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Molecules 2012, 17(10), 11554-11569; doi:10.3390/molecules171011554
Article

Design and Synthesis of an 18F-Labeled Version of Phenylethyl Orvinol ([18F]FE-PEO) for PET-Imaging of Opioid Receptors

1
 and
2,3,*
1 ABX Advanced Biochemical Compounds Biomedizinische Forschungsreagenzien GmbH, Heinrich-Glaeser-Strasse 10-14, D-01454 Radeberg, Germany 2 Oslo PET-Centre, Norsk Medisinsk Syklotronsenter AS, N-0027 Oslo, Norway 3 Institute of Basic Medical Sciences, Group of Pharmaceutical Radiochemistry, University of Oslo, Postboks 1110 Blindern, N-0317 Oslo, Norway
* Author to whom correspondence should be addressed.
Received: 13 July 2012 / Revised: 10 September 2012 / Accepted: 11 September 2012 / Published: 28 September 2012
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Abstract

The semisynthetic oripavine derivative phenethyl orvinol (PEO), a full agonist at opioid receptors (OR), is an attractive structural motif for developing 18F-labeled PET tracers with a high degree of sensitivity for competition between endogenous and exogenous OR-ligands. The target cold reference compound 6-O-(2-fluoroethyl)-6-O-desmethylphenylethyl orvinol (FE-PEO) was obtained via two separate reaction routes. A three-step synthesis was developed for the preparation of a tosyloxyethyl precursor (TE-TDPEO), the key precursor for a direct, nucleophilic radiofluorination to yield [18F]FE-PEO. The developed radiosynthesis provides the target compound in relevantly high yield and purity, and is adaptable to routine production.
Keywords: opioid receptors; PET; agonist; 18F-fluorination; automated radiosynthesis opioid receptors; PET; agonist; 18F-fluorination; automated radiosynthesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Marton, J.; Henriksen, G. Design and Synthesis of an 18F-Labeled Version of Phenylethyl Orvinol ([18F]FE-PEO) for PET-Imaging of Opioid Receptors. Molecules 2012, 17, 11554-11569.

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