Next Article in Journal
Effects of the Cyclin-Dependent Kinase 10 (CDK10) on the Tamoxifen Sensitivity of Keloid Samples
Previous Article in Journal
Synthesis, Characterization and Cytotoxicity of New Rotundic Acid Derivatives
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Microwave-Assisted Synthesis of New Substituted Anilides of Quinaldic Acid †

1
Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 612 42 Brno, Czech Republic
2
Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic
3
Department of General and Inorganic Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentska 573, 532 10 Pardubice, Czech Republic
*
Author to whom correspondence should be addressed.
Preliminary results were presented at The Fifteenth Electronic Conference on Synthetic Organic Chemistry (ECSOC-15, http://www.sciforum.net/presentation/681), November 1–30, 2011 (paper C681).
Molecules 2012, 17(2), 1292-1306; https://doi.org/10.3390/molecules17021292
Submission received: 21 December 2011 / Revised: 13 January 2012 / Accepted: 16 January 2012 / Published: 31 January 2012

Abstract

:
In this study a one step method for the preparation of substituted anilides of quinoline-2-carboxylic acid was developed. This efficient innovative approach is based on the direct reaction of an acid or ester with substituted anilines using microwave irradiation. The optimized method was used for the synthesis of a series of eighteen substituted quinoline-2-carboxanilides. The molecular structure of N-(4-bromophenyl)quinoline-2-carboxamide as a model compound was determined by single-crystal X-ray diffraction. It crystallizes in the monoclinic space group with four molecules within the unit cell and the total structure of the compound can be described as “a slightly screwed boat”.

1. Introduction

Derivatives of quinoline and its isosteres and analogues are remarkable compounds with many different kinds of biological effects. A number of quinoline-related compounds express antifungal [1,2,3,4], antibacterial [5,6,7], antiviral [8,9,10], antineoplastic [11,12,13,14,15] and other activities [16,17,18].
The stable and polar amide group is an important functionality among the organic substances present in common natural materials like proteins. Moreover, this moiety is found in many synthetic compounds, such as active pharmaceutical ingredients (APIs) or prodrugs [19]. Due to these facts, the amide group is a subject of high interest in drug design and discovery, therefore formation of amides from amines and carboxylic acids and their derivatives is one of the most described transformations. The formation of the amide bond requires activation of a carboxylic acid functional group. The most common methods involve either its activation through acyl chlorides, anhydrides, active esters and other reactive carboxylic acid derivatives or in situ activation by using a large family of various coupling reagents. Although both approaches usually afford satisfactory results, they often need expensive coupling reagents or lead to the formation of by-products requiring further separations [20,21].
Microwave-assisted organic synthesis has been successfully applied in organic and medicinal chemistry over the last decades. The use of microwave irradiation as non-conventional energy source to simplify and improve classic organic reactions has become a very popular method, because it often leads to higher yields, improved conversions, clean product formation and shorter reaction times [22,23,24,25,26,27,28].

2. Results and Discussion

2.1. Chemistry

Substituted quinoline-2-carboxanilides were initially synthesized from quinoline-2-carboxylic acid and corresponding substituted anilines. The activation of carboxylic function was carried out by using an excess of thionyl chloride and catalytic amount of dimethylformamide in standard manner. When this type of activation was performed, in addition to desired acyl chloride 2 undesired chlorinated by-product 3 formed by chlorine attack on position 4 of the quinoline ring was observed (Scheme 1).
Scheme 1. Standard synthesis of quinoline-2-carbonyl chloride (2) together with 4-chloroquinoline-2-carbonyl chloride (3).
Scheme 1. Standard synthesis of quinoline-2-carbonyl chloride (2) together with 4-chloroquinoline-2-carbonyl chloride (3).
Molecules 17 01292 g003
It is well-known that pyridine ring chlorination occurs when pyridinecarboxylic acid is treated with thionyl chloride in the presence of a small amount of anhydrous dimethylformamide. The formed so-called Vilsmeier reagent is well described and used for formation of 4-chloropyridines as intermediates in the synthesis of the multiple kinase inhibitor sorafenib [29]. A method for direct chlorination of quinoline in position 4 has not been described in the literature so far. On the other hand, formation of 4-chloroquinoline derivative hampered our efforts to prepare pure quinoline-2-carboxanilides. When anilides were prepared from the mixture of acyl chlorides 2 and 3 (20–30%), there was no option to separate them other than chromatography. Attempts to optimize reaction conditions (temperature, ratio of reagents, reaction time, etc.) to reduce the amount of undesired intermediate 3 all failed.
Another possibility for the synthesis of the desired quinoline-2-carboxanilides is to perform a direct amidation process starting from an acid or ester precursor and substituted anilines under microwave irradiation [28,30]. Therefore the reaction was performed in a StartSynth microwave reactor using different starting materials. The method was tested on following compounds: quinoline-2-carboxylic acid (1a), 2-naphthoic acid (4a) and their esters methyl quinoline-2-carboxylate (1b), phenyl quinoline-2-carboxylate (1c) and ethyl 2-naphthoate (4b). All those compounds reacted with 4-bromaniline as a model amine to yield the desired products N-(4-bromophenyl)quinoline-2-carboxamide (5c) and N-(4-bromophenyl)naphthalene-2-carboxamide (6), see Scheme 2. The synthesis was performed under various conditions: solvent-free, in dimethylformamide (DMF) or in chlorobenzene (PhCl). All the reactions were performed without or with homo/heterogeneous catalysts: p-toluenesulfonic acid (PTSA), potassium tert-butoxide (tBuOK), silica gel and KF/Al2O3. Microwave output power of the reactor in all experiments was set to 800 W. The reaction temperature was 150 °C in order to shift the equilibrium by water removal. The ratio of an acid derivative and amine was 1:1.5. The reactions were irradiated up to maximum 2 h and were monitored by HPLC analysis. The results are summarized in Table 1.
Scheme 2. Optimization process of synthesis of N-(4-bromophenyl)quinoline-2-carboxamide (5c) and N-(4-bromophenyl)naphthalene-2-carboxamide (6) under microwave irradiation.
Scheme 2. Optimization process of synthesis of N-(4-bromophenyl)quinoline-2-carboxamide (5c) and N-(4-bromophenyl)naphthalene-2-carboxamide (6) under microwave irradiation.
Molecules 17 01292 g004
Table 1. Reaction of 4-bromoaniline with quinoline-2-carboxylic (1a) and naphthalene-2-carboxylic (4a) acids and their derivatives 1b, 1c, 4b under microwave irradiation.
Table 1. Reaction of 4-bromoaniline with quinoline-2-carboxylic (1a) and naphthalene-2-carboxylic (4a) acids and their derivatives 1b, 1c, 4b under microwave irradiation.
Comp.SolventCatalystConversion after 0.5 hConversion after 1 hConversion after 2 h
Amide 5c or 6Product 7 or 8Amide 5c or 6Product 7 or 8Amide 5c or 6Product 7 or 8
1a57%37%aaaa
4a9%
1b6%21%51%
4b
1c96%100%ee
1aDMF
4aDMF
1bDMF
4bDMF
1aPhCl
4aPhCl7%
1bPhCl
4bPhCl
1aPTSA53%46%55%44%33% b67% b
4aPTSA20%46%100% aa
1bPTSA35%aaaa
4bPTSA
1aDMFPTSAc100%c100%c100%
1bDMFPTSAc
4bDMFPTSA
1aPhClPTSA19%24%28%25%32%30%
4aPhClPTSA
1bPhClPTSA20%25%34%
4bPhClPTSA
1atBuOK59%41%61%39%62%38%
4atBuOK11%20%44%
1btBuOK26%74%43% a56% aaa
4btBuOK
1aDMFtBuOK100%100%100%
4aDMFtBuOK
1bDMFtBuOKccc
4bDMFtBuOK
1aPhCltBuOK13%27%30%34%35%41%
4aPhCltBuOK
1bPhCltBuOK17%18%16% b
4bPhCltBuOK
1asilica gel63%37%17%83%53%47%
4asilica gel22%100% d
1bsilica gel11%30%19%19%
4bsilica gel
1aDMFsilica gelccc
4aDMFsilica gel
1bDMFsilica gelc
4bDMFsilica gel
1aPhClsilica gelc26%9%23%68%8%
4aPhClsilica gel
1bPhClsilica gel6%9%
4bPhClsilica gel
1aKF/Al2O390%8%
4aKF/Al2O3cc
1bKF/Al2O310%18%35%
4bKF/Al2O3
1aDMFKF/Al2O373%89%98%
4aDMFKF/Al2O3
1bDMFKF/Al2O3
4bDMFKF/Al2O3
1aPhClKF/Al2O37%24%20%20%
4aPhClKF/Al2O3
1bPhClKF/Al2O3c
4bPhClKF/Al2O3
a decomposition; b partial decomposition; c traces of product; d many impurities; e not performed.
From the first tests it was already evident that the direct amidation of 2-quinaldic acid (1a) is hampered by formation of decarboxylated product—quinoline (7). It was determined that when the reaction was carried out in DMF and catalysed either with PTSA or tBuOK, only decarboxylated compound 7 was produced. On the other hand, in case of 2-naphthoic acid (4a) there no traces of decarboxylated product 8 (naphthalene) were observed.
When the reaction was performed in solvents like DMF or chlorobenzene, it generally did not lead to any improvement. Although the use of methyl ester 1b suppressed decarboxylation, it did not enhance reactivity towards the amides significantly. The same applies to ethyl ester 4b. The results showed that, in almost all cases, the reactions did not proceed cleanly, and the formation of side products and impurities was noticed. Finally, utilization of phenyl ester 1c in reaction with 4-bromo-aniline under microwave irradiation in solvent-free conditions showed spectacular acceleration, high conversion in relatively short reaction time and high product purity. Having optimized the substrate structure and the conditions in hand, the scope of the procedure was consequently evaluated by varying the aniline. Eighteen commercially available ring-substituted anilines were explored as reaction partners to phenyl ester 1c and very good yields (61–89%) and satisfactory purities of products 55c and 913c were obtained. All of the studied compounds were prepared according to Scheme 3.
Scheme 3. Optimized microwave-assisted synthesis of substituted quinoline-2-carboxanilides 5–5c, 9–13c.
Scheme 3. Optimized microwave-assisted synthesis of substituted quinoline-2-carboxanilides 5–5c, 9–13c.
Molecules 17 01292 g005

