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Antioxidant, Lipoxygenase and Histone Deacetylase Inhibitory Activities of Acridocarbus orientalis From Al Ain and Oman
Department of Biology, Faculty of Science, U.A.E. University, Al-Ain, P.O. Box 17551, UAE
National Organization of Drug Control and Research, 6 Abu Hazem St., Giza, 12613, Egypt
* Author to whom correspondence should be addressed.
Received: 5 July 2012; in revised form: 3 September 2012 / Accepted: 20 September 2012 / Published: 24 October 2012
Abstract: Acridocarpus orientalis (AO) is a traditional medicinal plant used for treatment of inflammatory diseases that may have potential in cancer treatment. In the present study, the aqueous ethanolic crude extract of Acridocarpus aerial parts obtained from Al Ain and Oman were evaluated for their antioxidant capability, polyphenolic content, anti-lipoxygenase and anti-histone deacetylase (HDAC) properties. The total antioxidant capacity was estimated by the FRAP, DPPH, ABTS and b-carotene bleaching assays. Acridocarpus-Al Ain exhibited the highest polyphenolic content (184.24 mg gallic acid/g) and the best antioxidant activity (1.1, 1.04, 1.14 mmol ascorbic acid equivalent/g in the FRAP, ABTS and DPPH assays, respectively). Additionally, the same extract showed significant anti-inflammatory properties via lipoxygenase (LOX) inhibitory activity (IC50 = 50.58 µg/mL). Acridocarpus-Al Ain also showed the strongest histone deacetylase (HDACs) inhibitory activity (IC50 = 93.28 µg/mL). The results reported here suggest that there was a significant influence of location and the plant may be considered a good source of compounds with antioxidant, anti-LOX and HDAC properties for therapeutic, nutraceutical and functional food applications.
Keywords: Acridocarpus orientalis; total phenol; antioxidant; anti-lipoxygenase; anti-histone deacetylase activity
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MDPI and ACS Style
Ksiksi, T.; Hamza, A.A. Antioxidant, Lipoxygenase and Histone Deacetylase Inhibitory Activities of Acridocarbus orientalis From Al Ain and Oman. Molecules 2012, 17, 12521-12532.
Ksiksi T, Hamza AA. Antioxidant, Lipoxygenase and Histone Deacetylase Inhibitory Activities of Acridocarbus orientalis From Al Ain and Oman. Molecules. 2012; 17(11):12521-12532.
Ksiksi, Taoufik; Hamza, Alaaeldin A. 2012. "Antioxidant, Lipoxygenase and Histone Deacetylase Inhibitory Activities of Acridocarbus orientalis From Al Ain and Oman." Molecules 17, no. 11: 12521-12532.