Next Article in Journal
Stimulatory Action of Cyclooxygenase Inhibitors on Hematopoiesis: A Review
Previous Article in Journal
Microwave Synthesis Under Solvent-Free Conditions and Spectral Studies of Some Mesoporphyrinic Complexes
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2012, 17(5), 5604-5614; doi:10.3390/molecules17055604

Novel Synthesis of 8-Deaza-5,6,7,8-tetrahydroaminopterin Analogues via an Aziridine Intermediate

1
Department of Chemical Biology, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
2
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China
*
Author to whom correspondence should be addressed.
Received: 10 April 2012 / Revised: 3 May 2012 / Accepted: 5 May 2012 / Published: 10 May 2012
Download PDF [307 KB, uploaded 18 June 2014]   |  

Abstract

An efficient method for the construction of the tetrahydrofolate skeleton is described. Starting from pterin analogues and aromatic amines, 8-deaza-5,6,7,8-tetrahydroaminopterin derivatives and the heterocyclic benzoyl isosteres were synthesized via a novel aziridine intermediate. Following this method, the byproducts of carbon-nitrogen bond hydrogenolysis in traditional synthetic strategy can be completely avoided.
Keywords: tetrahydrofolate; aziridine; catalytic hydrogenation; solvent-free tetrahydrofolate; aziridine; catalytic hydrogenation; solvent-free
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zhou, S.; Tian, C.; Li, C.; Guo, Y.; Wang, X.; Liu, J.; Zhang, Z. Novel Synthesis of 8-Deaza-5,6,7,8-tetrahydroaminopterin Analogues via an Aziridine Intermediate. Molecules 2012, 17, 5604-5614.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top