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Molecules 2012, 17(2), 1247-1277; doi:10.3390/molecules17021247

Chiroptical Switches: Applications in Sensing and Catalysis

1,* , 2 and 1
1 Department of Chemistry and Physical Sciences, Pace University, 1 Pace Plaza, New York, NY 10038, USA 2 Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003, USA
* Author to whom correspondence should be addressed.
Received: 28 December 2011 / Revised: 18 January 2012 / Accepted: 20 January 2012 / Published: 31 January 2012
(This article belongs to the Special Issue Chiroptical Techniques)
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Chiroptical switches have found application in the detection of a multitude of different analytes with a high level of sensitivity and in asymmetric catalysis to offer switchable stereoselectivity. A wide range of scaffolds have been employed that respond to metals, small molecules, anions and other analytes. Not only have chiroptical systems been used to detect the presence of analytes, but also other properties such as oxidation state and other physical phenomena that influence helicity and conformation of molecules and materials. Moreover, the tunable responses of many such chiroptical switches enable them to be used in the controlled production of either enantiomer or diastereomer at will in many important organic reactions from a single chiral catalyst through selective use of a low-cost inducer: Co-catalysts (guests), metal ions, counter ions or anions, redox agents or electrochemical potential, solvents, mechanical forces, temperature or electromagnetic radiation.
Keywords: chiroptical switches; molecular recognition; sensor; chiral analyte; achiral analyte; asymmetric catalysis chiroptical switches; molecular recognition; sensor; chiral analyte; achiral analyte; asymmetric catalysis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Dai, Z.; Lee, J.; Zhang, W. Chiroptical Switches: Applications in Sensing and Catalysis. Molecules 2012, 17, 1247-1277.

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