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The Effect of Camphor and Borneol on Rat Thymocyte Viability and Oxidative Stress
Department of Chemistry, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria
Institute of Physiology, Faculty of Medicine, University of Nis, Bulevar Dr Zorana Djindjica, 18000 Nis, Serbia
Department of Pharmacy, Faculty of Medicine, University of Nis, Bulevar Dr Zorana Djindjica 81, 18000 Nis, Serbia
Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Build 9, 1113 Sofia, Bulgaria
* Author to whom correspondence should be addressed.
Received: 25 June 2012; in revised form: 25 July 2012 / Accepted: 6 August 2012 / Published: 27 August 2012
Abstract: Camphor and borneol are wildly distributed in the essential oils of medicinal plants from various parts of the World. Our study has been carried out to evaluate the effect of these two bicyclic monoterpenes on rat thymocytes. Camphor and borneol at concentrations of 0.5 and 5 µg/mL did not induce significant toxicity on the immune system cells, while a significant increase of thymocyte viability was detected when cells were incubated with 50 µg/mL of camphor. A significant increase of cell viability was similarly detected when thymocytes were cultivated with borneol at concentrations of 0.5 and 5 µg/mL. The role of camphor and borneol in reactive oxygen species (ROS) production and mitochondrial membrane potential (MMP) disturbances in rat thymocytes as well as their potential mechanism(s) of action were also discussed.
Keywords: camphor; borneol; cytotoxicity; oxidative stress; mitochondrial membrane potential
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Cherneva, E.; Pavlovic, V.; Smelcerovic, A.; Yancheva, D. The Effect of Camphor and Borneol on Rat Thymocyte Viability and Oxidative Stress. Molecules 2012, 17, 10258-10266.
Cherneva E, Pavlovic V, Smelcerovic A, Yancheva D. The Effect of Camphor and Borneol on Rat Thymocyte Viability and Oxidative Stress. Molecules. 2012; 17(9):10258-10266.
Cherneva, Emiliya; Pavlovic, Voja; Smelcerovic, Andrija; Yancheva, Denitsa. 2012. "The Effect of Camphor and Borneol on Rat Thymocyte Viability and Oxidative Stress." Molecules 17, no. 9: 10258-10266.