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Molecules 2012, 17(12), 14918-14927; doi:10.3390/molecules171214918
Article

Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery

1,2, 2,†, 2, 2, 2, 2, 2,† and 1,*
Received: 22 October 2012; in revised form: 19 November 2012 / Accepted: 7 December 2012 / Published: 13 December 2012
(This article belongs to the Section Metabolites)
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Abstract: Flowers of Carthamus tinctorius L. are traditionally used in China to treat cerebrovascular and cardiovascular diseases. Hydroxysafflor yellow A (HSYA), the main constituent of Carthamus tinctorius L. flowers, is known for its multiple biological activities. In the present study, HSYA was isolated from Carthamus tinctorius L. flowers by a macroporous resin adsorption chromatography method coupled with a Waters high-throughput auto-purification system and it's vasodilatation effects on pulmonary artery (PA) were explored by an assay of tension study on rat pulmonary artery (PA) rings. Results suggest that HSYA possesses vascular relaxation effects on rat PA by activating the KV channel in pulmonary vascular smooth muscle cells (PVSMCs).
Keywords: HSYA; Carthamus tinctorius L.; pulmonary arteries; vasodilatation HSYA; Carthamus tinctorius L.; pulmonary arteries; vasodilatation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Bai, Y.; Lu, P.; Han, C.; Yu, C.; Chen, M.; He, F.; Yi, D.; Wu, L. Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery. Molecules 2012, 17, 14918-14927.

AMA Style

Bai Y, Lu P, Han C, Yu C, Chen M, He F, Yi D, Wu L. Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery. Molecules. 2012; 17(12):14918-14927.

Chicago/Turabian Style

Bai, Yuhua; Lu, Ping; Han, Chenghua; Yu, Chunyue; Chen, Minggang; He, Fa; Yi, Dan; Wu, Lijun. 2012. "Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery." Molecules 17, no. 12: 14918-14927.


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