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Molecules 2012, 17(2), 2082-2090; doi:10.3390/molecules17022082

Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata

1,*  and 4,*
Received: 29 November 2011 / Revised: 3 February 2012 / Accepted: 6 February 2012 / Published: 21 February 2012
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Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3b,7b-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5b,8a,9b,10a,12a)-12-hydroxyatis-16-ene-3,14-dione (6). The structures of compounds 16 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 35 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.
Keywords: Euphorbia formosana; abietane diterpene; MMP-2, -9; HT-1080 Euphorbia formosana; abietane diterpene; MMP-2, -9; HT-1080
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Yu, C.-C.; Hsieh, C.-R.; Hsiao, G.; Chen, P.-Y.; Chang, M.-L.; Yin, H.-W.; Lee, T.-H.; Lee, C.-K. Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata. Molecules 2012, 17, 2082-2090.

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