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Molecules 2012, 17(9), 10072-10078; doi:10.3390/molecules170910072

A New Cubitane Diterpenoid from the Soft Coral Sinularia crassa

1 Department of Neurosurgery, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Kaohsiung 833, Taiwan 2 Department of Biological Science and Technology, Meiho University, Pingtung 912, Taiwan 3 Department of Marine Biotechnology and Resources and Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 833, Taiwan 4 National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan 5 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
* Author to whom correspondence should be addressed.
Received: 12 July 2012 / Revised: 10 August 2012 / Accepted: 15 August 2012 / Published: 24 August 2012
(This article belongs to the Section Natural Products)
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A new cubitane diterpenoid, crassalone A (1), was isolated from the marine soft coral Sinularia crassa. The structure was determined by extensive spectroscopic analyses. Compound 1 is not cytotoxic (IC50 > 20 μg/mL) toward the four human cancer cell lines tested (HL60, MDA-MB-231, HCT-116 and DLD-1).
Keywords: diterpenes; soft coral; Sinularia crassa diterpenes; soft coral; Sinularia crassa
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cheng, C.-H.; Lin, Y.-S.; Wen, Z.-H.; Su, J.-H. A New Cubitane Diterpenoid from the Soft Coral Sinularia crassa. Molecules 2012, 17, 10072-10078.

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