Molecules 2012, 17(5), 4860-4877; doi:10.3390/molecules17054860
Article

The Antimicrobial Efficacy of Elaeis guineensis: Characterization, in Vitro and in Vivo Studies

1email, 2email, 3email, 1email, 4email and 1,* email
Received: 6 March 2012; in revised form: 14 April 2012 / Accepted: 16 April 2012 / Published: 26 April 2012
(This article belongs to the Section Metabolites)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The urgent need to treat multi-drug resistant pathogenic microorganisms in chronically infected patients has given rise to the development of new antimicrobials from natural resources. We have tested Elaeis guineensis Jacq (Arecaceae) methanol extract against a variety of bacterial, fungal and yeast strains associated with infections. Our studies have demonstrated that E. guineensis exhibits excellent antimicrobial activity in vitro and in vivo against the bacterial and fungal strains tested. A marked inhibitory effect of the E. guineensis extracts was observed against C. albicans whereby E. guineensis extract at ½, 1, or 2 times the MIC significantly inhibited C. albicans growth with a noticeable drop in optical density (OD) of the bacterial culture. This finding confirmed the anticandidal activity of the extract on C. albicans. Imaging using scanning (SEM) and transmission (TEM) electron microscopy was done to determine the major alterations in the microstructure of the extract-treated C. albicans. The main abnormalities noted via SEM and TEM studies were the alteration in morphology of the yeast cells. In vivo antimicrobial activity was studies in mice that had been inoculated with C. albicans and exhibited good anticandidal activity. The authors conclude that the extract may be used as a candidate for the development of anticandidal agent.
Keywords: antimicrobial activity; Candida albicans; Elaeis guineensis; scanning electron microscopy; transmission electron microscopy
PDF Full-text Download PDF Full-Text [1564 KB, Updated Version, uploaded 18 June 2014 19:47 CEST]
The original version is still available [1564 KB, uploaded 18 June 2014 19:47 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Vijayarathna, S.; Zakaria, Z.; Chen, Y.; Latha, L.Y.; Kanwar, J.R.; Sasidharan, S. The Antimicrobial Efficacy of Elaeis guineensis: Characterization, in Vitro and in Vivo Studies. Molecules 2012, 17, 4860-4877.

AMA Style

Vijayarathna S, Zakaria Z, Chen Y, Latha LY, Kanwar JR, Sasidharan S. The Antimicrobial Efficacy of Elaeis guineensis: Characterization, in Vitro and in Vivo Studies. Molecules. 2012; 17(5):4860-4877.

Chicago/Turabian Style

Vijayarathna, Soundararajan; Zakaria, Zuraini; Chen, Yeng; Latha, Lachimanan Yoga; Kanwar, Jagat R.; Sasidharan, Sreenivasan. 2012. "The Antimicrobial Efficacy of Elaeis guineensis: Characterization, in Vitro and in Vivo Studies." Molecules 17, no. 5: 4860-4877.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert