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Molecules 2012, 17(7), 8303-8311; doi:10.3390/molecules17078303

Phylattrin, a New Cytotoxic Xanthone from Calophyllum soulattri

1, 1,* , 1, 1, 2 and 3
Received: 30 May 2012 / Revised: 27 June 2012 / Accepted: 28 June 2012 / Published: 10 July 2012
(This article belongs to the Section Metabolites)
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Our continuing studies on secondary metabolites from the stem bark of Calophyllum soulattri has led to the isolation of another new diprenylated xanthone, phylattrin (1), in addition to five other xanthones and two common sterols. The xanthones are soulattrin (2), caloxanthone C (3), macluraxanthone (4), brasixanthone B (5) and trapezifolixanthone (6) while the sterols are stigmasterol (7) and β-sitosterol (8). The structures of these compounds were determined on the basis of spectroscopic analyses such as 1D and 2D-NMR, HRESIMS, IR and UV. Compounds 17 exhibited moderate cytotoxic activities against SNU-1, HeLa, Hep G2, NCI-H23, K562, Raji, LS174T, IMR-32 and SK-MEL-28 cells.
Keywords: Calophyllum soulattri; Clusiaceae; cytotoxic; phylattrin; xanthone Calophyllum soulattri; Clusiaceae; cytotoxic; phylattrin; xanthone
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mah, S.H.; Ee, G.C.L.; Teh, S.S.; Rahmani, M.; Lim, Y.M.; Go, R. Phylattrin, a New Cytotoxic Xanthone from Calophyllum soulattri. Molecules 2012, 17, 8303-8311.

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