2.2. Crystallography

N-(4-Bromophenyl)quinoline-2-carboxamide (5c; Figure 1), crystallizes in the monoclinic space group P21/c with four molecules within the unit cell.
Figure 1. Molecular structure (ORTEP 50% probability level) with H-bonding interaction (N(1)-H(1)···N(2) 2.663(3) Å) found in solid state structure. Selected interatomic distances (Ǻ) and angles (°): Br1 C14 1.897(3), C11 N1 1.404(4), N1 C10 1.359(4), C10 C1 1.509(4), C1 N2 1.320(4), N2 C2 1.370(4), O1 C10 1.218(3); C11 N1 C10 127.9(2), N1 C10 O1 125.4(3), N1 C10 C1 113.4(2).
Figure 1. Molecular structure (ORTEP 50% probability level) with H-bonding interaction (N(1)-H(1)···N(2) 2.663(3) Å) found in solid state structure. Selected interatomic distances (Ǻ) and angles (°): Br1 C14 1.897(3), C11 N1 1.404(4), N1 C10 1.359(4), C10 C1 1.509(4), C1 N2 1.320(4), N2 C2 1.370(4), O1 C10 1.218(3); C11 N1 C10 127.9(2), N1 C10 O1 125.4(3), N1 C10 C1 113.4(2).
Molecules 17 01292 g001
The total structure of 5c can be described as a slightly screwed boat with no intermolecular hydrogen bonding. The intramolecular N1-H1···N2 contact is present along with another short contacts forming the 3D structure (Figure 2), instead of a stairs-like supramolecular architecture typical for previously reported members of the families of N-(4-halophenyl)quinoline-2-carboxamides [31] or N-(4-halophenyl)pyridine-2-carboxamides [32,33,34,35].
Figure 2. Supramolecular architecture in X, view along the a axis.
Figure 2. Supramolecular architecture in X, view along the a axis.
Molecules 17 01292 g002
These molecules have typically 2D-layered structures without H-bridges and even π-π stacking. On the other hand, the structure of 5c reveals a weak interaction between the C=O moiety and the coplanar aromatic system of the proximate molecule. The contact between the bromine atom and the perpendicularly oriented π-system of the quinoline ring is probably responsible for the 3D arrangement of molecules.

3. Experimental Section

3.1. General

All chemicals were reagent grade and were purchased from Sigma-Aldrich and Acros. TLC analysis was performed on precoated 60 F254 plates (Merck, Darmstadt, Germany). Compounds were visualized by UV light (254 nm) and evaluated in iodine vapour. Small-scale microwave-assisted synthesis was carried out in a StartSynth multimode microwave instrument producing controlled irradiation at 2.45 GHz (Milestone S.r.l., Sorisole, Italy). The instrument is equipped with an industrial magnetron and a microwave diffuser located above the microwave chamber, with continuous microwave output power from 0 to 1400 W. Reaction times refer to hold times at the temperatures indicated, not to total irradiation times. The temperature was measured with an IR sensor on the outside of the reaction vessel. HPLC monitoring analyses were performed on an Agilent 1200 series HPLC system equipped with a diode array detection (DAD) system, a quarternary model pump and an automatic injector (Agilent Technologies, Santa Clara, CA, USA). ChemStation Chromatography Software was used for data acquisition. Acetonitrile (HPLC grade, Sigma-Aldrich, 50.0%) and H2O (HPLC grade, Sigma-Aldrich, 50.0%) were used as the mobile phase. A Gemini-NX 100 (Phenomenex, Torrance, CA, USA), C18 3 μm, 2.0 × 100 mm chromatographic column was used with a total flow of 0.2 mL/min, an injection volume of 5 μL and a column temperature of 35 °C. A detection wavelength of 230 nm was chosen. The melting points were determined on a Boetius PHMK 05 (VEB Kombinat Nagema, Radebeul, Germany) and are uncorrected. Infrared (IR) spectra were recorded on a Smart MIRacle™ ATR ZnSe for Nicolet™ Impact 410 FT-IR Spectrometer (Thermo Scientific, Waltham, MA, USA). The spectra were obtained by accumulation of 256 scans with 2 cm−1 resolution in the region of 4,000–600 cm−1. All 1H and 13C-NMR spectra were recorded in DMSO-d6 solutions at ambient temperature on a Bruker Avance III 400 MHz spectrometer (Karlsruhe, Bruker, Germany, 400 MHz for 1H, 100 MHz for 13C). Chemical shifts are reported in ppm (δ). Proton chemical shifts in DMSO-d6 are related to the middle of the solvent multiplet (δ = 2.50). 13C-NMR spectra were measured using APT pulse sequences. Carbon chemical shifts are referenced to the middle of the solvent multiplet (δ = 39.5 in DMSO-d6). Mass spectra were measured using a LTQ Orbitrap Hybrid Mass Spectrometer (Thermo Electron Corporation, Waltham, MA, USA) with direct injection into an APCI source (400 °C) in the positive mode.

