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Molecules 2013, 18(11), 14138-14147; doi:10.3390/molecules181114138

Three New Germacrane-Type Sesquiterpenes with NGF-Potentiating Activity from Valeriana officinalis var. latiofolia

1
Department of Pharmaceutical Chemistry, Beijing Institute of Radiation Medicine, Beijing 100850, China
2
Institute of Chemical Defense, Beijing 102205, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 12 October 2013 / Revised: 9 November 2013 / Accepted: 12 November 2013 / Published: 14 November 2013
(This article belongs to the Section Natural Products)
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Abstract

Three new germacrane-type sesquiterpenoids, volvalerenal F (1), volvalerenal G (2) and volvalerenic acid D (3), along with five known compounds 48, were isolated from the CHCl3 soluble partition of the ethanol extract of Valeriana officinalis var. latiofolia. The structures of the new compounds were determined on the basis of spectroscopic evidence, including their 1D- and 2D-NMR spectra, as well as mass spectrometry. The eight germacrane-type sesquiterpenoids showed nerve growth factor (NGF) potentiating activity, which mediates the neurite outgrowth in PC 12D cells. This study intends to reveal the chemical basis of the use of V. officinalis var. latiofolia as a dietary supplement.
Keywords: Valeriana officinalis var. latiofolia; germacrane-type sesquiterpenes; volvalerenal; volvalerenic acid; PC 12D; NGF-potentiating activity Valeriana officinalis var. latiofolia; germacrane-type sesquiterpenes; volvalerenal; volvalerenic acid; PC 12D; NGF-potentiating activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Chen, H.-W.; Chen, L.; Li, B.; Yin, H.-L.; Tian, Y.; Wang, Q.; Xiao, Y.-H.; Dong, J.-X. Three New Germacrane-Type Sesquiterpenes with NGF-Potentiating Activity from Valeriana officinalis var. latiofolia. Molecules 2013, 18, 14138-14147.

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