Molecules 2012, 17(2), 2049-2057; doi:10.3390/molecules17022049
Article

Kramecyne — A New Anti-inflammatory Compound Isolated from Krameria cytisoides

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Received: 13 February 2012; in revised form: 13 February 2012 / Accepted: 14 February 2012 / Published: 20 February 2012
(This article belongs to the Section Metabolites)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: In the present work we describe the structure and anti-inflammatory activity of a new compound, kramecyne, isolated from a methanol extract of Krameria cytisoides (Krameriaceae). The structure of kramecyne was determined by IR, NMR, MS, and elemental analysis, which indicated that the structure corresponded to a hexamer of cyclic peroxide monomers. This compound exhibited good anti-inflammatory activity in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema (51.8 ± 6.9% inhibition) and carrageenan-induced rat paw edema models at doses of 50 mg/kg. The compound significantly reduced edema to 63.1% after 1.0 h, and the effect was unchanged for 5 h. Kramecyne did not present acute toxicity, even at doses of 5,000 mg/kg.
Keywords: anti-inflammatory activity; Krameria; peroxide; polymer; kramecyne
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MDPI and ACS Style

Pérez-Gutiérrez, S.; Sánchez-Mendoza, E.; Martínez-González, D.; Zavala-Sánchez, M.A.; Pérez-González, C. Kramecyne — A New Anti-inflammatory Compound Isolated from Krameria cytisoides. Molecules 2012, 17, 2049-2057.

AMA Style

Pérez-Gutiérrez S, Sánchez-Mendoza E, Martínez-González D, Zavala-Sánchez MA, Pérez-González C. Kramecyne — A New Anti-inflammatory Compound Isolated from Krameria cytisoides. Molecules. 2012; 17(2):2049-2057.

Chicago/Turabian Style

Pérez-Gutiérrez, Salud; Sánchez-Mendoza, Ernesto; Martínez-González, Diana; Zavala-Sánchez, Miguel Angel; Pérez-González, Cuauhtemoc. 2012. "Kramecyne — A New Anti-inflammatory Compound Isolated from Krameria cytisoides." Molecules 17, no. 2: 2049-2057.

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