3.2. Synthesis

3.2.1. Procedure for Classical Synthesis of Ring-substituted Quinoline- and 4-chloroquinoline-2-carboxanilides

Quinoline-2-carboxylic acid (1a, 1.0 g, 5.8 mmol) was suspended in thionyl chloride (2.1 mL, 3.4 g, 28.9 mmol) at room temperature, and DMF (2 drops) was added. The mixture was refluxed for about 3 h and then evaporated to dryness. The residue was used directly in the next step. Into the solution of 2-quinaldic acid chloride in dry toluene (15 mL), triethylamine (4.5 mL, 2.92 g, 32.5 mmol) and the corresponding substituted aniline (5.8 mmol) were added dropwise. The mixture was stirred at room temperature for 24 h, after which the solvent was removed under reduced pressure. The residue was extracted with CHCl3. The combined organic layers were washed with water and saturated aqueous solution of NaHCO3 and dried over anhydrous MgSO4. The solvent was evaporated to dryness under reduced pressure. The crude product and its 4-chloro derivative were isolated by flash chromatography (n-hexane/EtOAc 3: 2) and recrystallized from isopropanol or EtOAc.

3.2.2. Procedure for the Optimization of Microwave-assisted Synthesis

Quinoline-2-carboxylic acid (1a) or naphthalene-2-carboxylic acid (4a) or their esters 1b, 1c, 4b (1.7 mmol) and 4-bromoaniline (0.45 g, 2.6 mmol) were mixed in 10 mL round bottom flask and placed to the microwave reactor. Outlet of the reaction flask was connected with a tube attached to a condenser outside of the microwave reactor. The microwave output power was selected to maximum 800 W. The stirred reaction mixture was preheated to 150 °C by microwave irradiation and let to react at the same temperature for 2 h. The reaction was monitored by HPLC in time periods: 0.5 h, 1 h and 2 h. The results are presented in Table 1.

