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Molecules 2012, 17(11), 12895-12909; doi:10.3390/molecules171112895
Article

Secondary Metabolites from Two Species of Tolpis and Their Biological Activities

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Received: 27 September 2012 / Revised: 24 October 2012 / Accepted: 26 October 2012 / Published: 1 November 2012
(This article belongs to the Section Metabolites)
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Abstract

Phytochemical research of two Tolpis species, T. proustii and T. lagopoda, led to the isolation of three new compounds: 30-chloro-3β-acetoxy-22α-hydroxyl-20(21)-taraxastene (1), 3β,22α-diacetoxy-30-ethoxy-20(21)-taraxastene (2) and 3β,28-dihydroxy-11α-hydroperoxy-12-ursene (3). The structures of the new compounds were elucidated by means of extensive IR, NMR, and MS data and by comparison of data reported in the literature. The in vitro antioxidant activities of the extracts were assessed by the DPPH and ABTS scavenging methods. The cytotoxicity of several known compounds and its derivatives was also assessed against human myeloid leukemia K-562 and K-562/ADR cell lines.
Keywords: Asteraceae; Tolpis proustii; Tolpis lagopoda; ursane-triterpenes; taraxastane-triterpenes Asteraceae; Tolpis proustii; Tolpis lagopoda; ursane-triterpenes; taraxastane-triterpenes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Triana, J.; López, M.; Pérez, F.J.; Rico, M.; López, A.; Estévez, F.; Marrero, M.T.; Brouard, I.; León, F. Secondary Metabolites from Two Species of Tolpis and Their Biological Activities. Molecules 2012, 17, 12895-12909.

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