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Biological Activity of Propolis-Honey Balm in the Treatment of Experimentally-Evoked Burn Wounds
Department of Anesthesiology and Intensive Care School of Medicine, Medical University of Silesia in Katowice, Medyków 14, 40-752 Katowice, Poland
Department of Women Health, School of Health Sciences, Medical University of Silesia in Katowice, Medyków 12, 40-752 Katowice, Poland
Department of Pharmaceutical Chemistry, School of Pharmacy and Laboratory Medicine, Medical University of Silesia in Katowice, Jagiellońska 4, 41-200 Sosnowiec, Poland
Deparment of Pathology School of Pharmacy and Laboratory Medicine, Medical University of Silesia in Katowice, Ostrogórska 3, 41-200 Sosnowiec, Poland
Department of Hygiene, Bioanalysis and Environmental Studies School of Pharmacy and Laboratory Medicine, Medical University of Silesia in Katowice, Kasztanowa 3A, 41-200 Sosnowiec, Poland
* Author to whom correspondence should be addressed.
Received: 23 September 2013; in revised form: 11 November 2013 / Accepted: 12 November 2013 / Published: 21 November 2013
Abstract: Medicines of biogenic origin with micro-organic, regenerative and analgesic properties are becoming more and more significant in the treatment of burn wounds. These properties are found in apitherapeutics such as propolis and honey—products collected and processed by a honey bee. Their effect on the course of the healing processes is multidirectional. The aim of the study was a histopathological and biochemical analysis of the processes of scar formation in experimentally evoked burn wounds in white pigs treated with the 1% and 3% Sepropol balms containing standardized extracts of propolis and honey. The results were compared with the therapeutic effects obtained with dermazin cream (1% silver sulfadiazine). The level of collagen was determined in the wounds treated with 1% and 3% Sepropol and compared with the collagen level in healthy skin and wounds treated with dermazin. Granulation and regenerated epithelium formation times were compared, with the 3% Sepropol being by far the most effective. The 3% Sepropol also increased the collagen level to 116% with the control sub-groups scoring between 80% and 98%. The results show the healing process of burn wounds in pigs treated with the Sepropol balm starts earlier and has a faster course than the standard dermazin therapy.
Keywords: propolis; bee honey; burn wound; collagen; hydroxyproline
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Jastrzębska-Stojko, Ż.; Stojko, R.; Rzepecka-Stojko, A.; Kabała-Dzik, A.; Stojko, J. Biological Activity of Propolis-Honey Balm in the Treatment of Experimentally-Evoked Burn Wounds. Molecules 2013, 18, 14397-14413.
Jastrzębska-Stojko Ż, Stojko R, Rzepecka-Stojko A, Kabała-Dzik A, Stojko J. Biological Activity of Propolis-Honey Balm in the Treatment of Experimentally-Evoked Burn Wounds. Molecules. 2013; 18(11):14397-14413.
Jastrzębska-Stojko, Żaneta; Stojko, Rafał; Rzepecka-Stojko, Anna; Kabała-Dzik, Agata; Stojko, Jerzy. 2013. "Biological Activity of Propolis-Honey Balm in the Treatment of Experimentally-Evoked Burn Wounds." Molecules 18, no. 11: 14397-14413.