3.2.3. General Procedure for Microwave-assisted Synthesis of Ring-substituted Quinoline-2-carboxanilides

Phenyl quinoline-2-carboxylate (1c, 250 mg, 1.0 mmol) and substituted aniline (1.5 mmol) were mixed in 10 mL round bottom flask and placed to the microwave reactor. Outlet of the reaction flask was connected with a tube attached to a condenser outside of the microwave reactor. The microwave output power was selected to maximum 800 W in order to avoid the observed pyrolysis problems. The stirred reaction mixture was preheated to 150 °C by microwave irradiation and let to react at the same temperature for 1 h. After cooling, the reaction mixture was diluted with chloroform (20 mL), washed with saturated sodium bicarbonate solution (2 × 10 mL) and brine (10 mL). The organic phase was then dried over anhydrous Na2SO4 and the solvent was removed under reduced pressure. The crude product was recrystallized from isopropanol to yield pure substituted quinoline-2-carboxanilides 55c, 913c.
N-(2-Bromophenyl)quinoline-2-carboxamide (5a). Yield 61%; Mp. 134–135 °C; IR (Zn/Se ATR, cm−1): 3277w, 1689s, 1588m, 1579m, 1543m, 1530s, 1496m, 1440m, 1427m, 1302w, 1132w, 1204m, 908w, 842m, 768s, 736m, 698m; 1H-NMR (DMSO-d6), δ: 10.82 (bs, 1H), 8.60 (d, J = 8.5 Hz, 1H), 8.44 (d, J = 8.3 Hz, 1H), 8.23 (d, J = 8.5 Hz, 1H), 8.13 (d, J = 8.5 Hz, 1H), 8.07 (d, J = 8.3 Hz, 1H), 7.87 (t, J = 7.5 Hz, 1H), 7.64–7.77 (m, 2H), 7.44 (t, J = 7.8 Hz, 1H), 7.10 (t, J = 7.7 Hz, 1H); 13C-NMR (DMSO-d6), δ: 161.61, 148.71, 145.50, 138.60, 135.46, 132.58, 130.83, 129.26, 129.13, 128.55, 128.53, 128.08, 125.74, 121.39, 118.19, 114.08; HR-MS: for C16H12BrN2O [M+H]+ calculated 327.0133 m/z, found 327.0138 m/z.
N-(3-Bromophenyl)quinoline-2-carboxamide (5b). Yield 75%; Mp. 139–140 °C; IR (Zn/Se ATR, cm−1): 3318w, 1687m, 1581m, 1519m, 1478w, 1408m, 1296w, 1124m, 1067w, 912w, 847m, 764s, 685m; 1H-NMR (DMSO-d6), δ: 10.89 (bs, 1H), 8.60 (d, J = 8.3 Hz, 1H), 8.19–8.32 (m, 3H), 8.09 (d, J = 8.0 Hz, 1H), 7.96 (d, J = 7.5 Hz, 1H), 7.87–7.93 (m, 1H), 7.68–7.78 (m, 1H), 7.27–7.40 (m, 2H); 13C-NMR (DMSO-d6), δ: 163.02, 149.67, 145.86, 139.98, 138.21, 130.69, 130.67, 129.32, 128.97, 128.44, 128.14, 126.59, 122.66, 121.55, 119.14, 118.77; HR-MS: for C16H12BrN2O [M+H]+ calculated 327.0133 m/z, found 327.0143 m/z.
N-(4-Bromophenyl)quinoline-2-carboxamide (5c). Yield 88%; Mp. 157–158 °C; IR (Zn/Se ATR, cm−1): 3355w, 1693s, 1581m, 1522s, 1496s, 1423w, 1389m, 1305w, 1120m, 1095w, 1068m, 998w, 907w, 839s, 807s, 769s, 693w; 1H-NMR (DMSO-d6), δ: 10.84 (bs, 1H), 8.58 (d, J = 8.5 Hz, 1H), 8.18–8.30 (m, 2H), 8.07 (d, J = 8.3 Hz, 1H), 7.95 (d, J = 8.8 Hz, 2H), 7.86–7.92 (m, 1H), 7.67–7.78 (m, 1H), 7.56 (d, J = 8.8 Hz, 2H); 13C-NMR (DMSO-d6), δ: 162.86, 149.82, 145.87, 138.16, 137.74, 131.53, 130.64, 129.33, 128.94, 128.37, 128.12, 122.28, 118.77, 115.80; HR-MS: for C16H12BrN2O [M+H]+ calculated 327.0133 m/z, found 327.0129 m/z.
N-(2-Chlorophenyl)quinoline-2-carboxamide (9a) [36]. Yield 70%; Mp. 130–131 °C; 1H-NMR (DMSO-d6), δ: 10.77 (bs, 1H), 8.58 (d, J = 8.5 Hz, 1H), 8.43 (d, J = 8.0 Hz, 1H), 8.21 (d, J = 8.5 Hz, 1H), 8.10 (d, J = 8.5 Hz, 1H), 8.05 (d, J = 8.3 Hz, 1H), 7.85 (t, J = 7.5 Hz, 1H), 7.64–7.75 (m, 1H), 7.54 (d, J = 7.8 Hz, 1H), 7.39 (t, J = 7.7 Hz, 1H), 7.10–7.24 (m, 1H); 13C-NMR (DMSO-d6), δ: 161.54, 148.70, 145.47, 138.50, 134.21, 130.75, 129.29, 129.20, 129.07, 128.46, 128.00, 127.88, 125.23, 123.38, 121.27, 118.15; HR-MS: for C16H12ClN2O [M+H]+ calculated 283.0638 m/z, found 283.0652 m/z.
N-(3-Chlorophenyl)quinoline-2-carboxamide (9b) [36]. Yield 80%; Mp. 127–128 °C; 1H-NMR (DMSO-d6), δ: 10.90 (bs, 1H), 8.58 (d, J = 8.5 Hz, 1H), 8.18–8.31 (m, 2H), 8.15 (s, 1H), 8.07 (d, J = 8.0 Hz, 1H), 7.82–7.97 (m, 2H), 7.66–7.78 (m, 1H), 7.40 (t, J = 8.0 Hz, 1H), 7.11–7.23 (m, 1H); 13C-NMR (DMSO-d6), δ: 163.02, 149.67, 145.87, 139.85, 138.20, 133.12, 130.68, 130.36, 129.34, 128.98, 128.43, 128.14, 123.70, 119.82, 118.77; HR-MS: for C16H12ClN2O [M+H]+ calculated 283.0638 m/z, found 283.0648 m/z.
