Abstract: The ethyl acetate soluble fraction from the roots of Sanguisorba tenuifolia was found to have a hypoglucemic effect in alloxan-induced diabetic rats. Two new triterpenoids, identified as 2-oxo-3β,19α-dihydroxyolean-12-en-28-oic acid β-D-gluco-pyranosyl ester (1) and 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid β-D-glucopyranosyl ester (4) were isolated from this fraction, along with thirteen known triterpenoids. Their structures were elucidated by chemical and spectroscopic methods. All these compounds demonstrated inhibitory activities against α-glucosidase with IC50 values in the 0.62-3.62 mM range.
Keywords: Sanguisorba tenuifolia var. Alba; triterpenoids; α-glucosidase inhibitory activity; diabetes mellitus
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Kuang, H.-X.; Li, H.-W.; Wang, Q.-H.; Yang, B.-Y.; Wang, Z.-B.; Xia, Y.-G. Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba. Molecules 2011, 16, 4642-4651.
Kuang H-X, Li H-W, Wang Q-H, Yang B-Y, Wang Z-B, Xia Y-G. Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba. Molecules. 2011; 16(6):4642-4651.
Kuang, Hai-Xue; Li, Hong-Wei; Wang, Qiu-Hong; Yang, Bing-You; Wang, Zhi-Bin; Xia, Yong-Gang. 2011. "Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba." Molecules 16, no. 6: 4642-4651.