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Molecules 2013, 18(11), 13860-13869; doi:10.3390/molecules181113860

One-Pot Tandem Synthesis of 2-Arylquinazolines by a Multicomponent Cyclization Reaction

The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China
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Received: 8 October 2013 / Revised: 21 October 2013 / Accepted: 21 October 2013 / Published: 8 November 2013
(This article belongs to the Section Organic Synthesis)
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Abstract

A series of 2-arylquinazolines have been synthesized in moderate to excellent yields by one-pot tandem reaction of (2-aminophenyl)methanols, aldehydes and ceric ammonium nitrate (CAN). The utility of this transformation was demonstrated by its compatibility with a wide range of functional groups. Thus, the method represents a simple and practical procedure to access 2-arylquinazolines.
Keywords: quinazolines; multicomponent; cyclization reaction; one-pot tandem synthesis quinazolines; multicomponent; cyclization reaction; one-pot tandem synthesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Ye, L.; Yu, L.; Zhu, L.; Xia, X. One-Pot Tandem Synthesis of 2-Arylquinazolines by a Multicomponent Cyclization Reaction. Molecules 2013, 18, 13860-13869.

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