Abstract: The anti-tumor effect of aconitine in melanoma cell line B16 has been studied in this paper. We found that B16 cells showed significantly reduced growth rates and increased apoptotic effects in the presence of aconitine. Furthermore, aconitine inhibited the PI3K/AKT and MAPK/ERK1/2 signaling pathways, thus regulating the levels of protein and mRNA of PCNA and apoptotic related signaling molecules. Above all, we found that aconitine showed an anti-melanoma effect in suppressing tumor growth in vivo. In conclusion, we show that aconitine may be a useful anticancer drug in the future.
Keywords: melanoma; B16; aconitine; apoptosis; PI3K/AKT; MAPK/ERK1/2
This is an open access article distributed under the
Creative Commons Attribution License which permits unrestricted use, distribution,
and reproduction in any medium, provided the original work is properly cited.
Export to BibTeX
MDPI and ACS Style
Du, J.; Lu, X.; Long, Z.; Zhang, Z.; Zhu, X.; Yang, Y.; Xu, J. In Vitro and in Vivo Anticancer Activity of Aconitine on Melanoma Cell Line B16. Molecules 2013, 18, 757-767.
Du J, Lu X, Long Z, Zhang Z, Zhu X, Yang Y, Xu J. In Vitro and in Vivo Anticancer Activity of Aconitine on Melanoma Cell Line B16. Molecules. 2013; 18(1):757-767.
Du, Juan; Lu, Xiaonian; Long, Ziwen; Zhang, Zhen; Zhu, Xiaohua; Yang, Yongsheng; Xu, Jinhua. 2013. "In Vitro and in Vivo Anticancer Activity of Aconitine on Melanoma Cell Line B16." Molecules 18, no. 1: 757-767.