N-(4-Chlorophenyl)quinoline-2-carboxamide (9c). Yield 80%; Mp. 134–135 °C (Mp. 135–135.5 °C [37]); 1H-NMR (DMSO-d6), δ: 10.88 (bs, 1H), 8.58 (d, J = 8.5 Hz, 1H), 8.17–8.30 (m, 2H), 8.08 (d, J = 8.0 Hz, 1H), 8.01 (d, J = 8.8 Hz, 2H), 7.84–7.93 (m, 1H), 7.68–7.77 (m, 1H), 7.43 (d, J = 8.8 Hz, 2H); 13C-NMR (DMSO-d6), δ: 162.87, 149.85, 145.88, 138.16, 137.34, 130.65, 129.34, 128.95, 128.62, 128.37, 128.14, 127.69, 121.92, 118.78; HR-MS: for C16H12ClN2O [M+H]+ calculated 283.0638 m/z, found 283.0631 m/z.
N-(2-Fluorophenyl)quinoline-2-carboxamide (10a). Yield 63%; Mp. 116–117 °C; IR (Zn/Se ATR, cm−1): 3328w, 1691m, 1615m, 1591w, 1530s, 1504m, 1477w, 1454m, 1428m, 1317w, 1247w, 1185w, 1126m, 1088w, 910w, 837m, 772s, 746s, 683m; 1H-NMR (DMSO-d6), δ: 10.48 (bs, 1H), 8.57 (d, J = 8.5 Hz, 1H), 8.17–8.25 (m, 2H), 8.13 (d, J = 8.5 Hz, 1H), 8.05 (d, J = 8.0 Hz, 1H), 7.85 (t, J = 7.3 Hz, 1H), 7.65–7.76 (m, 1H), 7.28–7.40 (m, 1H), 7.13–7.27 (m, 2H); 13C-NMR (DMSO-d6), δ: 162.00, 153.58 (d, 1JFC = 244 Hz), 148.95, 145.67, 138.39, 130.76, 129.24, 129.15 (d, 2JFC = 19.1 Hz), 128.45, 128.08, 125.70 (d, 3JFC = 11.0 Hz), 125.53 (d, 3JFC = 7.3 Hz), 124.63 (d, 4JFC = 3.7 Hz), 122.91, 118.37, 115.43 (d, 2JFC = 19.1 Hz); HR-MS: for C16H12FN2O [M+H]+ calculated 267.0934 m/z, found 267.0950 m/z.
N-(3-Fluorophenyl)quinoline-2-carboxamide (10b). Yield 81%; Mp. 126–127 °C; IR (Zn/Se ATR, cm−1): 3343w, 1690s, 1588m, 1531s, 1504m, 1481s, 1409s, 1170m, 1137m, 899m, 841s, 791m, 768s, 738m, 682s; 1H-NMR (DMSO-d6), δ: 10.91 (bs, 1H), 8.58 (d, J = 8.5 Hz, 1H), 8.16–8.31 (m, 2H), 8.08 (d, J = 8.3 Hz, 1H), 7.95 (d, J = 11.8 Hz, 1H), 7.86–7.92 (m, 1H), 7.79 (d, J = 8.3 Hz, 1H), 7.68–7.75 (m, 1H), 7.35–7.49 (m, 1H), 6.96 (td, J = 8.4 Hz, J = 2.0 Hz, 1H); 13C-NMR (DMSO-d6), δ: 163.01, 162.15 (d, 1JFC =241 Hz), 149.73, 145.86, 140.11 (d, 3JFC =11.0 Hz), 138.18, 130.65, 130.31 (d, 3JFC = 9.5 Hz), 129.33, 128.97, 128.39, 128.12, 118.77, 116.15 (d, 4JFC = 2.9 Hz), 110.47 (d, 2JFC = 21.3 Hz), 107.09 (d, 2JFC = 26.4 Hz); HR-MS: for C16H12FN2O [M+H]+ calculated 267.0934 m/z, found 267.0953 m/z.
N-(4-Fluorophenyl)quinoline-2-carboxamide (10c) [36,38]. Yield 81%; Mp. 115–116 °C; 1H-NMR (DMSO-d6), δ: 10.83 (bs, 1H), 8.57 (d, J = 8.3 Hz, 1H), 8.17–8.29 (m, 2H), 8.06 (d, J = 8.0 Hz, 1H), 7.94–8.02 (m, 2H), 7.87 (td, J = 7.7 Hz, J = 1.3 Hz, 1H), 7.66–7.76 (m, 1H), 7.17–7.28 (m, 2H); 13C-NMR (DMSO-d6), δ: 162.76, 158.58 (d, 1JFC = 237 Hz), 150.03, 145.95, 138.18, 134.81 (d, 4JFC = 2.2 Hz), 130.67, 129.39, 128.98, 128.37, 128.17, 122.31 (d, 3JFC = 7.3 Hz), 118.83, 115.26 (d, 2JFC = 22.7 Hz); HR-MS: for C16H12FN2O [M+H]+ calculated 267.0934 m/z, found 267.0954 m/z.
N-(2-Methoxyphenyl)quinoline-2-carboxamide (11a) [39]. Yield 79%; Mp. 111–112 °C; IR (Zn/Se ATR, cm−1): 3382w, 1676s, 1596m, 1532s, 1485w, 1454m, 1426m, 1334w, 1288w, 1253m, 1138m, 1129m, 1093w, 1020s, 951w, 908m, 873w, 840m, 820w, 770s, 732s; 1H-NMR (DMSO-d6), δ: 10.68 (bs, 1H), 8.59 (d, J = 8.5 Hz, 1H), 8.49 (d, J = 7.8 Hz, 1H), 8.25 (d, J = 8.5 Hz, 1H), 8.15 (d, J = 8.5 Hz, 1H), 8.07 (d, J = 8.3 Hz, 1H), 7.87 (t, J = 7.3 Hz, 1H), 7.67–7.75 (m, 1H), 7.11 (d, J = 4.0 Hz, 2H), 7.01 (dt, J = 8.2 Hz, J = 4.2 Hz, 1H), 3.98 (s, 3H); 13C-NMR (DMSO-d6), δ: 161.25, 149.34, 148.51, 145.62, 138.55, 130.82, 129.30, 129.06, 128.44, 128.14, 126.87, 124.25, 120.68, 118.84, 118.27, 110.91, 56.05; HR-MS: for C17H15N2O2 [M+H]+ calculated 279.1134 m/z, found 279.1148 m/z.
N-(3-Methoxyphenyl)quinoline-2-carboxamide (11b). Yield 77%; Mp. 117–118 °C; IR (Zn/Se ATR, cm−1): 3352w, 1687m, 1589m, 1524m, 1503m, 1456m, 1425m, 1334w, 1284m, 1203m, 1157m, 1128m, 1049s, 906w, 876m, 854m, 823w, 798w, 762s, 740s, 685m; 1H-NMR (DMSO-d6), δ: 10.73 (bs, 1H), 8.58 (d, J = 8.5 Hz, 1H), 8.19–8.32 (m, 2H), 8.07 (d, J = 8.0 Hz, 1H), 7.82–7.96 (m, 1H), 7.65–7.79 (m, 2H), 7.59 (dd, J = 8.0 Hz, J = 1.0 Hz, 1H), 7.29 (t, J = 8.2 Hz, 1H), 6.72 (dd, J = 8.3 Hz, J = 2.01 Hz, 1H), 3.78 (s, 3H); 13C-NMR (DMSO-d6), δ: 162.70, 159.61, 149.99, 145.88, 139.53, 138.23, 130.67, 129.61, 129.37, 128.97, 128.37, 128.16, 118.75, 112.47, 109.68, 105.91, 55.09; HR-MS: for C17H15N2O2 [M+H]+ calculated 279.1134 m/z, found 279.1129 m/z.
N-(4-Methoxyphenyl)quinoline-2-carboxamide (11c) [36]. Yield 84%; Mp. 130–131 °C; 1H-NMR (DMSO-d6), δ: 10.65 (bs, 1H), 8.57 (d, J = 8.5 Hz, 1H), 8.24 (d, J = 8.5 Hz, 2H), 8.07 (d, J = 7.8 Hz, 1H), 7.82–7.95 (m, 3H), 7.63–7.78 (m, 1H), 6.97 (d, J = 9.0 Hz, 2H), 3.75 (s, 3H); 13C-NMR (DMSO-d6), δ: 162.28, 155.80, 150.25, 145.90, 138.09, 131.47, 130.59, 129.32, 128.87, 128.22, 128.11, 121.85, 118.73, 113.87, 55.17; HR-MS: for C17H15N2O2 [M+H]+ calculated 279.1134 m/z, found 279.1145 m/z.
