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In Vitro and in Vivo Anticancer Activity of Aconitine on Melanoma Cell Line B16
Dermatology Department, Huashan Hospital, Fudan University, Shanghai 200040, China
Shanghai Cancer Center, Fudan University, Shanghai 200040, China
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 11 November 2012; in revised form: 29 November 2012 / Accepted: 5 January 2013 / Published: 8 January 2013
Abstract: The anti-tumor effect of aconitine in melanoma cell line B16 has been studied in this paper. We found that B16 cells showed significantly reduced growth rates and increased apoptotic effects in the presence of aconitine. Furthermore, aconitine inhibited the PI3K/AKT and MAPK/ERK1/2 signaling pathways, thus regulating the levels of protein and mRNA of PCNA and apoptotic related signaling molecules. Above all, we found that aconitine showed an anti-melanoma effect in suppressing tumor growth in vivo. In conclusion, we show that aconitine may be a useful anticancer drug in the future.
Keywords: melanoma; B16; aconitine; apoptosis; PI3K/AKT; MAPK/ERK1/2
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Du, J.; Lu, X.; Long, Z.; Zhang, Z.; Zhu, X.; Yang, Y.; Xu, J. In Vitro and in Vivo Anticancer Activity of Aconitine on Melanoma Cell Line B16. Molecules 2013, 18, 757-767.
Du J, Lu X, Long Z, Zhang Z, Zhu X, Yang Y, Xu J. In Vitro and in Vivo Anticancer Activity of Aconitine on Melanoma Cell Line B16. Molecules. 2013; 18(1):757-767.
Du, Juan; Lu, Xiaonian; Long, Ziwen; Zhang, Zhen; Zhu, Xiaohua; Yang, Yongsheng; Xu, Jinhua. 2013. "In Vitro and in Vivo Anticancer Activity of Aconitine on Melanoma Cell Line B16." Molecules 18, no. 1: 757-767.