Molecules 2011, 16(4), 3222-3231; doi:10.3390/molecules16043222
Article

Structure Identification of Euphorbia Factor L3 and Its Induction of Apoptosis through the Mitochondrial Pathway

1,3,* email, 2, 4email, 2, 2, 2, 2, 2, 2 and 2,* email
Received: 9 February 2011; in revised form: 4 April 2011 / Accepted: 12 April 2011 / Published: 15 April 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: In this article, we have focused on the structure identification of Euphorbia factor L3 belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed. Its anticancer activity in vitro against lung cancer A549 cells was also investigated and the IC50 values were 34.04 ± 3.99 μM. Furthermore, Euphorbia factor L3 could induce apoptosis in A549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c.
Keywords: euphorbia factor L3; caper euphorbia seed; apoptosis; mitochondrial pathway
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MDPI and ACS Style

Zhang, J.-Y.; Liang, Y.-J.; Chen, H.-B.; Zheng, L.-S.; Mi, Y.-J.; Wang, F.; Zhao, X.-Q.; Wang, X.-K.; Zhang, H.; Fu, L.-W. Structure Identification of Euphorbia Factor L3 and Its Induction of Apoptosis through the Mitochondrial Pathway. Molecules 2011, 16, 3222-3231.

AMA Style

Zhang J-Y, Liang Y-J, Chen H-B, Zheng L-S, Mi Y-J, Wang F, Zhao X-Q, Wang X-K, Zhang H, Fu L-W. Structure Identification of Euphorbia Factor L3 and Its Induction of Apoptosis through the Mitochondrial Pathway. Molecules. 2011; 16(4):3222-3231.

Chicago/Turabian Style

Zhang, Jian-Ye; Liang, Yong-Ju; Chen, Hu-Biao; Zheng, Li-Sheng; Mi, Yan-Jun; Wang, Fang; Zhao, Xiao-Qin; Wang, Xiao-Kun; Zhang, Hui; Fu, Li-Wu. 2011. "Structure Identification of Euphorbia Factor L3 and Its Induction of Apoptosis through the Mitochondrial Pathway." Molecules 16, no. 4: 3222-3231.

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