Next Article in Journal
Previous Article in Journal
Molecules 2012, 17(10), 12460-12468; doi:10.3390/molecules171012460
Article

A Sub-Pathway Based Method to Identify Candidate Agents for Ankylosing Spondylitis

, , , , , ,  and *
Received: 26 June 2012; in revised form: 25 September 2012 / Accepted: 26 September 2012 / Published: 22 October 2012
View Full-Text   |   Download PDF [219 KB, uploaded 18 June 2014]   |   Browse Figure
Abstract: The need for new therapeutics for Ankylosing Spondylitis (AS) is highlighted by the general lack of efficacy for most agents currently available for this disease. Many recent studies have detailed molecular pathways in AS, and several molecule-targeting agents are undergoing evaluation. We aimed to explore the mechanism of AS and identify biologically active small molecules capable of targeting the sub-pathways which were disregulated in the development of AS. By using the GSE25101 microarray data accessible from the Gene Expression Omnibus database, we first identified the differentially expressed genes (DEGs) between AS samples and healthy controls, followed by the sub-pathway enrichment analysis of the DEGs. In addition, we propose the use of an approach based on targeting sub-pathways to identify potential agents for AS. A total of 3,280 genes were identified as being significantly different between patients and controls with p-values < 0.1. Our study showed that neurotrophic signaling pathway and some immune-associated pathways may be involved in the development of AS. Besides, our bioinformatics analysis revealed a total of 15 small molecules which may play a role in perturbing the development of AS. Our study proposes the use of an approach based on targeting sub-pathways to identify potential agents for AS. Candidate agents identified by our approach may provide the groundwork for a combination therapy approach for AS.
Keywords: Ankylosing Spondylitis; bioinformatics; connectivity map; drug discovery Ankylosing Spondylitis; bioinformatics; connectivity map; drug discovery
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Chen, K.; Zhao, Y.; Chen, Y.; Wang, C.; Chen, Z.; Bai, Y.; Zhu, X.; Li, M. A Sub-Pathway Based Method to Identify Candidate Agents for Ankylosing Spondylitis. Molecules 2012, 17, 12460-12468.

AMA Style

Chen K, Zhao Y, Chen Y, Wang C, Chen Z, Bai Y, Zhu X, Li M. A Sub-Pathway Based Method to Identify Candidate Agents for Ankylosing Spondylitis. Molecules. 2012; 17(10):12460-12468.

Chicago/Turabian Style

Chen, Kai; Zhao, Yingchuan; Chen, Yu; Wang, Chuanfeng; Chen, Ziqiang; Bai, Yushu; Zhu, Xiaodong; Li, Ming. 2012. "A Sub-Pathway Based Method to Identify Candidate Agents for Ankylosing Spondylitis." Molecules 17, no. 10: 12460-12468.



Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert