Molecules 2012, 17(11), 13266-13274; doi:10.3390/molecules171113266
Communication

Radioiodination of Aryl-Alkyl Cyclic Sulfates

1 Massachusetts General Hospital, Harvard Medical School and Shriners Hospital for Children, Shriners Hospital for Children—Boston, Room 439, 51 Blossom St., Boston, MA 02114, USA 2 Massachusetts General Hospital, Harvard Medical School and Shriners Hospitals for Children, Shriners Hospital for Children—Boston, Room 224, 51 Blossom St., Boston, MA 02114, USA
* Authors to whom correspondence should be addressed.
Received: 7 September 2012; in revised form: 24 September 2012 / Accepted: 23 October 2012 / Published: 7 November 2012
(This article belongs to the Special Issue Organic Iodine Chemistry 2012)
PDF Full-text Download PDF Full-Text [217 KB, uploaded 7 November 2012 11:09 CET]
Abstract: Among the currently available positron emitters suitable for Positron Emission Tomography (PET), 124I has the longest physical half-life (4.2 days). The long half-life and well-investigated behavior of iodine in vivo makes 124I very attractive for pharmacological studies. In this communication, we describe a simple yet effective method for the synthesis of novel 124I labeled compounds intended for PET imaging of arylsulfatase activity in vivo. Arylsulfatases have important biological functions, and genetic deficiencies of such functions require pharmacological replacement, the efficacy of which must be properly and non-invasively evaluated. These enzymes, even though their natural substrates are mostly of aliphatic nature, hydrolyze phenolic sulfates to phenol and sulfuric acid. The availability of [124I]iodinated substrates is expected to provide a PET-based method for measuring their activity in vivo. The currently available methods of synthesis of iodinated arylsulfates usually require either introducing of a protected sulfate ester early in the synthesis or introduction of sulfate group at the end of synthesis in a separate step. The described method gives the desired product in one step from an aryl-alkyl cyclic sulfate. When treated with iodide, the source cyclic sulfate opens with substitution of iodide at the alkyl center and gives the desired arylsulfate monoester.
Keywords: iodine; cyclic sulfate; Positron Emission Tomography; 124I; enzyme substrate

Supplementary Files

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Mushti, C.; Papisov, M.I. Radioiodination of Aryl-Alkyl Cyclic Sulfates. Molecules 2012, 17, 13266-13274.

AMA Style

Mushti C, Papisov MI. Radioiodination of Aryl-Alkyl Cyclic Sulfates. Molecules. 2012; 17(11):13266-13274.

Chicago/Turabian Style

Mushti, Chandra; Papisov, Mikhail I. 2012. "Radioiodination of Aryl-Alkyl Cyclic Sulfates." Molecules 17, no. 11: 13266-13274.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert