral techniques, besides comparison with literature data. Compounds 13 showed inhibitory activities against the A549, HEPG2, and B16F10 cell lines.
Keywords: Saprosma merrillii; bioassay-guided fractionation; triterpenoid; antineoplastic activity Saprosma merrillii; bioassay-guided fractionation; triterpenoid; antineoplastic activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Zhang, D.; Chen, W.; Chen, W.; Song, X.; Han, C.; Wang, Y.; Chen, G. Three New Ursane-Type Triterpenoids from the Stems of Saprosma merrillii. Molecules 2013, 18, 14496-14504.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert