Next Article in Journal
Previous Article in Journal
Molecules 2012, 17(8), 9855-9867; doi:10.3390/molecules17089855
Article

The Active Ingredients of Jiang-Zhi-Ning: Study of the Nelumbo nucifera Alkaloids and Their Main Bioactive Metabolites

, , , , , , , , , , , ,  and *
Received: 15 June 2012; in revised form: 12 July 2012 / Accepted: 17 July 2012 / Published: 16 August 2012
View Full-Text   |   Download PDF [385 KB, uploaded 18 June 2014]
Abstract: The object of this study was to identify the major active ingredients of the Chinese Traditional Medicine Jiang-Zhi-Ning (JZN) based on the high performance liquid chromatography (HPLC) profiles of plasma samples obtained from beagle dogs at different times after intragastric administration of JZN, crude JZN extracts, different extracted fractions, different subfractions of the active fraction and different isolated ingredients. 2-Hydroxy-1-methoxyaporphin (2H1M), an alkaloid from Nelumbo nucifera, one of the herbs that make up JZN, was identified as the constituent showing the major pharmacodynamic effect. The major metabolites of 2H1M were analyzed and identified as N-demethyl-2-hydroxy-1-methoxyaporphine-2-O-glycuronic acid, 2-hydroxy-1-methoxy-aporphine-2-O-glycuronic acid and 2-hydroxy-1-methoxy-aporphine-2-O-sulphate. This study provided a comprehensive insight into the active components of JZN.
Keywords: Nelumbo nucifera; alkaloids; Jiang-Zhi-Ning; substantial basis of Traditional Chinese Medicine; 2-hydroxy-1-methoxyaporphin Nelumbo nucifera; alkaloids; Jiang-Zhi-Ning; substantial basis of Traditional Chinese Medicine; 2-hydroxy-1-methoxyaporphin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Chen, J.; Ma, X.; Gao, K.; Wang, Y.; Zhao, H.; Wu, H.; Wang, J.; Xie, H.; OuYang, Y.; Luo, L.; Guo, S.; Han, J.; Liu, B.; Wang, W. The Active Ingredients of Jiang-Zhi-Ning: Study of the Nelumbo nucifera Alkaloids and Their Main Bioactive Metabolites. Molecules 2012, 17, 9855-9867.

AMA Style

Chen J, Ma X, Gao K, Wang Y, Zhao H, Wu H, Wang J, Xie H, OuYang Y, Luo L, Guo S, Han J, Liu B, Wang W. The Active Ingredients of Jiang-Zhi-Ning: Study of the Nelumbo nucifera Alkaloids and Their Main Bioactive Metabolites. Molecules. 2012; 17(8):9855-9867.

Chicago/Turabian Style

Chen, Jianxin; Ma, Xueling; Gao, Kuo; Wang, Yong; Zhao, Huihui; Wu, Hao; Wang, Juan; Xie, Hua; OuYang, Yulin; Luo, Liangtao; Guo, Shuzhen; Han, Jing; Liu, Bing; Wang, Wei. 2012. "The Active Ingredients of Jiang-Zhi-Ning: Study of the Nelumbo nucifera Alkaloids and Their Main Bioactive Metabolites." Molecules 17, no. 8: 9855-9867.



Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert