Molecules 2013, 18(1), 682-689; doi:10.3390/molecules18010682
Article

Diterpenoids with Anti-Inflammatory Activity from the Wood of Cunninghamia konishii

1, 2, 1, 1, 3, 2, 4, 1,* email and 1,5,* email
Received: 11 December 2012; in revised form: 27 December 2012 / Accepted: 28 December 2012 / Published: 4 January 2013
(This article belongs to the Section Metabolites)
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Abstract: Two new diterpenoids, konishone (1) and 3b-hydroxy-5,6-dehydrosugiol (2), along with three known diterpenoids—hinokiol (3), sugiol (4), and 12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (5)—were isolated from the wood of Cunninghamia konishii. Compound 1 is a novel skeleton of the 7,20-dinorabietane-type diterpene. In addition, when RAW264.7 macrophages were treated with different concentrations of compounds 1, 3, and 5 together with LPS, a significant concentration-dependent inhibition of NO production was detected. The IC50 values for inhibition of nitrite production of compounds 1, 3, and 5 were about 9.8 ± 0.7, 7.9 ± 0.9, and 9.3 ± 1.3 μg/mL, respectively. This study presents the potential utilization of compounds 1, 3, and 5, as lead compounds for the development of anti-inflammatory drugs.
Keywords: Cunninghamia konishii; Taxodiaceae; diterpenoid; 7,20-dinorabietane; konishone; 3b-hydroxy-5,6-dehydrosugiol; anti-inflammatory
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chen, Y.-C.; Li, Y.-C.; You, B.-J.; Chang, W.-T.; Chao, L.K.; Lo, L.-C.; Wang, S.-Y.; Huang, G.-J.; Kuo, Y.-H. Diterpenoids with Anti-Inflammatory Activity from the Wood of Cunninghamia konishii. Molecules 2013, 18, 682-689.

AMA Style

Chen Y-C, Li Y-C, You B-J, Chang W-T, Chao LK, Lo L-C, Wang S-Y, Huang G-J, Kuo Y-H. Diterpenoids with Anti-Inflammatory Activity from the Wood of Cunninghamia konishii. Molecules. 2013; 18(1):682-689.

Chicago/Turabian Style

Chen, Yu-Chang; Li, Yen-Cheng; You, Bang-Jau; Chang, Wen-Te; Chao, Louis K.; Lo, Lee-Chiang; Wang, Sheng-Yang; Huang, Guan-Jhong; Kuo, Yueh-Hsiung. 2013. "Diterpenoids with Anti-Inflammatory Activity from the Wood of Cunninghamia konishii." Molecules 18, no. 1: 682-689.


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