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Molecules 2011, 16(5), 4165-4171; doi:10.3390/molecules16054165
Communication

A Regioselective Synthesis of E-Guggulsterone

1
, 2,3,*  and 2,3,*
Received: 18 April 2011; in revised form: 17 May 2011 / Accepted: 18 May 2011 / Published: 20 May 2011
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Abstract: We have successfully prepared E-guggulsterone from 16,17-epoxy-pregnenolone in 84% yield over two steps via a hydrazine reduction and Oppenhauer oxidation. Additionally, isomerization was induced by heat, light (hn) and acid catalysis to convert E- guggulsterone into the corresponding Z isomer.
Keywords: guggulsterone; inflammatory bowel diseases; regioselective synthesis; oppenhauer oxidation guggulsterone; inflammatory bowel diseases; regioselective synthesis; oppenhauer oxidation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ham, J.; Chin, J.; Kang, H. A Regioselective Synthesis of E-Guggulsterone. Molecules 2011, 16, 4165-4171.

AMA Style

Ham J, Chin J, Kang H. A Regioselective Synthesis of E-Guggulsterone. Molecules. 2011; 16(5):4165-4171.

Chicago/Turabian Style

Ham, Jungyeob; Chin, Jungwook; Kang, Heonjoong. 2011. "A Regioselective Synthesis of E-Guggulsterone." Molecules 16, no. 5: 4165-4171.



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