Molecules 2012, 17(5), 6020-6032; doi:10.3390/molecules17056020
Article

Chemical Composition of Artemisia annua L. Leaves and Antioxidant Potential of Extracts as a Function of Extraction Solvents

1 Department of Chemistry, University of Sargodha, Sargodha 40100, Pakistan 2 Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, UPM Serdang 43400, Selangor, Malaysia 3 Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Karachi, Karachi 75270, Pakistan 4 Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang 43400, Selangor, Malaysia
* Author to whom correspondence should be addressed.
Received: 12 April 2012; in revised form: 9 May 2012 / Accepted: 11 May 2012 / Published: 21 May 2012
(This article belongs to the Section Natural Products)
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Abstract: This study was conducted to investigate the chemical and nutritional composition of Artemisia annua leaves in addition to determination of antioxidant potential of their extracts prepared in different solvents. Chemical composition was determined by quantifying fat, protein, carbohydrate, fiber, tocopherol, phytate, and tannin contents. Extraction of A. annua leaves, for antioxidant potential evaluation, was carried out using five solvents of different polarities, i.e., hexane, chloroform, ethyl acetate, methanol and water. Antioxidant potential was evaluated by estimating total phenolic (TPC), flavonoid (TFC) contents, ferric reducing antioxidant power (FRAP), Trolox equivalent antioxidant capacity (TEAC), DPPH radical scavenging activity and lipid peroxidation. Efficiency of different solvents was compared for the yield of antioxidant extracts from leaf samples and a clear variation was observed. The highest TPC, TFC, TEAC, DPPH radical scavenging and lowest lipid peroxidation were observed in MeOH extracts, whereas aqueous extract exhibited high ferric reducing antioxidant power; suggesting MeOH to be the most favorable extractant.
Keywords: Artemisia annua L.; chemical composition; antioxidant activity; solvent effects

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MDPI and ACS Style

Iqbal, S.; Younas, U.; Chan, K.W.; Zia-Ul-Haq, M.; Ismail, M. Chemical Composition of Artemisia annua L. Leaves and Antioxidant Potential of Extracts as a Function of Extraction Solvents. Molecules 2012, 17, 6020-6032.

AMA Style

Iqbal S, Younas U, Chan KW, Zia-Ul-Haq M, Ismail M. Chemical Composition of Artemisia annua L. Leaves and Antioxidant Potential of Extracts as a Function of Extraction Solvents. Molecules. 2012; 17(5):6020-6032.

Chicago/Turabian Style

Iqbal, Shahid; Younas, Umer; Chan, Kim Wei; Zia-Ul-Haq, Muhammad; Ismail, Maznah. 2012. "Chemical Composition of Artemisia annua L. Leaves and Antioxidant Potential of Extracts as a Function of Extraction Solvents." Molecules 17, no. 5: 6020-6032.

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