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Molecules 2012, 17(5), 5520-5531; doi:10.3390/molecules17055520
Article

Saponins with Neuroprotective Effects from the Roots of Pulsatilla cernua

1,2
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3, 4, 1,2, 1,5, 1,2,* , 1,2, 1,2 and 1,2
1 Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China 2 School of Pharmaceutical Engineer, Shenyang Pharmaceutical University, Shenyang 110016, China 3 Department of Pharmarcy and Food Science, Tonghua Normal University, Tonghua 134000, China 4 Department of Pharmacology, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China 5 School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
* Author to whom correspondence should be addressed.
Received: 1 April 2012 / Revised: 3 May 2012 / Accepted: 4 May 2012 / Published: 9 May 2012
(This article belongs to the Section Natural Products)
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Abstract

Four new oleanene-type triterpenoid saponins together with six known saponins were isolated from the roots of Pulsatilla cernua and their structures were elucidated on the basis of spectroscopic data, including 2D NMR spectra and chemical evidence. Among these one of the aglycones (gypsogenin) is reported for the first time from this genus. Some of these compounds showed significant neuroprotective effects against the cytotoxicity induced by β-amyloid25–35 (Aβ25–35) on human neuroblastoma SH-SY5Y cells.
Keywords: Pulsatilla cernua; saponin; neuroprotective effect; Alzheimer’s disease; β-amyloid Pulsatilla cernua; saponin; neuroprotective effect; Alzheimer’s disease; β-amyloid
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Liu, J.-Y.; Guan, Y.-L.; Zou, L.-B.; Gong, Y.-X.; Hua, H.-M.; Xu, Y.-N.; Zhang, H.; Yu, Z.-G.; Fan, W.-H. Saponins with Neuroprotective Effects from the Roots of Pulsatilla cernua. Molecules 2012, 17, 5520-5531.

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