Molecules 2012, 17(3), 2955-2967; doi:10.3390/molecules17032955
Article

Evaluation of Traditional Chinese Medicinal Plants for Anti-MRSA Activity with Reference to the Treatment Record of Infectious Diseases

Guo-Ying Zuo 1,* email, Xin-Juan Zhang 1,2,† email, Cui-Xian Yang 1,3,† email, Jun Han 3 email, Gen-Chun Wang 1,* email and Zhong-Qi Bian 4,* email
1 Research Center for Natural Medicines, Kunming General Hospital, PLA, Kunming 650032, China 2 Kunming Medical College, Kunming 650032, China 3 Yunnan Traditional Chinese Medical College, Kunming 650500, China 4 Center for Infectious Diseases, Kunming General Hospital, PLA, Kunming 650032, China † These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 8 February 2012; in revised form: 27 February 2012 / Accepted: 29 February 2012 / Published: 9 March 2012
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Abstract: The in vitro antimicrobial activities of 30 Chinese medicinal plants were evaluated with reference to the treatment record of infectious diseases in the Traditional Chinese Medicine (TCM) literature. The plant materials were extracted with 80% ethanol and the extracts were primarily screened against conventional clinical pathogens like Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans by the agar diffusion method. Their inhibition zone diameters (IZDs, mm, 50 mg/mL) ranged from 2,048 by the standard broth microdilution method. The seven extracts from M. yunnanensis, S. sinensis, G. morella, E. daneillii, M. squamulata, S. arborescens and B. hancei were determined as the most active extracts, with MICs of 8–64 μg/mL. The results were in good agreement with their traditional applications in skin and other infections.
Keywords: Chinese medicinal plants; traditional Chinese medicine (TCM); methicillin-resistant Staphylococcus aureus (MRSA); inhibition zone diameters (IZD); minimal bactericidal concentrations (MIC)

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Cite This Article

MDPI and ACS Style

Zuo, G.-Y.; Zhang, X.-J.; Yang, C.-X.; Han, J.; Wang, G.-C.; Bian, Z.-Q. Evaluation of Traditional Chinese Medicinal Plants for Anti-MRSA Activity with Reference to the Treatment Record of Infectious Diseases. Molecules 2012, 17, 2955-2967.

AMA Style

Zuo G-Y, Zhang X-J, Yang C-X, Han J, Wang G-C, Bian Z-Q. Evaluation of Traditional Chinese Medicinal Plants for Anti-MRSA Activity with Reference to the Treatment Record of Infectious Diseases. Molecules. 2012; 17(3):2955-2967.

Chicago/Turabian Style

Zuo, Guo-Ying; Zhang, Xin-Juan; Yang, Cui-Xian; Han, Jun; Wang, Gen-Chun; Bian, Zhong-Qi. 2012. "Evaluation of Traditional Chinese Medicinal Plants for Anti-MRSA Activity with Reference to the Treatment Record of Infectious Diseases." Molecules 17, no. 3: 2955-2967.

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