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Molecules 2012, 17(12), 14015-14021; doi:10.3390/molecules171214015

New Furanones from the Plant Endophytic Fungus Pestalotiopsis besseyi

1, 2,3, 3, 4, 5 and 1,*
1 Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China 2 Graduate School of Chinese Academy of Sciences, Beijing 100086, China 3 Institute of Microbiology, Beijing 100086, China 4 Biotechnology Center of Shandong Academy of Sciences, Jinan 250014, Shandong, China 5 College of Life Science, Shaanxi Normal University, Xi'an 710062, Shaanxi, China
* Author to whom correspondence should be addressed.
Received: 24 October 2012 / Revised: 22 November 2012 / Accepted: 23 November 2012 / Published: 27 November 2012
(This article belongs to the Section Natural Products)
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Pestalafuranones A–E (compounds 15), five new 2(5H)-furanones, have been isolated from cultures of an isolate of Pestalotiopsis besseyi. The structures of these compounds were elucidated mainly by analysis of their NMR spectroscopic data and HRESIMS experiments. Pestalafuranones A–C (compounds 13) displayed weak inhibitory effects against HIV-1 replication in C8166 cells, whereas pestalafuranones D (4) and E (5) showed moderate antifungal activity against the plant pathogens Verticillium dahiae and Alternaria longipes.
Keywords: pestalafuranones A–E; endophytes; Pestalotiopsis besseyi; bioactivity pestalafuranones A–E; endophytes; Pestalotiopsis besseyi; bioactivity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Liu, H.; Liu, S.; Guo, L.; Zhang, Y.; Cui, L.; Ding, G. New Furanones from the Plant Endophytic Fungus Pestalotiopsis besseyi. Molecules 2012, 17, 14015-14021.

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