Molecules 2012, 17(2), 2082-2090; doi:10.3390/molecules17022082
Article

Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata

1,†email, 2,†email, 3email, 4email, 1email, 5email, 1,* email and 4,* email
Received: 29 November 2011; in revised form: 3 February 2012 / Accepted: 6 February 2012 / Published: 21 February 2012
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3b,7b-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5b,8a,9b,10a,12a)-12-hydroxyatis-16-ene-3,14-dione (6). The structures of compounds 16 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 35 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.
Keywords: Euphorbia formosana; abietane diterpene; MMP-2, -9; HT-1080
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MDPI and ACS Style

Yu, C.-C.; Hsieh, C.-R.; Hsiao, G.; Chen, P.-Y.; Chang, M.-L.; Yin, H.-W.; Lee, T.-H.; Lee, C.-K. Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata. Molecules 2012, 17, 2082-2090.

AMA Style

Yu C-C, Hsieh C-R, Hsiao G, Chen P-Y, Chang M-L, Yin H-W, Lee T-H, Lee C-K. Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata. Molecules. 2012; 17(2):2082-2090.

Chicago/Turabian Style

Yu, Chia-Chun; Hsieh, Ching-Ruey; Hsiao, George; Chen, Pi-Yu; Chang, Meng-Lun; Yin, Hwa-Wen; Lee, Tzong-Huei; Lee, Ching-Kuo. 2012. "Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata." Molecules 17, no. 2: 2082-2090.

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