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N-Cyanomethylnorboldine: A New Aporphine Isolated from Alseodaphne perakensis (Lauraceae)
Chemistry Department, Faculty of Science and Mathematic, University of Pendidikan Sultan Idris, Tg. Malim, Perak, Malaysia
Centre for Natural Products and Drug Discovery, Block D, Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa, Tokyo 142-8501, Japan
Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France
* Author to whom correspondence should be addressed.
Received: 2 March 2011; in revised form: 12 April 2011 / Accepted: 18 April 2011 / Published: 20 April 2011
Abstract: A phytochemical study of the bark of Alseodaphne perakensis has yielded three aporphine alkaloids: the new compound N-cyanomethylnorboldine (1), and the two known alkaloids N-methyllaurotetanine (2) and norboldine (3). The isolation was achieved by chromatographic techniques and the structural elucidation was performed via spectral methods, notably 1D- and 2D-NMR, UV, IR, and HRFABMS. The vasorelaxation activity of compound 1 has been studied.
Keywords: Alseodaphne perakensis; Lauraceae; aporphine alkaloid
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Nafiah, M.A.; Mukhtar, M.R.; Omar, H.; Ahmad, K.; Morita, H.; Litaudon, M.; Awang, K.; Hadi, A.H.A. N-Cyanomethylnorboldine: A New Aporphine Isolated from Alseodaphne perakensis (Lauraceae). Molecules 2011, 16, 3402-3409.
Nafiah MA, Mukhtar MR, Omar H, Ahmad K, Morita H, Litaudon M, Awang K, Hadi AHA. N-Cyanomethylnorboldine: A New Aporphine Isolated from Alseodaphne perakensis (Lauraceae). Molecules. 2011; 16(4):3402-3409.
Nafiah, Mohd Azlan; Mukhtar, Mat Ropi; Omar, Hanita; Ahmad, Kartini; Morita, Hiroshi; Litaudon, Marc; Awang, Khalijah; Hadi, A. Hamid A. 2011. "N-Cyanomethylnorboldine: A New Aporphine Isolated from Alseodaphne perakensis (Lauraceae)." Molecules 16, no. 4: 3402-3409.