Molecules 2013, 18(1), 311-321; doi:10.3390/molecules18010311
Communication

Anthraquinones of the Roots of Pentas micrantha

1,2, 2, 2, 3, 1, 2, 2,4,* email and 1,* email
Received: 4 December 2012; in revised form: 19 December 2012 / Accepted: 20 December 2012 / Published: 27 December 2012
(This article belongs to the Special Issue Plant Natural Products against Human Parasites)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Pentas micrantha is used in the East African indigenous medicine to treat malaria. In the first investigation of this plant, the crude methanol root extract showed moderate antiplasmodial activity against the W2- (3.37 μg/mL) and D6-strains (4.00 μg/mL) of Plasmodium falciparum and low cytotoxicity (>450 μg/mL, MCF-7 cell line). Chromatographic separation of the extract yielded nine anthraquinones, of which 5,6-dihydroxylucidin-11-O-methyl ether is new. Isolation of a munjistin derivative from the genus Pentas is reported here for the first time. The isolated constituents were identified by NMR and mass spectrometric techniques and showed low antiplasmodial activities.
Keywords: anthraquinone; malaria; Pentas micrantha; Rubiaceae; 5,6-dihydroxylucidin-11-O-methyl ether
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MDPI and ACS Style

Endale, M.; Ekberg, A.; Alao, J.P.; Akala, H.M.; Ndakala, A.; Sunnerhagen, P.; Erdélyi, M.; Yenesew, A. Anthraquinones of the Roots of Pentas micrantha. Molecules 2013, 18, 311-321.

AMA Style

Endale M, Ekberg A, Alao JP, Akala HM, Ndakala A, Sunnerhagen P, Erdélyi M, Yenesew A. Anthraquinones of the Roots of Pentas micrantha. Molecules. 2013; 18(1):311-321.

Chicago/Turabian Style

Endale, Milkyas; Ekberg, Annabel; Alao, John P.; Akala, Hoseah M.; Ndakala, Albert; Sunnerhagen, Per; Erdélyi, Máté; Yenesew, Abiy. 2013. "Anthraquinones of the Roots of Pentas micrantha." Molecules 18, no. 1: 311-321.

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