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Molecules 2011, 16(6), 4642-4651; doi:10.3390/molecules16064642

Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba

Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China
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Received: 15 April 2011 / Revised: 26 May 2011 / Accepted: 27 May 2011 / Published: 3 June 2011
(This article belongs to the Section Natural Products)
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Abstract

The ethyl acetate soluble fraction from the roots of Sanguisorba tenuifolia was found to have a hypoglucemic effect in alloxan-induced diabetic rats. Two new triterpenoids, identified as 2-oxo-3β,19α-dihydroxyolean-12-en-28-oic acid β-D-gluco-pyranosyl ester (1) and 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid β-D-glucopyranosyl ester (4) were isolated from this fraction, along with thirteen known triterpenoids. Their structures were elucidated by chemical and spectroscopic methods. All these compounds demonstrated inhibitory activities against α-glucosidase with IC50 values in the 0.62-3.62 mM range.
Keywords: Sanguisorba tenuifolia var. Alba; triterpenoids; α-glucosidase inhibitory activity; diabetes mellitus Sanguisorba tenuifolia var. Alba; triterpenoids; α-glucosidase inhibitory activity; diabetes mellitus
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Kuang, H.-X.; Li, H.-W.; Wang, Q.-H.; Yang, B.-Y.; Wang, Z.-B.; Xia, Y.-G. Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba. Molecules 2011, 16, 4642-4651.

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