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Molecules 2011, 16(4), 3222-3231; doi:10.3390/molecules16043222
Article

Structure Identification of Euphorbia Factor L3 and Its Induction of Apoptosis through the Mitochondrial Pathway

1,3,* , 2, 4
, 2, 2, 2, 2, 2, 2 and 2,*
1 Department of Pharmaceutical Sciences, School of Basic Science, Guangzhou Medical College, Guangzhou 510182, China 2 State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China 3 Guangzhou Institute of Respiratory Diseases, State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical College, Guangzhou 510120, China 4 School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
* Authors to whom correspondence should be addressed.
Received: 9 February 2011 / Revised: 4 April 2011 / Accepted: 12 April 2011 / Published: 15 April 2011
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Abstract

In this article, we have focused on the structure identification of Euphorbia factor L3 belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed. Its anticancer activity in vitro against lung cancer A549 cells was also investigated and the IC50 values were 34.04 ± 3.99 μM. Furthermore, Euphorbia factor L3 could induce apoptosis in A549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c.
Keywords: euphorbia factor L3; caper euphorbia seed; apoptosis; mitochondrial pathway euphorbia factor L3; caper euphorbia seed; apoptosis; mitochondrial pathway
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Zhang, J.-Y.; Liang, Y.-J.; Chen, H.-B.; Zheng, L.-S.; Mi, Y.-J.; Wang, F.; Zhao, X.-Q.; Wang, X.-K.; Zhang, H.; Fu, L.-W. Structure Identification of Euphorbia Factor L3 and Its Induction of Apoptosis through the Mitochondrial Pathway. Molecules 2011, 16, 3222-3231.

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