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Molecules 2011, 16(5), 3663-3674; doi:10.3390/molecules16053663

Cytotoxicity and Oral Acute Toxicity Studies of Lantana camara Leaf Extract

Department of Biotechnology, Faculty of Applied Sciences, AIMST University, Jalan Bedong-Semeling, Batu 3 ½, Bukit Air Nasi, Bedong 08100, Kedah, Malaysia
Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800, Pulau Pinang, Malaysia
Author to whom correspondence should be addressed.
Received: 14 March 2011 / Revised: 26 April 2011 / Accepted: 30 April 2011 / Published: 3 May 2011
(This article belongs to the Section Natural Products)
Download PDF [678 KB, 18 June 2014; original version 18 June 2014]


Background: The objective of this study was to investigate the toxicity of Lantana camara methanol extract. Methods: In order to evaluate the toxicity of Lantana camara, the acute toxicity of the methanolic extract on adult mice and cytotoxicity test on Vero cell line were investigated. A fixed large dose of 2 g/kg body weight of L. camara leaf extract was administrated by a single oral gavage according to the OECD procedure. Results: In 2 weeks, L. camara leaf extract showed no obvious acute toxicity. While female mice lost body weight after being treated with single dose of leaf extract in acute toxicity test, male ones lost organ mass, particularly for heart and kidney. The biochemical liver function tests showed significantly elevated TBIL and ALT in the L. camara leaf extract treated female mice group compared with the control group. Cytotoxicity effect of leaf extract of L. camara was estimated through a MTT assay. Cytotoxicity tests on Vero cell line disclosed that leaf extract at concentrations up to 500 µg/mL inhibited the growth of cells 2.5 times less than did Triton 100× 1%. More interestingly, the cytotoxicity initiated to decline at elevated concentrations of this extract. Conclusions: The results of both tests confirm that L. camara shows a pro toxic effect.
Keywords: Lantana camara; cytotoxicity; oral acute toxicity; Vero cell; plant extract Lantana camara; cytotoxicity; oral acute toxicity; Vero cell; plant extract
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Pour, B.M.; Latha, L.Y.; Sasidharan, S. Cytotoxicity and Oral Acute Toxicity Studies of Lantana camara Leaf Extract. Molecules 2011, 16, 3663-3674.

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