Molecules 2012, 17(12), 14146-14158; doi:10.3390/molecules171214146
Article

Ultrasound-Promoted Greener Synthesis of Novel Trifurcate 3-Substituted-chroman-2,4-dione Derivatives and Their Drug-Likeness Evaluation

School of Pharmacy, China Pharmaceutical University, Nanjing 210009, Jiangsu, China
* Author to whom correspondence should be addressed.
Received: 23 October 2012; in revised form: 12 November 2012 / Accepted: 23 November 2012 / Published: 28 November 2012
(This article belongs to the Section Molecular Diversity)
PDF Full-text Download PDF Full-Text [287 KB, Updated Version, uploaded 4 December 2012 15:24 CET]
The original version is still available [285 KB, uploaded 28 November 2012 11:01 CET]
Abstract: An efficient and convenient approach for one-pot synthesis of 3-substituted chroman-2,4-diones via a three-component reaction of aromatic aldehydes, 4-hydroxy- coumarins and diverse pyrazolone derivatives was described. The combinatorial synthesis for this methodology was achieved by applying ultrasound irradiation in the absence of activator while making use of water as green solvent. Additionally, novel chroman-2,4-dione derivatives attached to an edaravone moiety represent an exploitable source of brand new anticancer agents. In comparison with conventional methods, experimental simplicity, good functional group tolerance, excellent yields, short routine, and atom efficiency are prominent features of this sonocatalyzed procedure.
Keywords: chroman-2,4-diones; multicomponent reactions (MCRs); ultrasonic irradiation; green chemistry; coumarin; edaravone

Supplementary Files

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Liang, C.; Jiang, H.; Zhou, Z.; Lei, D.; Xue, Y.; Yao, Q. Ultrasound-Promoted Greener Synthesis of Novel Trifurcate 3-Substituted-chroman-2,4-dione Derivatives and Their Drug-Likeness Evaluation. Molecules 2012, 17, 14146-14158.

AMA Style

Liang C, Jiang H, Zhou Z, Lei D, Xue Y, Yao Q. Ultrasound-Promoted Greener Synthesis of Novel Trifurcate 3-Substituted-chroman-2,4-dione Derivatives and Their Drug-Likeness Evaluation. Molecules. 2012; 17(12):14146-14158.

Chicago/Turabian Style

Liang, Chengyuan; Jiang, Hailong; Zhou, Zhiguang; Lei, Dong; Xue, Yu; Yao, Qizheng. 2012. "Ultrasound-Promoted Greener Synthesis of Novel Trifurcate 3-Substituted-chroman-2,4-dione Derivatives and Their Drug-Likeness Evaluation." Molecules 17, no. 12: 14146-14158.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert