Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata
AbstractTwo new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3b,7b-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5b,8a,9b,10a,12a)-12-hydroxyatis-16-ene-3,14-dione (6). The structures of compounds 1−6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3−5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.
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Yu, C.-C.; Hsieh, C.-R.; Hsiao, G.; Chen, P.-Y.; Chang, M.-L.; Yin, H.-W.; Lee, T.-H.; Lee, C.-K. Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata. Molecules 2012, 17, 2082-2090.
Yu C-C, Hsieh C-R, Hsiao G, Chen P-Y, Chang M-L, Yin H-W, Lee T-H, Lee C-K. Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata. Molecules. 2012; 17(2):2082-2090.Chicago/Turabian Style
Yu, Chia-Chun; Hsieh, Ching-Ruey; Hsiao, George; Chen, Pi-Yu; Chang, Meng-Lun; Yin, Hwa-Wen; Lee, Tzong-Huei; Lee, Ching-Kuo. 2012. "Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata." Molecules 17, no. 2: 2082-2090.