Molecules 2013, 18(1), 721-734; doi:10.3390/molecules18010721
Article

Synthesis and in Vitro Antiproliferative Activity of New Phenylaminoisoquinolinequinones against Cancer Cell Lines

1, 1, 1, 2 and 1,3,* email
Received: 10 December 2012; in revised form: 27 December 2012 / Accepted: 31 December 2012 / Published: 8 January 2013
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Abstract: A variety of phenylaminoisoquinolinequinones were synthesized and tested for their antiproliferative activity against three human-tumor derived cancer cell lines. The new aminoquinones were prepared from 4-methoxycarbonyl-3-methylisoquinoline-5,8-quinone (1) via acid-induced amination and bromination reactions. Remarkable differences in antiproliferative activity were observed depending upon the location and donor capacity of the substituted phenylamino group at the quinone nucleus. The effect of the substituents on the biological activity is discussed in terms of the donor-acceptor interactions which were evaluated through the redox properties of the aminoquinones.
Keywords: phenylaminoisoquinoline-5,8-quinones; regioselectivity; half-wave potential; antiproliferative activity; SAR analysis
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MDPI and ACS Style

Delgado, V.; Ibacache, A.; Arancibia, V.; Theoduloz, C.; Valderrama, J.A. Synthesis and in Vitro Antiproliferative Activity of New Phenylaminoisoquinolinequinones against Cancer Cell Lines. Molecules 2013, 18, 721-734.

AMA Style

Delgado V, Ibacache A, Arancibia V, Theoduloz C, Valderrama JA. Synthesis and in Vitro Antiproliferative Activity of New Phenylaminoisoquinolinequinones against Cancer Cell Lines. Molecules. 2013; 18(1):721-734.

Chicago/Turabian Style

Delgado, Virginia; Ibacache, Andrea; Arancibia, Verónica; Theoduloz, Cristina; Valderrama, Jaime A. 2013. "Synthesis and in Vitro Antiproliferative Activity of New Phenylaminoisoquinolinequinones against Cancer Cell Lines." Molecules 18, no. 1: 721-734.


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