Molecules 2013, 18(1), 682-689; doi:10.3390/molecules18010682
Article

Diterpenoids with Anti-Inflammatory Activity from the Wood of Cunninghamia konishii

1 Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan 2 Department of Chemistry, National Taiwan University, Taipei 106, Taiwan 3 Department of Cosmeceutics, College of Pharmacy, China Medical University, Taichung 404, Taiwan 4 Department of Forestry, National Chung Hsing University, Taichung 402, Taiwan 5 Tsuzuki Institute for Traditional Medicine, China Medical University, Taichung 404, Taiwan
* Authors to whom correspondence should be addressed.
Received: 11 December 2012; in revised form: 27 December 2012 / Accepted: 28 December 2012 / Published: 4 January 2013
(This article belongs to the Section Natural Products)
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Abstract: Two new diterpenoids, konishone (1) and 3b-hydroxy-5,6-dehydrosugiol (2), along with three known diterpenoids—hinokiol (3), sugiol (4), and 12-hydroxy-6,7-secoabieta-8,11,13-triene-6,7-dial (5)—were isolated from the wood of Cunninghamia konishii. Compound 1 is a novel skeleton of the 7,20-dinorabietane-type diterpene. In addition, when RAW264.7 macrophages were treated with different concentrations of compounds 1, 3, and 5 together with LPS, a significant concentration-dependent inhibition of NO production was detected. The IC50 values for inhibition of nitrite production of compounds 1, 3, and 5 were about 9.8 ± 0.7, 7.9 ± 0.9, and 9.3 ± 1.3 μg/mL, respectively. This study presents the potential utilization of compounds 1, 3, and 5, as lead compounds for the development of anti-inflammatory drugs.
Keywords: Cunninghamia konishii; Taxodiaceae; diterpenoid; 7,20-dinorabietane; konishone; 3b-hydroxy-5,6-dehydrosugiol; anti-inflammatory

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MDPI and ACS Style

Chen, Y.-C.; Li, Y.-C.; You, B.-J.; Chang, W.-T.; Chao, L.K.; Lo, L.-C.; Wang, S.-Y.; Huang, G.-J.; Kuo, Y.-H. Diterpenoids with Anti-Inflammatory Activity from the Wood of Cunninghamia konishii. Molecules 2013, 18, 682-689.

AMA Style

Chen Y-C, Li Y-C, You B-J, Chang W-T, Chao LK, Lo L-C, Wang S-Y, Huang G-J, Kuo Y-H. Diterpenoids with Anti-Inflammatory Activity from the Wood of Cunninghamia konishii. Molecules. 2013; 18(1):682-689.

Chicago/Turabian Style

Chen, Yu-Chang; Li, Yen-Cheng; You, Bang-Jau; Chang, Wen-Te; Chao, Louis K.; Lo, Lee-Chiang; Wang, Sheng-Yang; Huang, Guan-Jhong; Kuo, Yueh-Hsiung. 2013. "Diterpenoids with Anti-Inflammatory Activity from the Wood of Cunninghamia konishii." Molecules 18, no. 1: 682-689.

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