N-(2-Methylphenyl)quinoline-2-carboxamide (12a). Yield 71%; Mp. 100–101 °C; IR (Zn/Se ATR, cm−1): 3334w, 1686s, 1587s, 1528s, 1498M, 1454s, 1427s, 1422m, 1373w, 1305m, 1249w, 1201w, 1132m, 1091w, 1040w, 1013w, 981w, 954m, 932w, 907m, 872m, 842s, 793w, 765s, 750s, 731s, 681s; 1H-NMR (DMSO-d6), δ: 10.45 (bs, 1H), 8.60 (d, J = 8.5 Hz, 1H), 8.24 (d, J = 8.5 Hz, 1H), 8.17 (d, J = 8.3 Hz, 1H), 8.08 (d, J = 8.0 Hz, 1H), 7.95 (d, J = 7.8 Hz, 1H), 7.83–7.91 (m, 1H), 7.69–7.77 (m, 1H), 7.22–7.31 (m, 2H), 7.08–7.16 (m, 1H), 2.37 (s, 3H); 13C-NMR (DMSO-d6), δ: 161.92, 149.67, 145.74, 138.35, 135.97, 130.72, 130.42, 130.01, 129.38, 129.01, 128.38, 128.11, 126.40, 124.96, 122.65, 118.49, 17.49; HR-MS: for C17H15N2O [M+H]+ calculated 263.1184 m/z, found 263.1182 m/z.
N-(3-Methylphenyl)quinoline-2-carboxamide (12b). Yield 65%; Mp. 82–83 °C; IR (Zn/Se ATR, cm−1): 3355w, 1685m, 1592m, 1527s, 1503s 1457w, 1424m, 1300w, 1171w, 1125m, 908w, 852m, 773s, 740w, 690s; 1H-NMR (DMSO-d6), δ: 10.66 (bs, 1H), 8.61 (d, J = 8.5 Hz, 1H), 8.25 (dd, J = 7.9 Hz, J = 5.40 Hz, 2H), 8.10 (d, J = 8.0 Hz, 1H), 7.90 (t, J = 7.5 Hz, 1H), 7.67–7.84 (m, 3H), 7.27 (t, J = 7.7 Hz, 1H), 6.96 (d, J = 7.3 Hz, 1H), 2.32 (s, 3H); 13C-NMR (DMSO-d6), δ: 162.54, 150.03, 145.88, 138.22, 138.20, 138.03, 130.68, 129.35, 128.94, 128.65, 128.35, 128.15, 124.75, 120.72, 118.70, 117.35, 21.23; HR-MS: for C17H15N2O [M+H]+ calculated 263.1184 m/z, found 263.1191 m/z.
N-(4-Methylphenyl)quinoline-2-carboxamide (12c). Yield 89%; Mp. 107–108 °C (Mp. 109.5–110 °C [37]); 1H-NMR (DMSO-d6), δ: 10.67 (bs, 1H), 8.59 (d, J = 8.5 Hz, 1H), 8.18–8.30 (m, 2H), 8.08 (d, J = 8.0 Hz, 1H), 7.79–7.94 (m, 3H), 7.72 (t, J = 7.4 Hz, 1H), 7.18 (d, J = 8.3 Hz, 2H), 2.27 (s, 3H); 13C-NMR (DMSO-d6), δ: 162.51, 150.17, 145.93, 138.21, 135.86, 133.09, 130.69, 129.39, 129.24, 128.94, 128.35, 128.18, 120.27, 118.77, 20.59; HR-MS: for C17H15N2O [M+H]+ calculated 263.1184 m/z, found 263.1193 m/z.
N-(2-Trifluoromethylphenyl)quinoline-2-carboxamide (13a). Yield 74%; Mp. 120–121 °C; IR (Zn/Se ATR, cm−1): 3316w, 1698s, 1590s, 1537s, 1498w, 1452m, 1423m, 1320m, 1288m, 1244w, 1202w, 1165m, 1124m, 1094m, 1054m, 1026m, 953w, 906w, 871w, 836m, 792w, 763s, 676m; 1H-NMR (DMSO-d6), δ: 10.78 (bs, 1H), 8.61 (d, J = 8.3 Hz, 1H), 8.36 (d, J = 8.3 Hz, 1H), 8.23 (d, J = 8.3 Hz, 1H), 8.07 (t, J = 8.3 Hz, 2H), 7.87 (t, J = 7.5 Hz, 1H), 7.64–7.81 (m, 3H), 7.38 (t, J = 7.7 Hz, 1H); 13C-NMR (DMSO-d6), δ: 162.05, 148.48, 145.53, 138.74, 135.14, 133.57, 131.01, 129.48 (q, 2JFC = 37 Hz), 129.21, 129.17, 128.68, 128.16, 126.41 (q, 3JFC = 5.1 Hz), 125.05, 124.10 (q, 1JFC = 274 Hz), 123.89 (q, 3JFC = 5.9 Hz), 118.31; HR-MS: for C17H12F3N2O [M+H]+ calculated 317.0902 m/z, found 317.0891 m/z.
N-(3-Trifluoromethylphenyl)quinoline-2-carboxamide (13b). Yield 71%; Mp. 121–122 °C; IR (Zn/Se ATR, cm−1): 3339w, 1692s, 1614w, 1536m, 1490m, 1424w, 1330s, 1223w, 1166m, 1109s, 1091s, 1065m, 952w, 933w, 874s, 844m, 08s, 771s, 744w, 698s; 1H-NMR (DMSO-d6), δ: 11.08 (bs, 1H), 8.59 (d, J = 8.5 Hz, 1H), 8.46 (s, 1H), 8.17–8.31 (m, 3H), 8.08 (d, J = 8.0 Hz, 1H), 7.89 (t, J = 7.4 Hz, 1 H), 7.68–7.78 (m, 1 H), 7.61 (t, J = 8.0 Hz, 1 H), 7.46 (d, J = 7.5 Hz, 1H); 13C-NMR (DMSO-d6), δ: 163.26, 149.64, 145.90, 139.23, 138.21, 130.69, 129.86, 129.35 (q, 2JFC = 32 Hz), 129.34, 129.03, 128.45, 128.16, 124.20 (q, 1JFC = 273 Hz), 123.91, 120.24 (q, 3JFC = 3.7 Hz), 118.78, 116.61 (q, 3JFC = 3.7 Hz); HR-MS: for C17H12F3N2O [M+H]+ calculated 317.0902 m/z, found 317.0892 m/z.
N-(4-Trifluoromethylphenyl)quinoline-2-carboxamide (13c) [38,40]. Yield 87%; Mp. 147‑148 °C; 1H-NMR (DMSO-d6), δ: 11.02 (bs, 1H), 8.59 (d, J = 8.3 Hz, 1H), 8.26 (d, J = 8.5 Hz, 1H), 8.23 (d, J = 8.3 Hz, 1H), 8.19 (d, J = 8.5 Hz, 2H), 8.08 (d, J = 8.0 Hz, 1H), 7.86–7.93 (m, 1H), 7.69–7.77 (m, 3H); 13C-NMR (DMSO-d6), δ: 163.27, 149.63, 145.88, 141.95, 138.23, 130.69, 129.38, 129.03, 128.48, 128.14, 125.96 (q, 3JFC = 3.7 Hz), 124.39 (q, 1JFC = 271 Hz), 124.00 (q, 2JFC = 32 Hz), 120.29, 118.81; HR-MS: for C17H12F3N2O [M+H]+ calculated 317.0902 m/z, found 317.0890 m/z.

