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Molecules 2012, 17(9), 11046-11055; doi:10.3390/molecules170911046
Article

Synthesis of Highly Substituted Oxazoles through Iodine(III)-Mediated Reactions of Ketones with Nitriles

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Received: 6 August 2012 / Revised: 29 August 2012 / Accepted: 10 September 2012 / Published: 13 September 2012
(This article belongs to the Special Issue Organic Iodine Chemistry 2012)
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Abstract

In the presence of trifluoromethanesulfonic acid (TfOH) or bis(trifluoromethane-sulfonyl)imide (Tf2NH), iodosobenzene (PhI=O) efficiently promoted the reactions of dicarbonyl compounds as well as monocarbonyl compounds with nitriles to give 2,4-disubstituted and 2,4,5-trisubstituted oxazole in a single step under the mild conditions.
Keywords: single-step synthesis; iodine(III); oxazole; ketone; nitrile single-step synthesis; iodine(III); oxazole; ketone; nitrile
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saito, A.; Hyodo, N.; Hanzawa, Y. Synthesis of Highly Substituted Oxazoles through Iodine(III)-Mediated Reactions of Ketones with Nitriles. Molecules 2012, 17, 11046-11055.

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