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Molecules 2012, 17(3), 2567-2578; doi:10.3390/molecules17032567
Article

Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound

1, 2, 2, 3, 1, 1, 3 and 1,*
Received: 16 January 2012 / Revised: 21 February 2012 / Accepted: 28 February 2012 / Published: 2 March 2012
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Abstract

The facile preparation of a racemic hydrazine bridged diphosphonium compound possessing a ring system analogous to bicyclo[3.3.2]decane is reported. Although the reaction yield is low, the structure of the compound, which possesses an eight-membered ring, two phosphonium cationic centers, a biimino bridge, molecular chirality and two fused aromatic rings locked into roughly perpendicular planes is unusual. The compound displays substantial biological activity in the brine shrimp test and cleaves plasmid DNA.
Keywords: hydrazine bridged diphosphonium compound; DNA cleavage; brine shrimp test; X-ray hydrazine bridged diphosphonium compound; DNA cleavage; brine shrimp test; X-ray
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Milenković, M.; Warżajtis, B.; Rychlewska, U.; Radanović, D.; Anđelković, K.; Božić, T.; Vujčić, M.; Sladić, D. Synthesis, Spectral and Solid State Characterization of a New Bioactive Hydrazine Bridged Cyclic Diphosphonium Compound. Molecules 2012, 17, 2567-2578.

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