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Molecules 2013, 18(11), 14397-14413; doi:10.3390/molecules181114397

Biological Activity of Propolis-Honey Balm in the Treatment of Experimentally-Evoked Burn Wounds

2,* , 3
Received: 23 September 2013 / Revised: 11 November 2013 / Accepted: 12 November 2013 / Published: 21 November 2013
(This article belongs to the Section Metabolites)
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Medicines of biogenic origin with micro-organic, regenerative and analgesic properties are becoming more and more significant in the treatment of burn wounds. These properties are found in apitherapeutics such as propolis and honey—products collected and processed by a honey bee. Their effect on the course of the healing processes is multidirectional. The aim of the study was a histopathological and biochemical analysis of the processes of scar formation in experimentally evoked burn wounds in white pigs treated with the 1% and 3% Sepropol balms containing standardized extracts of propolis and honey. The results were compared with the therapeutic effects obtained with dermazin cream (1% silver sulfadiazine). The level of collagen was determined in the wounds treated with 1% and 3% Sepropol and compared with the collagen level in healthy skin and wounds treated with dermazin. Granulation and regenerated epithelium formation times were compared, with the 3% Sepropol being by far the most effective. The 3% Sepropol also increased the collagen level to 116% with the control sub-groups scoring between 80% and 98%. The results show the healing process of burn wounds in pigs treated with the Sepropol balm starts earlier and has a faster course than the standard dermazin therapy.
Keywords: propolis; bee honey; burn wound; collagen; hydroxyproline propolis; bee honey; burn wound; collagen; hydroxyproline
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Jastrzębska-Stojko, Ż.; Stojko, R.; Rzepecka-Stojko, A.; Kabała-Dzik, A.; Stojko, J. Biological Activity of Propolis-Honey Balm in the Treatment of Experimentally-Evoked Burn Wounds. Molecules 2013, 18, 14397-14413.

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