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Molecules 2013, 18(11), 13425-13433; https://doi.org/10.3390/molecules181113425

One-Pot Chemoenzymatic Multicomponent Synthesis of Thiazole Derivatives

College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, Zhejing, China
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Received: 19 August 2013 / Revised: 20 October 2013 / Accepted: 21 October 2013 / Published: 30 October 2013
(This article belongs to the Section Organic Chemistry)
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Abstract

A novel chemoenzymatic one-pot multicomponent synthesis of thiazole derivatives was developed. A series of thiazole derivatives were synthesized with high yields up to 94% under mild enzyme-catalyzed conditions. The blank and control experiments reveal that trypsin from porcine pancreas (PPT) displayed great catalytic activity to promote this reaction and showed a wide tolerance range towards different substrate amines. This trypsin-catalyzed multicomponent conversion method provides a novel strategy to synthesize thiazole derivatives and expands the application of enzymes in organic synthesis. View Full-Text
Keywords: heterocycles; multicomponent; chemoenzymatic; catalysis; thiazole heterocycles; multicomponent; chemoenzymatic; catalysis; thiazole
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Zheng, H.; Mei, Y.-J.; Du, K.; Cao, X.-T.; Zhang, P.-F. One-Pot Chemoenzymatic Multicomponent Synthesis of Thiazole Derivatives. Molecules 2013, 18, 13425-13433.

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