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Benefits of Combinations of Vitamin A, C and E Derivatives in the Stability of Cosmetic Formulations
Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Av do Cafe s/n, Monte Alegre, Ribeirao Preto 14040-903, SP, Brazil
* Author to whom correspondence should be addressed.
Received: 19 December 2011; in revised form: 1 February 2012 / Accepted: 16 February 2012 / Published: 22 February 2012
Abstract: Chemically stable ester derivatives of vitamins A, C and E have become a focus of interest for their role in the satisfactory results in skin aging treatments. Accordingly, the aim of this study was to evaluate the physical and chemical stability of a cosmetic formulation containing 1% retinyl palmitate, ascorbyl tetraisopalmitate and tocopheryl acetate, alone or in combination. In the studies of physical stability, a Brookfield rheometer was used to determine rheological behavior of formulations containing the vitamins. Chemical stability was determined by HPLC on a Shimadzu system with UV detection. Results showed that formulations had pseudoplastic behavior and that vitamins did not alter their apparent viscosity and thixotropy. In the chemical stability studies, first-order reaction equations were used for determinations of the shelf-life of vitamins derivatives considering a remaining concentration of 85%. Combined vitamins in a single formulation had a slightly lower degradation rate as compared to different preparations containing only one of the vitamins. Considering that many cosmetic formulations contain vitamin combinations it is suggested that the present study may contribute to the development of more stable formulations containing liposoluble vitamins.
Keywords: stability studies; cosmetics; vitamins; rheology; shelf-life
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Gianeti, M.D.; Gaspar, L.R.; Bueno de Camargo Júnior, F.; Berardo Gonçalves Maia Campos, P.M. Benefits of Combinations of Vitamin A, C and E Derivatives in the Stability of Cosmetic Formulations. Molecules 2012, 17, 2219-2230.
Gianeti MD, Gaspar LR, Bueno de Camargo Júnior F, Berardo Gonçalves Maia Campos PM. Benefits of Combinations of Vitamin A, C and E Derivatives in the Stability of Cosmetic Formulations. Molecules. 2012; 17(2):2219-2230.
Gianeti, Mirela Donato; Gaspar, Lorena Rigo; Bueno de Camargo Júnior, Flávio; Berardo Gonçalves Maia Campos, Patrícia Maria. 2012. "Benefits of Combinations of Vitamin A, C and E Derivatives in the Stability of Cosmetic Formulations." Molecules 17, no. 2: 2219-2230.