3.3. Crystallography

The X-ray data for the colourless crystal of 5c were obtained at 150 K using Oxford Cryostream low-temperature device on a Nonius KappaCCD diffractometer with MoKα radiation (λ = 0.71073 Å), a graphite monochromator and the ϕ and χ scan mode. Data reductions were performed with DENZO-SMN [41]. The absorption was corrected by integration methods [42]. Structures were solved by direct methods (Sir92) [43] and refined by full matrix least-square based on F2 (SHELXL97) [44]. Hydrogen atoms were mostly localized on a difference Fourier map, however to ensure uniformity of the treatment of the crystal, all hydrogen atoms were recalculated into idealized positions (riding model) and assigned temperature factors Hiso(H) = 1.2 Ueq(pivot atom) or 1.5 Ueq for the methyl moiety with C–H = 0.93 Å for hydrogen atoms in aromatic rings moiety and N–H being 0.86 Å. Crystallographic data for 5c: C16H11BrN2O, M = 327.18, monoclinic, P21/c, a = 6.3620(2), b = 16.9968(7), c = 12.6001(10) Å, β = 105.892(5)°, Z = 4, V = 1310.42(13) Å3, Dc = 1.658 g·cm−3, μ = 3.133 mm−1, Tmin/Tmax = 0.559/0.671; −8 ≤ h ≥ 7, −20 ≤ k ≥ 22, −15 ≤ l ≥ 16; 9690 reflections measured (θmax = 27.4°), 2941 independent (Rint = 0.0428), 2246 with I > 2 σ (I), 181 parameters, S = 1.159, R1(obs. data) = 0.0404, wR2(all data) = 0.0672; max., min. residual electron density = 0.324, −0.389 eÅ−3.
Crystallographic data for structural analysis have been deposited with the Cambridge Crystallographic Data Centre under CCDC deposition number: 858014. Copies of this information may be obtained free of charge from the Director, CCDC, 12 Union Road, Cambridge CB2 1EY, UK (fax: +44-1223-336033; e-mail: [email protected] or www: http://www.ccdc.cam.ac.uk).

4. Conclusions

A novel microwave-assisted one-pot coupling of phenyl ester of 2-quinaldic acid (1c) and ring-substituted anilines was successfully developed. This method provided an efficient approach for the synthesis of substituted quinoline-2-carboxanilides in solvent-free conditions. Interestingly, the reactions were applied and verified to eighteen substituted anilines. Desired carboxanilides were isolated in high yields and purities. In the solid state of N-(4-bromophenyl)quinoline-2-carboxamide (5c) only typical intramolecular N1-H1···N2 contact was observed. The structure of 5c shows that there is no strong intermolecular interaction. Compound 5c is the first structure of this type of compounds with 3D organisation due to several short contacts. In general, the developed microwave-assisted solvent-free procedure for preparation of aromatic amides in good yields using a simple and efficient approach may find broad applicability in synthesis of various substrates containing amide functions.

