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Phylattrin, a New Cytotoxic Xanthone from Calophyllum soulattri
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
Faculty of Medicine and Health Science, Universiti Tunku Abdul Rahman, 43000 Kajang, Selangor, Malaysia
Department of Biology, Faculty of Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
* Author to whom correspondence should be addressed.
Received: 30 May 2012; in revised form: 27 June 2012 / Accepted: 28 June 2012 / Published: 10 July 2012
Abstract: Our continuing studies on secondary metabolites from the stem bark of Calophyllum soulattri has led to the isolation of another new diprenylated xanthone, phylattrin (1), in addition to five other xanthones and two common sterols. The xanthones are soulattrin (2), caloxanthone C (3), macluraxanthone (4), brasixanthone B (5) and trapezifolixanthone (6) while the sterols are stigmasterol (7) and β-sitosterol (8). The structures of these compounds were determined on the basis of spectroscopic analyses such as 1D and 2D-NMR, HRESIMS, IR and UV. Compounds 1–7 exhibited moderate cytotoxic activities against SNU-1, HeLa, Hep G2, NCI-H23, K562, Raji, LS174T, IMR-32 and SK-MEL-28 cells.
Keywords: Calophyllum soulattri; Clusiaceae; cytotoxic; phylattrin; xanthone
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Mah, S.H.; Ee, G.C.L.; Teh, S.S.; Rahmani, M.; Lim, Y.M.; Go, R. Phylattrin, a New Cytotoxic Xanthone from Calophyllum soulattri. Molecules 2012, 17, 8303-8311.
Mah SH, Ee GCL, Teh SS, Rahmani M, Lim YM, Go R. Phylattrin, a New Cytotoxic Xanthone from Calophyllum soulattri. Molecules. 2012; 17(7):8303-8311.
Mah, Siau Hui; Ee, Gwendoline Cheng Lian; Teh, Soek Sin; Rahmani, Mawardi; Lim, Yang Mooi; Go, Rusea. 2012. "Phylattrin, a New Cytotoxic Xanthone from Calophyllum soulattri." Molecules 17, no. 7: 8303-8311.