Molecules 2013, 18(1), 934-950; doi:10.3390/molecules18010934
Article

Total Flavonoids of Scutellaria barbata Inhibit Invasion of Hepatocarcinoma via MMP/TIMP in Vitro

1 Department of Oncology, the Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710004, China 2 Department of General Surgery, the Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710004, China 3 Department of Pharmacology, the Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710004, China These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 28 November 2012; in revised form: 22 December 2012 / Accepted: 5 January 2013 / Published: 11 January 2013
(This article belongs to the Section Natural Products)
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Abstract: Metastasis is the major cause of cancer-related deaths. Targeting the process of metastasis has been proposed as a strategy to fight cancer. Scutellaria barbata D. Don (S. barbata), a traditional Chinese medicine, is used for treatment of many diseases, including cancer. This study aimed to determine the anti-metastatic effect of total flavonoids of S. barbata (TF-SB) using the human hepatocarcinoma MHCC97H cell line with high metastatic potential. Our results show that TF-SB could significantly inhibit the proliferation and invasion of MHCC97H cells in a dose-dependent manner. MMP-2 and MMP-9 expression were obviously decreased after TF-SB treatment at both the mRNA and protein level. TIMP-1 and TIMP-2 expression were simultaneously increased. The present study indicates that TF-SB could reduce the metastatic capability of MHCC97H cell, probably through decrease of the MMP expression, and simultaneous increase of the TIMP expression.
Keywords: hepatoma; Scutellaria barbata; invasion; metastasis; matrix metalloproteinase

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MDPI and ACS Style

Dai, Z.-J.; Wang, B.-F.; Lu, W.-F.; Wang, Z.-D.; Ma, X.-B.; Min, W.-L.; Kang, H.-F.; Wang, X.-J.; Wu, W.-Y. Total Flavonoids of Scutellaria barbata Inhibit Invasion of Hepatocarcinoma via MMP/TIMP in Vitro. Molecules 2013, 18, 934-950.

AMA Style

Dai Z-J, Wang B-F, Lu W-F, Wang Z-D, Ma X-B, Min W-L, Kang H-F, Wang X-J, Wu W-Y. Total Flavonoids of Scutellaria barbata Inhibit Invasion of Hepatocarcinoma via MMP/TIMP in Vitro. Molecules. 2013; 18(1):934-950.

Chicago/Turabian Style

Dai, Zhi-Jun; Wang, Bao-Feng; Lu, Wang-Feng; Wang, Zhi-Dong; Ma, Xiao-Bin; Min, Wei-Li; Kang, Hua-Feng; Wang, Xi-Jing; Wu, Wen-Ying. 2013. "Total Flavonoids of Scutellaria barbata Inhibit Invasion of Hepatocarcinoma via MMP/TIMP in Vitro." Molecules 18, no. 1: 934-950.

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