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Molecules 2013, 18(1), 934-950; doi:10.3390/molecules18010934
Article

Total Flavonoids of Scutellaria barbata Inhibit Invasion of Hepatocarcinoma via MMP/TIMP in Vitro

1,†,* , 1,†, 1,†, 2, 1, 1, 1,* , 1,*  and 3,*
Received: 28 November 2012 / Revised: 22 December 2012 / Accepted: 5 January 2013 / Published: 11 January 2013
(This article belongs to the Section Metabolites)
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Abstract

Metastasis is the major cause of cancer-related deaths. Targeting the process of metastasis has been proposed as a strategy to fight cancer. Scutellaria barbata D. Don (S. barbata), a traditional Chinese medicine, is used for treatment of many diseases, including cancer. This study aimed to determine the anti-metastatic effect of total flavonoids of S. barbata (TF-SB) using the human hepatocarcinoma MHCC97H cell line with high metastatic potential. Our results show that TF-SB could significantly inhibit the proliferation and invasion of MHCC97H cells in a dose-dependent manner. MMP-2 and MMP-9 expression were obviously decreased after TF-SB treatment at both the mRNA and protein level. TIMP-1 and TIMP-2 expression were simultaneously increased. The present study indicates that TF-SB could reduce the metastatic capability of MHCC97H cell, probably through decrease of the MMP expression, and simultaneous increase of the TIMP expression.
Keywords: hepatoma; Scutellaria barbata; invasion; metastasis; matrix metalloproteinase hepatoma; Scutellaria barbata; invasion; metastasis; matrix metalloproteinase
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Dai, Z.-J.; Wang, B.-F.; Lu, W.-F.; Wang, Z.-D.; Ma, X.-B.; Min, W.-L.; Kang, H.-F.; Wang, X.-J.; Wu, W.-Y. Total Flavonoids of Scutellaria barbata Inhibit Invasion of Hepatocarcinoma via MMP/TIMP in Vitro. Molecules 2013, 18, 934-950.

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