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Molecules 2013, 18(11), 13860-13869; doi:10.3390/molecules181113860
Article

One-Pot Tandem Synthesis of 2-Arylquinazolines by a Multicomponent Cyclization Reaction

* , ,  and
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China
* Author to whom correspondence should be addressed.
Received: 8 October 2013 / Revised: 21 October 2013 / Accepted: 21 October 2013 / Published: 8 November 2013
(This article belongs to the Section Organic Synthesis)
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Abstract

A series of 2-arylquinazolines have been synthesized in moderate to excellent yields by one-pot tandem reaction of (2-aminophenyl)methanols, aldehydes and ceric ammonium nitrate (CAN). The utility of this transformation was demonstrated by its compatibility with a wide range of functional groups. Thus, the method represents a simple and practical procedure to access 2-arylquinazolines.
Keywords: quinazolines; multicomponent; cyclization reaction; one-pot tandem synthesis quinazolines; multicomponent; cyclization reaction; one-pot tandem synthesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ye, L.; Yu, L.; Zhu, L.; Xia, X. One-Pot Tandem Synthesis of 2-Arylquinazolines by a Multicomponent Cyclization Reaction. Molecules 2013, 18, 13860-13869.

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