Supplementary Materials

Supplementary materials can be accessed at: https://www.mdpi.com/1420-3049/17/2/1292/s1.

Acknowledgements

This study was supported by the IGA VFU Brno 49/2011/FaF and the Ministry of Education, Youth and Sports of the Czech Republic (Project MSM 0021627501).
  • Sample Availability: Samples of the compounds are available from the authors.

References and Notes

  1. Kharkar, P.S.; Deodhar, M.N.; Kulkarni, V.M. Design, synthesis, antifungal activity, and ADME prediction of functional analogues of terbinafine. Med. Chem. Res. 2009, 18, 421–432. [Google Scholar]
  2. Musiol, R.; Jampilek, J.; Buchta, V.; Niedbala, H.; Podeszwa, B.; Palka, A.; Majerz-Maniecka, K.; Oleksyn, B.; Polanski, J. Antifungal properties of new series of quinoline derivatives. Bioorg. Med. Chem. 2006, 14, 3592–3598. [Google Scholar] [CrossRef]
  3. Musiol, R.; Serda, M.; Hensel-Bielowka, S.; Polanski, J. Quinoline-based antifungals. Curr. Med. Chem. 2010, 17, 1960–1973. [Google Scholar]
  4. Nakamoto, K.; Tsukada, I.; Tanaka, K.; Matsukura, M.; Haneda, T.; Inoue, S.; Murai, N.; Abe, S.; Ueda, N.; Miyazaki, M.; et al. Synthesis and evaluation of novel antifungal agents-quinoline and pyridine amide derivatives. Bioorg. Med. Chem. Lett. 2010, 20, 4624–4626. [Google Scholar]
  5. Oliva, B.; Miller, K.; Caggiano, N.; O’Neill, A.J.; Cuny, G.D.; Hoemarm, M.Z.; Hauske, J.R.; Chopra, I. Biological properties of novel antistaphylococcal quinoline-indole agents. Antimicrob. Agents Chemother. 2003, 47, 458–466. [Google Scholar]
  6. Upadhayaya, R.S.; Vandavasi, J.K.; Kardile, R.A.; Lahore, S.V.; Dixit, S.S.; Deokar, H.S.; Shinde, P.D.; Sarmah, M.P.; Chattopadhyaya, J. Novel quinoline and naphthalene derivatives as potent antimycobacterial agents. Eur. J. Med. Chem. 2010, 45, 1854–1867. [Google Scholar]
  7. Jampilek, J.; Musiol, R.; Pesko, M.; Kralova, K.; Vejsova, M.; Carroll, J.; Coffey, A.; Finster, J.; Tabak, D.; Niedbala, H.; et al. Ring-substituted 4-hydroxy-1H-quinolin-2-ones: Preparation and biological activity. Molecules 2009, 14, 1145–1159. [Google Scholar]
  8. Vaillancourt, V.A.; Cudahy, M.M.; Staley, S.A.; Brideau, R.J.; Conrad, S.J.; Knechtel, M.L.; Oien, N.L.; Wieber, J.L.; Yagi, Y.; Wathen, M.W. Naphthalene carboxamides as inhibitors of human cytomegalovirus DNA polymerization. Bioorg. Med. Chem. Lett. 2000, 10, 2079–2081. [Google Scholar]
  9. Brideau, R.J.; Knechtel, M.L.; Huang, A.; Vaillancourt, V.A.; Vera, E.E.; Oien, N.L.; Hopkins, T.A.; Wieber, J.L.; Wilkinson, K.F.; Rush, B.D.; et al. Broad-spectrum antiviral activity of PNU-183792, a 4-oxo-dihydroquinoline, against human and animal herpesviruses. Antivir. Res. 2002, 54, 19–28. [Google Scholar]
  10. Oien, N.L.; Brideau, R.J.; Hopkins, T.A.; Wieber, J.L.; Knechtel, M.L.; Shelly, J.A.; Anstadt, R.A.; Wells, P.A.; Poorman, R.A.; Huang, A.; et al. Broad-spectrum antiherpes activities of 4-hydroxyquinoline carboxamides, a novel class of herpesvirus polymerase inhibitors. Antimicrob. Agents Chemother. 2002, 46, 724–730. [Google Scholar]
  11. Podeszwa, B.; Niedbala, H.; Polanski, J.; Musiol, R.; Tabak, D.; Finster, J.; Serafin, K.; Wietrzyk, J.; Boryczka, S.; Mol, W.; et al. Investigating the antiproliferative activity of quinoline-5,8-dione analogues on tumour cell lines. Bioorg. Med. Chem. Lett. 2007, 17, 6138–6141. [Google Scholar]
  12. Shi, A.; Nguyen, T.A.; Battina, S.K.; Rana, S.; Takemoto, D.J.; Chiang, P.K.; Hua, D.H. Synthesis and anti-breast cancer activities of substituted quinolines. Bioorg. Med. Chem. Lett. 2008, 18, 3364–3368. [Google Scholar]
  13. Gakhar, G.; Shi, A.; Hua, D.H.; Nguyen, T.A. Antitumor effect of substituted quinolines in breast cancer cells. Drug Dev. Res. 2008, 69, 526–534. [Google Scholar]
  14. Mrozek-Wilczkiewicz, A.; Kalinowski, D.; Musiol, R.; Finster, J.; Szurko, A.; Serafin, K.; Knas, M.; Kamalapuram, S.K.; Kovacevic, Z.; Jampilek, J.; et al. Investigating anti-proliferative activity of styrylazanaphthalenes and azanaphthalenediones. Bioorg. Med. Chem. 2010, 18, 2664–2671. [Google Scholar]
  15. Bernzweig, J.; Heiniger, B.; Prasain, K.; Lu, J.; Hua, D.H.; Nguyen, T.A. Anti-breast cancer agents, quinolines, targeting gap junction author. Med. Chem. 2011, 7, 448–453. [Google Scholar]
  16. Foley, M.; Tilley, L. Quinoline antimalarials: Mechanisms of action and resistance and prospects for new agents. Pharmacol. Ther. 1998, 79, 55–87. [Google Scholar]
  17. Nakayama, H.; Loiseau, P.M.; Bories, C.; Torres de Ortiz, S.; Schinini, A.; Serna, E.; Rojas de Arias, A.; Fakhfakh, M.A.; Franck, X.; Figadere, B.; et al. Efficacy of orally administered 2-substituted quinolines in experimental murine cutaneous and visceral leishmaniases. Antimicrob. Agents Chemother. 2005, 49, 4950–4956. [Google Scholar]
  18. Kaur, K.; Jain, M.; Reddy, R.P.; Jain, R. Quinolines and structurally related heterocycles as antimalarials. Eur. J. Med. Chem. 2010, 45, 3245–3264. [Google Scholar]
  19. Rautio, J.; Kumpulainen, H.; Heimbach, T.; Oliyai, R.; Oh, D.; Jarvinen, T.; Savolainen, J. Prodrugs: Design and clinical applications. Nat. Rev. Drug Discov. 2008, 7, 255–270. [Google Scholar]
  20. Comprehensive Organic Synthesis; Trost, B.M.; Fleming, I.; Winterfeldt, E. (Eds.) Pergamon Press: Oxford, UK, 1991; Volume 6, pp. 301–399.
  21. Katritzky, A.R.; Suzuki, K.; Singh, S.K. N-Acylation in combinatorial chemistry. ARKIVOC 2004, i, 12–35. [Google Scholar]
  22. Lidstrom, P.; Tierney, J.P.; Wathey, B.; Westman, J. Microwave assisted organic synthesis—A review. Tetrahedron 2001, 57, 9225–9283. [Google Scholar]
  23. Microwave Assisted Organic Synthesis; Tierney, J.P.; Lidstrom, P. (Eds.) Blackwell Publishing: Oxford, UK, 2005.
  24. de la Hoz, A.; Diaz-Ortiz, A.; Moreno, A. Microwaves in organic synthesis. Thermal and non-thermal microwave effects. Chem. Soc. Rev. 2005, 34, 164–178. [Google Scholar]
  25. Hayes, B.L. Microwave Synthesis: Chemistry at the Speed of Light; CEM Publishing: Matthews, NC, USA, 2002. [Google Scholar]
  26. Microwaves in Organic Synthesis; Loupy, A. (Ed.) Wiley-VCH: Weinheim, Germany, 2002.
  27. Varma, R.S. Advances in Green Chemistry: Chemical Syntheses using Microwave Irradiation; Varma, R.S., Ed.; AstraZeneca Research Foundation, Kavitha Printers: Bangalore, India, 2002. [Google Scholar]
  28. Bogdal, D. Microwave-assisted Organic Synthesis One Hundred Reaction Procedures; Elsevier: Oxford, UK, 2005. [Google Scholar]
  29. Bankston, D.; Dumas, J.; Natero, R.; Riedl, B.; Monahan, M.-K.; Sibley, R. A scaleable synthesis of BAY 43-9006: A potent Raf kinase inhibitor for the treatment of cancer. Org. Process. Res. Dev. 2002, 6, 777–781. [Google Scholar] [CrossRef]
  30. Perreux, L.; Loupy, A.; Volatron, F. Solvent-free preparation of amides from acids and primary amines under microwave irradiation. Tetrahedron 2002, 58, 2155–2162. [Google Scholar]
  31. Qi, J.Y.; Qiu, L.Q.; Yang, Q.Y.; Zhou, Z.Y.; Chan, A.S.C. N-(4-Iodophenyl)quinoline-2-carboxamide. Acta Crystallogr. E 2003, 59, o104–o105. [Google Scholar]
  32. Mocilac, P.; Lough, A.J.; Gallagher, J.F. Structures and conformational analysis of a 3 × 3 isomer grid of nine N-(fluorophenyl)pyridinecarboxamides. Cryst. Eng. Comm. 2011, 13, 1899–1999. [Google Scholar]
  33. Wilson, C.R.; Munro, O.Q. Unconventional hydrogen bonding and π-stacking in two substituted pyridine carboxamides. Acta Crystallogr. C 2010, 66, o513–o516. [Google Scholar] [CrossRef]
  34. Qi, J.Y.; Yang, Q.Y.; Lam, K.H.; Zhou, Z.Y.; Chan, A.S.C. N-(4-Bromophenyl)pyridine-2-carboxamide. Acta Crystallogr. E 2003, 59, o374–o375. [Google Scholar]
  35. Zhang, Q.; Zhang, S.P.; Shao, S.C. N-(4-Chlorophenyl)picolinamide. Acta Crystallogr. E 2006, 62, o4695–o4696. [Google Scholar]
  36. Schaefer, W.; Neubert, P. Mass spectra of heterocyclic carboxylic acid amides. I. Pyridine- and quinolinecarboxylic acid anilides. Tetrahedron 1969, 25, 315–327. [Google Scholar] [CrossRef]
  37. Davis, J.W., Jr. Studies with quinolines. I. Synthesis of quinaldic acid and some of its amide derivatives. J. Org. Chem. 1959, 24, 1691–1694. [Google Scholar] [CrossRef]
  38. Petrie, C.; Orme, M.W.; Baindur, N.; Robbins, K.G.; Harris, S.M.; Kontoyianni, M.; Hurley, L.H.; Kerwin, S.M.; Mundy, G.R. Compositions and Methods for Treating Bone Deficit Conditions. PCT Int. Appl. WO 9715308 A1, 1 May 1997. [Google Scholar]
  39. Chan, L.; Jin, H.; Stefanac, T.; Wang, W.; Lavallee, J.F.; Bedard, J.; May, S. Isoquinoline-6-carboxamides as potent and selective anti-human cytomegalovirus (HCMV) inhibitors. Bioorg. Med. Chem. Lett. 1999, 9, 2583–2586. [Google Scholar] [CrossRef]
  40. Kiselyov, A.S. Reaction of N-fluoropyridinium fluoride with isonitriles and TMSN3: A convenient one-pot synthesis of tetrazol-5-yl pyridines. Tetrahedron Lett. 2005, 46, 4851–4854. [Google Scholar] [CrossRef]
  41. Otwinowski, Z.; Minor, W. Processing of X-ray diffraction data collected in oscillation mode. In Methods in Enzymology 276: Macromolecular Crystallography, Part A; Carter, C.W., Jr., Sweet, R.M., Eds.; Academic Press: New York, NY, USA, 1997; pp. 307–326. [Google Scholar]
  42. Coppens, P. The Evaluation of Absorption and Extinction in Single Crystal Structure Analysis. In Crystallographic Computing; Ahmed, F.R., Hall, S.R., Huber, C.P., Eds.; Munksgaard: Copenhagen, Denmark, 1970; pp. 255–270. [Google Scholar]
  43. Altomare, A.; Cascarano, G.; Giacovazzo, C.; Guagliardi, A. Completion and refinement of crystal-structures with SIR92. J. Appl. Crystallogr. 1993, 26, 343–350. [Google Scholar] [CrossRef]
  44. Sheldrick, G.M. SHELXL-97; University of Gottingen: Gottingen, Germany, 1997. [Google Scholar]

Share and Cite

MDPI and ACS Style

Bobal, P.; Sujan, J.; Otevrel, J.; Imramovsky, A.; Padelkova, Z.; Jampilek, J. Microwave-Assisted Synthesis of New Substituted Anilides of Quinaldic Acid. Molecules 2012, 17, 1292-1306. https://doi.org/10.3390/molecules17021292

AMA Style

Bobal P, Sujan J, Otevrel J, Imramovsky A, Padelkova Z, Jampilek J. Microwave-Assisted Synthesis of New Substituted Anilides of Quinaldic Acid. Molecules. 2012; 17(2):1292-1306. https://doi.org/10.3390/molecules17021292

Chicago/Turabian Style

Bobal, Pavel, Josef Sujan, Jan Otevrel, Ales Imramovsky, Zdenka Padelkova, and Josef Jampilek. 2012. "Microwave-Assisted Synthesis of New Substituted Anilides of Quinaldic Acid" Molecules 17, no. 2: 1292-1306. https://doi.org/10.3390/molecules17021292

Article Metrics

Back to TopTop