Molecules 2013, 18(11), 13425-13433; doi:10.3390/molecules181113425

One-Pot Chemoenzymatic Multicomponent Synthesis of Thiazole Derivatives

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Received: 19 August 2013; in revised form: 20 October 2013 / Accepted: 21 October 2013 / Published: 30 October 2013
(This article belongs to the Section Organic Synthesis)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A novel chemoenzymatic one-pot multicomponent synthesis of thiazole derivatives was developed. A series of thiazole derivatives were synthesized with high yields up to 94% under mild enzyme-catalyzed conditions. The blank and control experiments reveal that trypsin from porcine pancreas (PPT) displayed great catalytic activity to promote this reaction and showed a wide tolerance range towards different substrate amines. This trypsin-catalyzed multicomponent conversion method provides a novel strategy to synthesize thiazole derivatives and expands the application of enzymes in organic synthesis.
Keywords: heterocycles; multicomponent; chemoenzymatic; catalysis; thiazole
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MDPI and ACS Style

Zheng, H.; Mei, Y.-J.; Du, K.; Cao, X.-T.; Zhang, P.-F. One-Pot Chemoenzymatic Multicomponent Synthesis of Thiazole Derivatives. Molecules 2013, 18, 13425-13433.

AMA Style

Zheng H, Mei Y-J, Du K, Cao X-T, Zhang P-F. One-Pot Chemoenzymatic Multicomponent Synthesis of Thiazole Derivatives. Molecules. 2013; 18(11):13425-13433.

Chicago/Turabian Style

Zheng, Hui; Mei, Yi-Jia; Du, Kui; Cao, Xian-Ting; Zhang, Peng-Fei. 2013. "One-Pot Chemoenzymatic Multicomponent Synthesis of Thiazole Derivatives." Molecules 18, no. 11: 13425-13433.

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