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Structure Identification of Euphorbia Factor L3 and Its Induction of Apoptosis through the Mitochondrial Pathway
Department of Pharmaceutical Sciences, School of Basic Science, Guangzhou Medical College, Guangzhou 510182, China
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China
Guangzhou Institute of Respiratory Diseases, State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical College, Guangzhou 510120, China
School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
* Authors to whom correspondence should be addressed.
Received: 9 February 2011; in revised form: 4 April 2011 / Accepted: 12 April 2011 / Published: 15 April 2011
Abstract: In this article, we have focused on the structure identification of Euphorbia factor L3 belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed. Its anticancer activity in vitro against lung cancer A549 cells was also investigated and the IC50 values were 34.04 ± 3.99 μM. Furthermore, Euphorbia factor L3 could induce apoptosis in A549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c.
Keywords: euphorbia factor L3; caper euphorbia seed; apoptosis; mitochondrial pathway
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Zhang, J.-Y.; Liang, Y.-J.; Chen, H.-B.; Zheng, L.-S.; Mi, Y.-J.; Wang, F.; Zhao, X.-Q.; Wang, X.-K.; Zhang, H.; Fu, L.-W. Structure Identification of Euphorbia Factor L3 and Its Induction of Apoptosis through the Mitochondrial Pathway. Molecules 2011, 16, 3222-3231.
Zhang J-Y, Liang Y-J, Chen H-B, Zheng L-S, Mi Y-J, Wang F, Zhao X-Q, Wang X-K, Zhang H, Fu L-W. Structure Identification of Euphorbia Factor L3 and Its Induction of Apoptosis through the Mitochondrial Pathway. Molecules. 2011; 16(4):3222-3231.
Zhang, Jian-Ye; Liang, Yong-Ju; Chen, Hu-Biao; Zheng, Li-Sheng; Mi, Yan-Jun; Wang, Fang; Zhao, Xiao-Qin; Wang, Xiao-Kun; Zhang, Hui; Fu, Li-Wu. 2011. "Structure Identification of Euphorbia Factor L3 and Its Induction of Apoptosis through the Mitochondrial Pathway." Molecules 16, no. 4: 3222-3231.