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Molecules 2011, 16(5), 4059-4069; doi:10.3390/molecules16054059
Article

Synthesis of Ginkgolic Acid Analogues and Evaluation of Their Molluscicidal Activity

1, 1, 2, 2, 1, 3, 3, 2,*  and 1,*
1 School of Pharmacy, Fudan University, Shanghai 201203, China 2 Shanghai Medical College, Fudan University, Shanghai 200032, China 3 School of Public Health, Fudan University, Shanghai 200032, China
* Authors to whom correspondence should be addressed.
Received: 16 March 2011 / Revised: 23 April 2011 / Accepted: 9 May 2011 / Published: 17 May 2011
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Abstract

Based on the molluscicidal activity of ginkgolic acids (GAs) isolated from Ginkgo biloba L, a series of Z/E isomers of GA analogues were prepared and evaluated for their molluscicidal activities against the host snail Oncomelania hupensis. The results and analysis of the structure-activity relationship revealed that the E-isomers showed better molluscicidal activities than their Z-isomers. Molluscicidal activities decreased with the shortening of the alkenyl chain lengths.
Keywords: ginkgolic acid analogues; synthesis; molluscicidal activity; snail; schistosomiasis ginkgolic acid analogues; synthesis; molluscicidal activity; snail; schistosomiasis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Zhang, P.; Pan, J.; Duan, W.; Li, X.; Zhang, Y.; Zhou, Y.; Jiang, Q.; Mao, Z.; Yu, P. Synthesis of Ginkgolic Acid Analogues and Evaluation of Their Molluscicidal Activity. Molecules 2011, 16, 4059-4069.

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