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Molecules 2011, 16(4), 3402-3409; doi:10.3390/molecules16043402

N-Cyanomethylnorboldine: A New Aporphine Isolated from Alseodaphne perakensis (Lauraceae)

1 Chemistry Department, Faculty of Science and Mathematic, University of Pendidikan Sultan Idris, Tg. Malim, Perak, Malaysia 2 Centre for Natural Products and Drug Discovery, Block D, Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia 3 Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa, Tokyo 142-8501, Japan 4 Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France
* Author to whom correspondence should be addressed.
Received: 2 March 2011 / Revised: 12 April 2011 / Accepted: 18 April 2011 / Published: 20 April 2011
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A phytochemical study of the bark of Alseodaphne perakensis has yielded three aporphine alkaloids: the new compound N-cyanomethylnorboldine (1), and the two known alkaloids N-methyllaurotetanine (2) and norboldine (3). The isolation was achieved by chromatographic techniques and the structural elucidation was performed via spectral methods, notably 1D- and 2D-NMR, UV, IR, and HRFABMS. The vasorelaxation activity of compound 1 has been studied.
Keywords: Alseodaphne perakensis; Lauraceae; aporphine alkaloid Alseodaphne perakensis; Lauraceae; aporphine alkaloid
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Nafiah, M.A.; Mukhtar, M.R.; Omar, H.; Ahmad, K.; Morita, H.; Litaudon, M.; Awang, K.; Hadi, A.H.A. N-Cyanomethylnorboldine: A New Aporphine Isolated from Alseodaphne perakensis (Lauraceae). Molecules 2011, 16, 3402-3409.

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