Molecules 2012, 17(5), 5520-5531; doi:10.3390/molecules17055520
Article

Saponins with Neuroprotective Effects from the Roots of Pulsatilla cernua

1,2email, 3, 4, 1,2, 1,5, 1,2,* email, 1,2, 1,2 and 1,2
Received: 1 April 2012; in revised form: 3 May 2012 / Accepted: 4 May 2012 / Published: 9 May 2012
(This article belongs to the Section Metabolites)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Four new oleanene-type triterpenoid saponins together with six known saponins were isolated from the roots of Pulsatilla cernua and their structures were elucidated on the basis of spectroscopic data, including 2D NMR spectra and chemical evidence. Among these one of the aglycones (gypsogenin) is reported for the first time from this genus. Some of these compounds showed significant neuroprotective effects against the cytotoxicity induced by β-amyloid25–35 (Aβ25–35) on human neuroblastoma SH-SY5Y cells.
Keywords: Pulsatilla cernua; saponin; neuroprotective effect; Alzheimer’s disease; β-amyloid
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MDPI and ACS Style

Liu, J.-Y.; Guan, Y.-L.; Zou, L.-B.; Gong, Y.-X.; Hua, H.-M.; Xu, Y.-N.; Zhang, H.; Yu, Z.-G.; Fan, W.-H. Saponins with Neuroprotective Effects from the Roots of Pulsatilla cernua. Molecules 2012, 17, 5520-5531.

AMA Style

Liu J-Y, Guan Y-L, Zou L-B, Gong Y-X, Hua H-M, Xu Y-N, Zhang H, Yu Z-G, Fan W-H. Saponins with Neuroprotective Effects from the Roots of Pulsatilla cernua. Molecules. 2012; 17(5):5520-5531.

Chicago/Turabian Style

Liu, Jian-Yu; Guan, Ying-Li; Zou, Li-Bo; Gong, Yi-Xia; Hua, Hui-Ming; Xu, Yong-Nan; Zhang, Hui; Yu, Zong-Gui; Fan, Wen-Hao. 2012. "Saponins with Neuroprotective Effects from the Roots of Pulsatilla cernua." Molecules 17, no. 5: 5520-5531.


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