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Molecules 2011, 16(6), 4642-4651; doi:10.3390/molecules16064642
Article

Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba

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Received: 15 April 2011 / Revised: 26 May 2011 / Accepted: 27 May 2011 / Published: 3 June 2011
(This article belongs to the Section Metabolites)
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Abstract

The ethyl acetate soluble fraction from the roots of Sanguisorba tenuifolia was found to have a hypoglucemic effect in alloxan-induced diabetic rats. Two new triterpenoids, identified as 2-oxo-3β,19α-dihydroxyolean-12-en-28-oic acid β-D-gluco-pyranosyl ester (1) and 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid β-D-glucopyranosyl ester (4) were isolated from this fraction, along with thirteen known triterpenoids. Their structures were elucidated by chemical and spectroscopic methods. All these compounds demonstrated inhibitory activities against α-glucosidase with IC50 values in the 0.62-3.62 mM range.
Keywords: Sanguisorba tenuifolia var. Alba; triterpenoids; α-glucosidase inhibitory activity; diabetes mellitus Sanguisorba tenuifolia var. Alba; triterpenoids; α-glucosidase inhibitory activity; diabetes mellitus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kuang, H.-X.; Li, H.-W.; Wang, Q.-H.; Yang, B.-Y.; Wang, Z.-B.; Xia, Y.-G. Triterpenoids from the Roots of Sanguisorba tenuifolia var. Alba. Molecules 2011, 16, 4642-4651.

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