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Molecules 2012, 17(3), 2567-2578; doi:10.3390/molecules17032567

Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound

1
Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia
2
Faculty of Chemistry, A. Mickiewicz University, Grunwaldzka 6, 60-780 Poznań, Poland
3
Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Njegoševa 12, P.O. Box 815, 11000 Belgrade, Serbia
*
Author to whom correspondence should be addressed.
Received: 16 January 2012 / Revised: 21 February 2012 / Accepted: 28 February 2012 / Published: 2 March 2012
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Abstract

The facile preparation of a racemic hydrazine bridged diphosphonium compound possessing a ring system analogous to bicyclo[3.3.2]decane is reported. Although the reaction yield is low, the structure of the compound, which possesses an eight-membered ring, two phosphonium cationic centers, a biimino bridge, molecular chirality and two fused aromatic rings locked into roughly perpendicular planes is unusual. The compound displays substantial biological activity in the brine shrimp test and cleaves plasmid DNA.
Keywords: hydrazine bridged diphosphonium compound; DNA cleavage; brine shrimp test; X-ray hydrazine bridged diphosphonium compound; DNA cleavage; brine shrimp test; X-ray
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MDPI and ACS Style

Milenković, M.; Warżajtis, B.; Rychlewska, U.; Radanović, D.; Anđelković, K.; Božić, T.; Vujčić, M.; Sladić, D. Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound. Molecules 2012, 17, 2567-2578.

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