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Molecules 2011, 16(6), 5130-5141; doi:10.3390/molecules16065130

Synthesis and Cytotoxic Evaluation of Novel N-Methyl-4-phenoxypicolinamide Derivatives

, , , , , *  and *
Key Laboratary of Original New Drugs Design and Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, China
* Authors to whom correspondence should be addressed.
Received: 1 June 2011 / Revised: 9 June 2011 / Accepted: 10 June 2011 / Published: 20 June 2011
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A series of N-methyl-4-phenoxypicolinamide derivatives were synthesized and evaluated in vitro for their cytotoxic activity against A549, H460 and HT29 cell lines. Pharmacological data indicated that some of the target compounds possessed marked antiproliferative activity, superior to that of the reference drug sorafenib. As the most promising compound, 8e exhibited potent cytotoxicity with the IC50 value of 3.6, 1.7 and 3.0 μM against A549, H460 and HT-29 cell lines, respectively.
Keywords: N-methyl-4-phenoxypicolimamide derivatives; synthesis; cytotoxic activity N-methyl-4-phenoxypicolimamide derivatives; synthesis; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Li, W.; Zhai, X.; Ding, L.; Sun, L.; Chen, X.; Gong, P.; Sun, T. Synthesis and Cytotoxic Evaluation of Novel N-Methyl-4-phenoxypicolinamide Derivatives. Molecules 2011, 16, 5130-5141.

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