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• Wen, Z
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• Su, J
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Molecules 2012, 17(9), 10072-10078; doi:10.3390/molecules170910072

Communication

A New Cubitane Diterpenoid from the Soft Coral Sinularia crassa

Ching-Hsiao Cheng ¹ , Yun-Sheng Lin ² , Zhi-Hong Wen ³  and Jui-Hsin Su ^3,4,5,*

¹ Department of Neurosurgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung 833, Taiwan ² Department of Biological Science and Technology, Meiho University, Pingtung 912, Taiwan ³ Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 833, Taiwan ⁴ National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan ⁵ Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan

* Author to whom correspondence should be addressed.

Received: 12 July 2012; in revised form: 10 August 2012 / Accepted: 15 August 2012 / Published: 24 August 2012

(This article belongs to the Section Natural Products)

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Abstract: A new cubitane diterpenoid, crassalone A (1), was isolated from the marine soft coral Sinularia crassa. The structure was determined by extensive spectroscopic analyses. Compound 1 is not cytotoxic (IC₅₀ > 20 μg/mL) toward the four human cancer cell lines tested (HL60, MDA-MB-231, HCT-116 and DLD-1).

Keywords: diterpenes; soft coral; Sinularia crassa

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