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Molecules 2011, 16(5), 4059-4069; doi:10.3390/molecules16054059
Article

Synthesis of Ginkgolic Acid Analogues and Evaluation of Their Molluscicidal Activity

1, 1, 2, 2, 1, 3, 3, 2,*  and 1,*
1 School of Pharmacy, Fudan University, Shanghai 201203, China 2 Shanghai Medical College, Fudan University, Shanghai 200032, China 3 School of Public Health, Fudan University, Shanghai 200032, China
* Authors to whom correspondence should be addressed.
Received: 16 March 2011 / Revised: 23 April 2011 / Accepted: 9 May 2011 / Published: 17 May 2011
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Abstract

Based on the molluscicidal activity of ginkgolic acids (GAs) isolated from Ginkgo biloba L, a series of Z/E isomers of GA analogues were prepared and evaluated for their molluscicidal activities against the host snail Oncomelania hupensis. The results and analysis of the structure-activity relationship revealed that the E-isomers showed better molluscicidal activities than their Z-isomers. Molluscicidal activities decreased with the shortening of the alkenyl chain lengths.
Keywords: ginkgolic acid analogues; synthesis; molluscicidal activity; snail; schistosomiasis ginkgolic acid analogues; synthesis; molluscicidal activity; snail; schistosomiasis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhang, P.; Pan, J.; Duan, W.; Li, X.; Zhang, Y.; Zhou, Y.; Jiang, Q.; Mao, Z.; Yu, P. Synthesis of Ginkgolic Acid Analogues and Evaluation of Their Molluscicidal Activity. Molecules 2011, 16, 4059-4069.

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