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Molecules 2012, 17(2), 2082-2090; doi:10.3390/molecules17022082
Article

Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata

1,†
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2,†
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3
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4
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1
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5
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1,*  and 4,*
1 Graduate Institute of Pharmacognosy, Taipei Medical University, 250 Wu Xin Street, Taipei 110, Taiwan 2 Taipei Medical University Hospital, Taipei Medical University, 252 Wu Xin Street, Taipei 110, Taiwan 3 Department of Pharmacology, Taipei Medical University, 250 Wu Xin Street, Taipei 110, Taiwan 4 School of Pharmacy, Taipei Medical University, 250 Wu Xin Street, Taipei 110, Taiwan 5 Taiwan Forestry Research Institute, No. 53, Nan-Hai Road, Taipei, 100, Taiwan These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 29 November 2011 / Revised: 3 February 2012 / Accepted: 6 February 2012 / Published: 21 February 2012
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Abstract

Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3b,7b-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5b,8a,9b,10a,12a)-12-hydroxyatis-16-ene-3,14-dione (6). The structures of compounds 16 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 35 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.
Keywords: Euphorbia formosana; abietane diterpene; MMP-2, -9; HT-1080 Euphorbia formosana; abietane diterpene; MMP-2, -9; HT-1080
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yu, C.-C.; Hsieh, C.-R.; Hsiao, G.; Chen, P.-Y.; Chang, M.-L.; Yin, H.-W.; Lee, T.-H.; Lee, C.-K. Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata. Molecules 2012, 17, 2082-2090.

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