Next Article in Journal
Antioxidant Profile of Trifolium pratense L.
Previous Article in Journal
Proximate Composition, Nutritional Attributes and Mineral Composition of Peperomia pellucida L. (Ketumpangan Air) Grown in Malaysia
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2012, 17(9), 11146-11155; doi:10.3390/molecules170911146

Antitrypanosomal Alkaloids from the Marine Bacterium Bacillus pumilus

1
Center for Biodiversity and Drug Discovery, Institute for Scientific Research and High Technology Services, City of Knowledge, P.O. Box 0843-01103, Panama
2
Departamento de Química, Centro de Investigación y de Estudios Avanzados del IPN, México D.F. 07360, Mexico
3
Center for Cellular and Molecular Biology of Diseases, Institute for Scientific Research and High Technology Services, City of Knowledge, P.O. Box 0843-01103, Panama
4
Smithsonian Tropical Research Institute, Balboa, Ancon, P.O. Box 0843-03092, Panama
*
Author to whom correspondence should be addressed.
Received: 18 July 2012 / Revised: 6 September 2012 / Accepted: 7 September 2012 / Published: 18 September 2012
(This article belongs to the Section Natural Products)
Download PDF [210 KB, uploaded 18 June 2014]

Abstract

Fractionation of the ethyl acetate extract of the marine bacterium Bacillus pumilus isolated from the black coral Antipathes sp. led to the isolation of five compounds: cyclo-(L-Leu-L-Pro) (1), 3-hydroxyacetylindole (2), N-acetyl-b-oxotryptamine (3), cyclo-(L-Phe-L-Pro) (4), and 3-formylindole (5). The structures of compounds 15 were established by spectroscopic analyses, including HRESITOF-MS and NMR (1H, 13C, HSQC, HMBC and COSY). Compounds 2, 3 and 5 caused the inhibition on the growth of Trypanosoma cruzi (T. cruzi), with IC50 values of 20.6, 19.4 and 26.9 μM, respectively, with moderate cytotoxicity against Vero cells. Compounds 15 were found to be inactive when tested against Plasmodium falciparum and Leishmania donovani, therefore showing selectivity against T. cruzi parasites.
Keywords: indole alkaloids; Trypanosoma cruzi; Bacillus pumilus; Chagas disease indole alkaloids; Trypanosoma cruzi; Bacillus pumilus; Chagas disease
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Martínez-Luis, S.; Gómez, J.F.; Spadafora, C.; Guzmán, H.M.; Gutiérrez, M. Antitrypanosomal Alkaloids from the Marine Bacterium Bacillus pumilus. Molecules 2012, 17, 11146-11155.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top