Molecules 2013, 18(10), 12548-12560; doi:10.3390/molecules181012548
Article

Hypolipidemic and Antioxidant Properties of Phenolic Compound-Rich Extracts from White Ginseng (Panax ginseng) in Cholesterol-Fed Rabbits

1email, 1email, 1email, 1email, 2email and 1,* email
Received: 31 July 2013; in revised form: 26 September 2013 / Accepted: 27 September 2013 / Published: 10 October 2013
(This article belongs to the Section Natural Products)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: In this study, the effect of low-molecular weight white ginseng compounds on various biochemical indices, including blood lipid concentrations and antioxidant enzyme activities and morphological changes was investigated in rabbits with high cholesterol diet-induced hypercholesterolemia. The experimental animals were 16-week-old male New Zealand white rabbits divided into normal control diet, high cholesterol diet, and high cholesterol with 0.05% white ginseng low-molecule compound groups, treated for 4 weeks. Blood lipid concentrations were higher in the high cholesterol groups compared to the normal control group but were not improved by the white ginseng low-molecular weight compound. We note however that antioxidant enzyme activities and morphological changes of the aorta showed that white ginseng small compounds had a positive effect on hypercholesterolemia. Based on such results, low-molecular weight compounds rich in phenolic compounds in white ginseng can be said to be effective in part in improving hyperlipidemia and atherosclerosis induced by a high cholesterol diet among New Zealand white rabbits.
Keywords: Panax ginseng; hyperlipidemia; antioxidant activity; atherosclerosis
PDF Full-text Download PDF Full-Text [310 KB, uploaded 18 June 2014 20:12 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Lee, L.-S.; Cho, C.-W.; Hong, H.-D.; Lee, Y.-C.; Choi, U.-K.; Kim, Y.-C. Hypolipidemic and Antioxidant Properties of Phenolic Compound-Rich Extracts from White Ginseng (Panax ginseng) in Cholesterol-Fed Rabbits. Molecules 2013, 18, 12548-12560.

AMA Style

Lee L-S, Cho C-W, Hong H-D, Lee Y-C, Choi U-K, Kim Y-C. Hypolipidemic and Antioxidant Properties of Phenolic Compound-Rich Extracts from White Ginseng (Panax ginseng) in Cholesterol-Fed Rabbits. Molecules. 2013; 18(10):12548-12560.

Chicago/Turabian Style

Lee, Lan-Sook; Cho, Chang-Won; Hong, Hee-Do; Lee, Young-Chul; Choi, Ung-Kyu; Kim, Young-Chan. 2013. "Hypolipidemic and Antioxidant Properties of Phenolic Compound-Rich Extracts from White Ginseng (Panax ginseng) in Cholesterol-Fed Rabbits." Molecules 18, no. 10: 12548-12560.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert