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One-Pot Chemoenzymatic Multicomponent Synthesis of Thiazole Derivatives
College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, Zhejing, China
* Author to whom correspondence should be addressed.
Received: 19 August 2013; in revised form: 20 October 2013 / Accepted: 21 October 2013 / Published: 30 October 2013
Abstract: A novel chemoenzymatic one-pot multicomponent synthesis of thiazole derivatives was developed. A series of thiazole derivatives were synthesized with high yields up to 94% under mild enzyme-catalyzed conditions. The blank and control experiments reveal that trypsin from porcine pancreas (PPT) displayed great catalytic activity to promote this reaction and showed a wide tolerance range towards different substrate amines. This trypsin-catalyzed multicomponent conversion method provides a novel strategy to synthesize thiazole derivatives and expands the application of enzymes in organic synthesis.
Keywords: heterocycles; multicomponent; chemoenzymatic; catalysis; thiazole
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MDPI and ACS Style
Zheng, H.; Mei, Y.-J.; Du, K.; Cao, X.-T.; Zhang, P.-F. One-Pot Chemoenzymatic Multicomponent Synthesis of Thiazole Derivatives. Molecules 2013, 18, 13425-13433.
Zheng H, Mei Y-J, Du K, Cao X-T, Zhang P-F. One-Pot Chemoenzymatic Multicomponent Synthesis of Thiazole Derivatives. Molecules. 2013; 18(11):13425-13433.
Zheng, Hui; Mei, Yi-Jia; Du, Kui; Cao, Xian-Ting; Zhang, Peng-Fei. 2013. "One-Pot Chemoenzymatic Multicomponent Synthesis of Thiazole Derivatives." Molecules 18, no. 11: 13425-13433.