Molecules 2011, 16(6), 5130-5141; doi:10.3390/molecules16065130
Article

Synthesis and Cytotoxic Evaluation of Novel N-Methyl-4-phenoxypicolinamide Derivatives

Wei Li, Xin Zhai, Lu Ding, Limin Sun, Xiaomei Chen, Ping Gong* email and Tiemin Sun* email
Key Laboratary of Original New Drugs Design and Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China
* Authors to whom correspondence should be addressed.
Received: 1 June 2011; in revised form: 9 June 2011 / Accepted: 10 June 2011 / Published: 20 June 2011
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Abstract: A series of N-methyl-4-phenoxypicolinamide derivatives were synthesized and evaluated in vitro for their cytotoxic activity against A549, H460 and HT29 cell lines. Pharmacological data indicated that some of the target compounds possessed marked antiproliferative activity, superior to that of the reference drug sorafenib. As the most promising compound, 8e exhibited potent cytotoxicity with the IC50 value of 3.6, 1.7 and 3.0 μM against A549, H460 and HT-29 cell lines, respectively.
Keywords: N-methyl-4-phenoxypicolimamide derivatives; synthesis; cytotoxic activity

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MDPI and ACS Style

Li, W.; Zhai, X.; Ding, L.; Sun, L.; Chen, X.; Gong, P.; Sun, T. Synthesis and Cytotoxic Evaluation of Novel N-Methyl-4-phenoxypicolinamide Derivatives. Molecules 2011, 16, 5130-5141.

AMA Style

Li W, Zhai X, Ding L, Sun L, Chen X, Gong P, Sun T. Synthesis and Cytotoxic Evaluation of Novel N-Methyl-4-phenoxypicolinamide Derivatives. Molecules. 2011; 16(6):5130-5141.

Chicago/Turabian Style

Li, Wei; Zhai, Xin; Ding, Lu; Sun, Limin; Chen, Xiaomei; Gong, Ping; Sun, Tiemin. 2011. "Synthesis and Cytotoxic Evaluation of Novel N-Methyl-4-phenoxypicolinamide Derivatives." Molecules 16, no. 6: 5130-5141.

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