Molecules 2012, 17(2), 2082-2090; doi:10.3390/molecules17022082
Article

Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata

Chia-Chun Yu 1,† email, Ching-Ruey Hsieh 2,† email, George Hsiao 3 email, Pi-Yu Chen 4 email, Meng-Lun Chang 1 email, Hwa-Wen Yin 5 email, Tzong-Huei Lee 1,* email and Ching-Kuo Lee 4,* email
1 Graduate Institute of Pharmacognosy, Taipei Medical University, 250 Wu Xin Street, Taipei 110, Taiwan 2 Taipei Medical University Hospital, Taipei Medical University, 252 Wu Xin Street, Taipei 110, Taiwan 3 Department of Pharmacology, Taipei Medical University, 250 Wu Xin Street, Taipei 110, Taiwan 4 School of Pharmacy, Taipei Medical University, 250 Wu Xin Street, Taipei 110, Taiwan 5 Taiwan Forestry Research Institute, No. 53, Nan-Hai Road, Taipei, 100, Taiwan † These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 29 November 2011; in revised form: 3 February 2012 / Accepted: 6 February 2012 / Published: 21 February 2012
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Abstract: Two new abietane type diterpenoids, namely seco-helioscopinolide (1) and 3b,7b-dihydroxy-ent-abieta-8,13-diene-12,16-olide (2) were isolated from the aerial parts of Euphorbia formosana Hayata together with helioscopinolide A (3), helioscopinolide B (4), helioscopinolide C (5) and ent-(5b,8a,9b,10a,12a)-12-hydroxyatis-16-ene-3,14-dione (6). The structures of compounds 1−6 were elucidated by analyzing their spectroscopic data and comparison with the literature. Further biological tests by gelatin zymographic analysis revealed that 3−5 significantly up-regulated the expressions and activation of MMP-2 and -9 in human fibrosarcoma cell line HT1080.
Keywords: Euphorbia formosana; abietane diterpene; MMP-2, -9; HT-1080

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Cite This Article

MDPI and ACS Style

Yu, C.-C.; Hsieh, C.-R.; Hsiao, G.; Chen, P.-Y.; Chang, M.-L.; Yin, H.-W.; Lee, T.-H.; Lee, C.-K. Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata. Molecules 2012, 17, 2082-2090.

AMA Style

Yu C-C, Hsieh C-R, Hsiao G, Chen P-Y, Chang M-L, Yin H-W, Lee T-H, Lee C-K. Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata. Molecules. 2012; 17(2):2082-2090.

Chicago/Turabian Style

Yu, Chia-Chun; Hsieh, Ching-Ruey; Hsiao, George; Chen, Pi-Yu; Chang, Meng-Lun; Yin, Hwa-Wen; Lee, Tzong-Huei; Lee, Ching-Kuo. 2012. "Regulated Expressions of MMP-2, -9 by Diterpenoids from Euphorbia formosana Hayata." Molecules 17, no. 2: 2082-2090.

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