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Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata
Graduate Institute of Pharmacognosy, Taipei Medical University, 250 Wu Xin Street, Taipei 110, Taiwan
Taipei Medical University Hospital, Taipei Medical University, 252 Wu Xin Street, Taipei 110, Taiwan
Department of Pharmacology, Taipei Medical University, 250 Wu Xin Street, Taipei 110, Taiwan
School of Pharmacy, Taipei Medical University, 250 Wu Xin Street, Taipei 110, Taiwan
Taiwan Forestry Research Institute, No. 53, Nan-Hai Road, Taipei, 100, Taiwan
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 29 November 2011; in revised form: 3 February 2012 / Accepted: 6 February 2012 / Published: 21 February 2012
Abstract: Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3b,7b-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5b,8a,9b,10a,12a)-12-hydroxyatis-16-ene-3,14-dione (6). The structures of compounds 1−6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3−5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.
Keywords: Euphorbia formosana; abietane diterpene; MMP-2, -9; HT-1080
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Yu, C.-C.; Hsieh, C.-R.; Hsiao, G.; Chen, P.-Y.; Chang, M.-L.; Yin, H.-W.; Lee, T.-H.; Lee, C.-K. Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata. Molecules 2012, 17, 2082-2090.
Yu C-C, Hsieh C-R, Hsiao G, Chen P-Y, Chang M-L, Yin H-W, Lee T-H, Lee C-K. Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata. Molecules. 2012; 17(2):2082-2090.
Yu, Chia-Chun; Hsieh, Ching-Ruey; Hsiao, George; Chen, Pi-Yu; Chang, Meng-Lun; Yin, Hwa-Wen; Lee, Tzong-Huei; Lee, Ching-Kuo. 2012. "Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata." Molecules 17, no. 2: 2082-2090.