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Kramecyne — A New Anti-inflammatory Compound Isolated from Krameria cytisoides
Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana-Xochimilco, Calzada del Hueso 1100, Col. Villa Quietud, Coyoacan C.P. 04960, D.F.A.P. 23-181, Mexico
* Author to whom correspondence should be addressed.
Received: 13 February 2012; in revised form: 13 February 2012 / Accepted: 14 February 2012 / Published: 20 February 2012
Abstract: In the present work we describe the structure and anti-inflammatory activity of a new compound, kramecyne, isolated from a methanol extract of Krameria cytisoides (Krameriaceae). The structure of kramecyne was determined by IR, NMR, MS, and elemental analysis, which indicated that the structure corresponded to a hexamer of cyclic peroxide monomers. This compound exhibited good anti-inflammatory activity in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema (51.8 ± 6.9% inhibition) and carrageenan-induced rat paw edema models at doses of 50 mg/kg. The compound significantly reduced edema to 63.1% after 1.0 h, and the effect was unchanged for 5 h. Kramecyne did not present acute toxicity, even at doses of 5,000 mg/kg.
Keywords: anti-inflammatory activity; Krameria; peroxide; polymer; kramecyne
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Pérez-Gutiérrez, S.; Sánchez-Mendoza, E.; Martínez-González, D.; Zavala-Sánchez, M.A.; Pérez-González, C. Kramecyne — A New Anti-inflammatory Compound Isolated from Krameria cytisoides. Molecules 2012, 17, 2049-2057.
Pérez-Gutiérrez S, Sánchez-Mendoza E, Martínez-González D, Zavala-Sánchez MA, Pérez-González C. Kramecyne — A New Anti-inflammatory Compound Isolated from Krameria cytisoides. Molecules. 2012; 17(2):2049-2057.
Pérez-Gutiérrez, Salud; Sánchez-Mendoza, Ernesto; Martínez-González, Diana; Zavala-Sánchez, Miguel Angel; Pérez-González, Cuauhtemoc. 2012. "Kramecyne — A New Anti-inflammatory Compound Isolated from Krameria cytisoides." Molecules 17, no. 2: 2049-2057.