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Molecules 2013, 18(10), 12548-12560; doi:10.3390/molecules181012548
Article

Hypolipidemic and Antioxidant Properties of Phenolic Compound-Rich Extracts from White Ginseng (Panax ginseng) in Cholesterol-Fed Rabbits

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2
 and
1,*
1 Korea Food Research Institute, Seongnam, Kyonggi 463-746, Korea 2 Department of Food Science & Technology, Korea National University of Transportation, Jeungpyeong 368-701, Korea
* Author to whom correspondence should be addressed.
Received: 31 July 2013 / Revised: 26 September 2013 / Accepted: 27 September 2013 / Published: 10 October 2013
(This article belongs to the Section Natural Products)
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Abstract

In this study, the effect of low-molecular weight white ginseng compounds on various biochemical indices, including blood lipid concentrations and antioxidant enzyme activities and morphological changes was investigated in rabbits with high cholesterol diet-induced hypercholesterolemia. The experimental animals were 16-week-old male New Zealand white rabbits divided into normal control diet, high cholesterol diet, and high cholesterol with 0.05% white ginseng low-molecule compound groups, treated for 4 weeks. Blood lipid concentrations were higher in the high cholesterol groups compared to the normal control group but were not improved by the white ginseng low-molecular weight compound. We note however that antioxidant enzyme activities and morphological changes of the aorta showed that white ginseng small compounds had a positive effect on hypercholesterolemia. Based on such results, low-molecular weight compounds rich in phenolic compounds in white ginseng can be said to be effective in part in improving hyperlipidemia and atherosclerosis induced by a high cholesterol diet among New Zealand white rabbits.
Keywords: Panax ginseng; hyperlipidemia; antioxidant activity; atherosclerosis Panax ginseng; hyperlipidemia; antioxidant activity; atherosclerosis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Lee, L.-S.; Cho, C.-W.; Hong, H.-D.; Lee, Y.-C.; Choi, U.-K.; Kim, Y.-C. Hypolipidemic and Antioxidant Properties of Phenolic Compound-Rich Extracts from White Ginseng (Panax ginseng) in Cholesterol-Fed Rabbits. Molecules 2013, 18, 12548-12560.

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