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Molecules 2012, 17(10), 12151-12162; doi:10.3390/molecules171012151
Article

Side-chain Modifications of Highly Functionalized 3(2H)-Furanones

* , ,  and
Received: 29 August 2012; in revised form: 14 September 2012 / Accepted: 7 October 2012 / Published: 16 October 2012
(This article belongs to the Section Organic Synthesis)
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Abstract: A series of 3(2H)-furanones, based on side-chain modifications of a parent 3(2H)-furanone, was synthesized in good yield. The parent compound was prepared by hydrogenolysis, and subsequent acid hydrolysis, of isoxazole derivatives. The isoxazole was prepared by a [3+2] 1,3-dipolar cycloaddition reaction between 3-butyn-2-ol and nitrile oxide.
Keywords: 3(2H)-furanone; isoxazole; natural products; side-chain modifications 3(2H)-furanone; isoxazole; natural products; side-chain modifications
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Nardini, V.; Rodrigues, S.M.M.; Constantino, M.G.; Silva, G.V.J. Side-chain Modifications of Highly Functionalized 3(2H)-Furanones. Molecules 2012, 17, 12151-12162.

AMA Style

Nardini V, Rodrigues SMM, Constantino MG, Silva GVJ. Side-chain Modifications of Highly Functionalized 3(2H)-Furanones. Molecules. 2012; 17(10):12151-12162.

Chicago/Turabian Style

Nardini, Viviani; Rodrigues, Shirley M.M.; Constantino, Maurício G.; Silva, Gil V.J. 2012. "Side-chain Modifications of Highly Functionalized 3(2H)-Furanones." Molecules 17, no. 10: 12151-12162.



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