Straightforward Synthesis of Novel 1-(2′-α-O-D-Glucopyranosyl ethyl) 2-Arylbenzimidazoles
Abstract
:1. Introduction
2. Results and Discussion
Entry | Products | R | Conventional heating | Microwave heating | ||
---|---|---|---|---|---|---|
Time (h) | Yield (%) | Time (min) | Yield (%) | |||
1 | 6a | H | 3.5 | 62 | 3 | 88 |
2 | 6b | o-CH3 | 3 | 65 | 2.5 | 82 |
3 | 6c | p-CH3 | 2.5 | 67 | 2 | 94 |
4 | 6d | p-OCH3 | 3 | 60 | 2 | 89 |
3. Experimental
3.1. General
3.2. General Procedure for the Microwave-Assisted Synthesis of Benzimidazoles 6a–d
3.3. General Procedure for the Synthesis of 1-(2′-α-O-D-glucopyranosyl ethyl) 2-arylbenzimidazoles 8a–d
3.4. General Procedure for the Catalytic Hydrogenolysis
4. Conclusions
Supplementary Materials
Acknowledgments
References
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Arumugam, N.; Abdul Rahim, A.S.; Abd Hamid, S.; Osman, H. Straightforward Synthesis of Novel 1-(2′-α-O-D-Glucopyranosyl ethyl) 2-Arylbenzimidazoles. Molecules 2012, 17, 9887-9899. https://doi.org/10.3390/molecules17089887
Arumugam N, Abdul Rahim AS, Abd Hamid S, Osman H. Straightforward Synthesis of Novel 1-(2′-α-O-D-Glucopyranosyl ethyl) 2-Arylbenzimidazoles. Molecules. 2012; 17(8):9887-9899. https://doi.org/10.3390/molecules17089887
Chicago/Turabian StyleArumugam, Natarajan, Aisyah Saad Abdul Rahim, Shafida Abd Hamid, and Hasnah Osman. 2012. "Straightforward Synthesis of Novel 1-(2′-α-O-D-Glucopyranosyl ethyl) 2-Arylbenzimidazoles" Molecules 17, no. 8: 9887-9899. https://doi.org/10.3390/molecules17089887