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Secondary Metabolites from Two Species of Tolpis and Their Biological Activities
Departamento de Química, Unidad Asociada al CSIC, Universidad de Las Palmas de Gran Canaria, Campus de Tafira, 35017, Las Palmas de Gran Canaria, Spain
Departamento de Bioquímica, Unidad Asociada al CSIC, Universidad de Las Palmas de Gran Canaria, Plaza Dr. Pasteur s/n, 35016, Las Palmas de Gran Canaria, Spain
Fundación Canaria Instituto Canario de Investigación del Cáncer, Torre Agustín Arévalo-7ª Planta (PCTT-ULL) Avda de la Trinidad s/n 38204 San Cristóbal de La Laguna-S/C de Tenerife, Spain
Instituto de Productos Naturales y Agrobiología, Consejo Superior de Investigaciones Científicas (CSIC), Avda. Astrofísico F. Sánchez, 3, 38206 La Laguna, Spain
* Authors to whom correspondence should be addressed.
Received: 27 September 2012; in revised form: 24 October 2012 / Accepted: 26 October 2012 / Published: 1 November 2012
Abstract: Phytochemical research of two Tolpis species, T. proustii and T. lagopoda, led to the isolation of three new compounds: 30-chloro-3β-acetoxy-22α-hydroxyl-20(21)-taraxastene (1), 3β,22α-diacetoxy-30-ethoxy-20(21)-taraxastene (2) and 3β,28-dihydroxy-11α-hydroperoxy-12-ursene (3). The structures of the new compounds were elucidated by means of extensive IR, NMR, and MS data and by comparison of data reported in the literature. The in vitro antioxidant activities of the extracts were assessed by the DPPH and ABTS scavenging methods. The cytotoxicity of several known compounds and its derivatives was also assessed against human myeloid leukemia K-562 and K-562/ADR cell lines.
Keywords: Asteraceae; Tolpis proustii; Tolpis lagopoda; ursane-triterpenes; taraxastane-triterpenes
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MDPI and ACS Style
Triana, J.; López, M.; Pérez, F.J.; Rico, M.; López, A.; Estévez, F.; Marrero, M.T.; Brouard, I.; León, F. Secondary Metabolites from Two Species of Tolpis and Their Biological Activities. Molecules 2012, 17, 12895-12909.
Triana J, López M, Pérez FJ, Rico M, López A, Estévez F, Marrero MT, Brouard I, León F. Secondary Metabolites from Two Species of Tolpis and Their Biological Activities. Molecules. 2012; 17(11):12895-12909.
Triana, Jorge; López, Mariana; Pérez, Francisco J.; Rico, Milagros; López, Aroa; Estévez, Francisco; Marrero, María T.; Brouard, Ignacio; León, Francisco. 2012. "Secondary Metabolites from Two Species of Tolpis and Their Biological Activities." Molecules 17, no. 11: 12895-12909.