Abstract: A series of macrocyclic imides and Schiff-bases have been prepared via the cyclocondensation of pyridine-2,6-dicarbonyl dichloride (1) with L-ornithine methyl ester to give the corresponding macrocyclic bisester 2. Treatment of 2 with hydrazine hydrate gave macrocyclic bisacid hydrazide 3, which was used as starting material. Condensation of bishydrazide 3 with diacid anhydrides or aromatic aldehydes in refluxing acetic acid or ethanol gave the corresponding macrocyclic bisimides 4, 5a,b and macrocyclic bis- hydrazones 6a–j, respectively. The structure assignments of the new compounds were based on chemical and spectroscopic evidence. The antimicrobial screening showed that many of these newly synthesized compounds have good antimicrobial activities, comparable to ampicillin and ketaconazole used as reference drugs.
Keywords: macrocyclic polyamide candidates; amino acids; Schiff’s base; antimicrobial activity
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El-Salam, O.I.A.; Al-Omar, M.A.; Fayed, A.A.; Flefel, E.M.; Amr, A.E.-G. Synthesis of New Macrocyclic Polyamides as Antimicrobial Agent Candidates. Molecules 2012, 17, 14510-14521.
El-Salam OIA, Al-Omar MA, Fayed AA, Flefel EM, Amr AE-G. Synthesis of New Macrocyclic Polyamides as Antimicrobial Agent Candidates. Molecules. 2012; 17(12):14510-14521.
El-Salam, Osama I.A.; Al-Omar, Mohamed A.; Fayed, Ahmed A.; Flefel, Eman M.; Amr, Abd E.-G. 2012. "Synthesis of New Macrocyclic Polyamides as Antimicrobial Agent Candidates." Molecules 17, no. 12: 14510-14521.