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Molecules 2011, 16(5), 4059-4069; doi:10.3390/molecules16054059

Synthesis of Ginkgolic Acid Analogues and Evaluation of Their Molluscicidal Activity

1
School of Pharmacy, Fudan University, Shanghai 201203, China
2
Shanghai Medical College, Fudan University, Shanghai 200032, China
3
School of Public Health, Fudan University, Shanghai 200032, China
*
Authors to whom correspondence should be addressed.
Received: 16 March 2011 / Revised: 23 April 2011 / Accepted: 9 May 2011 / Published: 17 May 2011
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Abstract

Based on the molluscicidal activity of ginkgolic acids (GAs) isolated from Ginkgo biloba L, a series of Z/E isomers of GA analogues were prepared and evaluated for their molluscicidal activities against the host snail Oncomelania hupensis. The results and analysis of the structure-activity relationship revealed that the E-isomers showed better molluscicidal activities than their Z-isomers. Molluscicidal activities decreased with the shortening of the alkenyl chain lengths.
Keywords: ginkgolic acid analogues; synthesis; molluscicidal activity; snail; schistosomiasis ginkgolic acid analogues; synthesis; molluscicidal activity; snail; schistosomiasis
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MDPI and ACS Style

Zhang, P.; Pan, J.; Duan, W.; Li, X.; Zhang, Y.; Zhou, Y.; Jiang, Q.; Mao, Z.; Yu, P. Synthesis of Ginkgolic Acid Analogues and Evaluation of Their Molluscicidal Activity. Molecules 2011, 16, 4059-4069.

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