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Synthesis of Ginkgolic Acid Analogues and Evaluation of Their Molluscicidal Activity
School of Pharmacy, Fudan University, Shanghai 201203, China
Shanghai Medical College, Fudan University, Shanghai 200032, China
School of Public Health, Fudan University, Shanghai 200032, China
* Authors to whom correspondence should be addressed.
Received: 16 March 2011; in revised form: 23 April 2011 / Accepted: 9 May 2011 / Published: 17 May 2011
Abstract: Based on the molluscicidal activity of ginkgolic acids (GAs) isolated from Ginkgo biloba L, a series of Z/E isomers of GA analogues were prepared and evaluated for their molluscicidal activities against the host snail Oncomelania hupensis. The results and analysis of the structure-activity relationship revealed that the E-isomers showed better molluscicidal activities than their Z-isomers. Molluscicidal activities decreased with the shortening of the alkenyl chain lengths.
Keywords: ginkgolic acid analogues; synthesis; molluscicidal activity; snail; schistosomiasis
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MDPI and ACS Style
Zhang, P.; Pan, J.; Duan, W.; Li, X.; Zhang, Y.; Zhou, Y.; Jiang, Q.; Mao, Z.; Yu, P. Synthesis of Ginkgolic Acid Analogues and Evaluation of Their Molluscicidal Activity. Molecules 2011, 16, 4059-4069.
Zhang P, Pan J, Duan W, Li X, Zhang Y, Zhou Y, Jiang Q, Mao Z, Yu P. Synthesis of Ginkgolic Acid Analogues and Evaluation of Their Molluscicidal Activity. Molecules. 2011; 16(5):4059-4069.
Zhang, Peng; Pan, Jiahu; Duan, Wanxing; Li, Xuedong; Zhang, Yao; Zhou, Yibiao; Jiang, Qingwu; Mao, Zuohua; Yu, Peizhong. 2011. "Synthesis of Ginkgolic Acid Analogues and Evaluation of Their Molluscicidal Activity." Molecules 16, no. 5: 4059-4069.