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New Constituents from the Rhizomes of Egyptian Iris germanica L.
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
Department of Natural products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 211589, Saudi Arabia
Department of Pharmacognosy, Faculty of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
Permanent address: Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt
* Author to whom correspondence should be addressed.
Received: 5 February 2012; in revised form: 23 February 2012 / Accepted: 28 February 2012 / Published: 2 March 2012
Abstract: Chemical investigation of the methanolic extract of the rhizomes of Iris germanica L. (Iridaceae) afforded two new compounds; irigenin S (7) and iriside A (12), together with ten known compounds: stigmasterol (1), a-irone (2), γ-irone (3), 3-hydroxy-5-methoxyacetophenone (4), irilone (5), irisolidone (6), irigenin (8), stigmasterol-3-O-β-D-glucopyranoside (9), irilone 4'-O-b-D-glucopyranoside (10) and iridin (11). Their structures were established by UV, IR, 1D (1H and 13C) and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to mass spectroscopic data and comparison with literature data. The methanolic extract was evaluated for its antimicrobial activity. Both the methanolic extract and the isolated flavonoids were tested for their anti-inflammatory activity.
Keywords: Iris germanica L.; Iridaceae; irigenin S; iriside A; antimicrobial; anti-inflammatory
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Ibrahim, S.R.M.; Mohamed, G.A.; Al-Musayeib, N.M. New Constituents from the Rhizomes of Egyptian Iris germanica L.. Molecules 2012, 17, 2587-2598.
Ibrahim SRM, Mohamed GA, Al-Musayeib NM. New Constituents from the Rhizomes of Egyptian Iris germanica L.. Molecules. 2012; 17(3):2587-2598.
Ibrahim, Sabrin R. M.; Mohamed, Gamal A.; Al-Musayeib, Nawal M. 2012. "New Constituents from the Rhizomes of Egyptian Iris germanica L.." Molecules 17, no. 3: 2587-2598.