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Molecules 2012, 17(10), 12151-12162; doi:10.3390/molecules171012151

Side-chain Modifications of Highly Functionalized 3(2H)-Furanones

Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Avenida dos Bandeirantes, 3900, 14040-901 Ribeirão Preto, SP, Brazil
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Received: 29 August 2012 / Revised: 14 September 2012 / Accepted: 7 October 2012 / Published: 16 October 2012
(This article belongs to the Section Organic Synthesis)
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Abstract

A series of 3(2H)-furanones, based on side-chain modifications of a parent 3(2H)-furanone, was synthesized in good yield. The parent compound was prepared by hydrogenolysis, and subsequent acid hydrolysis, of isoxazole derivatives. The isoxazole was prepared by a [3+2] 1,3-dipolar cycloaddition reaction between 3-butyn-2-ol and nitrile oxide.
Keywords: 3(2H)-furanone; isoxazole; natural products; side-chain modifications 3(2H)-furanone; isoxazole; natural products; side-chain modifications
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Nardini, V.; Rodrigues, S.M.M.; Constantino, M.G.; Silva, G.V.J. Side-chain Modifications of Highly Functionalized 3(2H)-Furanones. Molecules 2012, 17, 12151-12162.

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