Molecules 2012, 17(10), 12151-12162; doi:10.3390/molecules171012151
Article

Side-chain Modifications of Highly Functionalized 3(2H)-Furanones

Viviani Nardini* email, Shirley Muniz Machado Rodrigues, Maurício Gomes Constantino and Gil Valdo José da Silva
Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Avenida dos Bandeirantes, 3900, 14040-901 Ribeirão Preto, SP, Brazil
* Author to whom correspondence should be addressed.
Received: 29 August 2012; in revised form: 14 September 2012 / Accepted: 7 October 2012 / Published: 16 October 2012
(This article belongs to the Section Organic Synthesis)
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Abstract: A series of 3(2H)-furanones, based on side-chain modifications of a parent 3(2H)-furanone, was synthesized in good yield. The parent compound was prepared by hydrogenolysis, and subsequent acid hydrolysis, of isoxazole derivatives. The isoxazole was prepared by a [3+2] 1,3-dipolar cycloaddition reaction between 3-butyn-2-ol and nitrile oxide.
Keywords: 3(2H)-furanone; isoxazole; natural products; side-chain modifications

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MDPI and ACS Style

Nardini, V.; Rodrigues, S.M.M.; Constantino, M.G.; Silva, G.V.J. Side-chain Modifications of Highly Functionalized 3(2H)-Furanones. Molecules 2012, 17, 12151-12162.

AMA Style

Nardini V, Rodrigues SMM, Constantino MG, Silva GVJ. Side-chain Modifications of Highly Functionalized 3(2H)-Furanones. Molecules. 2012; 17(10):12151-12162.

Chicago/Turabian Style

Nardini, Viviani; Rodrigues, Shirley M.M.; Constantino, Maurício G.; Silva, Gil V.J. 2012. "Side-chain Modifications of Highly Functionalized 3(2H)-Furanones." Molecules 17, no. 10: 12151-12162.

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